Activatable MRI probes for the specific detection of bacteria.

Activatable fluorescent probes have been successfully used as molecular tools for biomedical research in the last decades. Fluorescent probes allow the detection of molecular events, providing an extraordinary platform for protein and cellular research. Nevertheless, most of the fluorescent probes reported are susceptible to interferences from endogenous fluorescence (background signal) and limited tissue penetration is expected.

Surgical procedures for children in the public healthcare sector: a nationwide, facility-based study in Uganda.

Objective: This study investigated the surgical services for children at the highest levels of the public healthcare sector in Uganda. The aim was to determine volumes and types of procedure performed and the patients and the human resource involved.

Design: The study was a facility-based, record review.

Residual cyclegan for robust domain transformation of histopathological tissue slides.

Variation between stains in histopathology is commonplace across different medical centers. This can have a significant effect on the reliability of machine learning algorithms. In this paper, we propose to reduce performance variability by using -consistent generative adversarial (CycleGAN) networks to remove staining variation.

Linking knowledge and attitudes: Determining neurotypical knowledge about and attitudes towards autism.

"Why are neurotypicals so pig-ignorant about autism?" an autistic person wrote on the Curtin Autism Research Group's on-line portal as a response to a call for research questions. Co-produced with an autistic researcher, knowledge about and attitudes towards autism were analysed from 1,054 completed surveys, representing the Australian neurotypical adult population. The majority, 81.

Efficacy and Safety of Evolocumab in Chronic Kidney Disease in the FOURIER Trial.

Background: Data on PCSK9 inhibition in chronic kidney disease (CKD) is limited.

Objectives: The purpose of this study was to compare outcomes with evolocumab and placebo according to kidney function.

Methods: The FOURIER (Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk) trial randomized individuals with clinically evident atherosclerosis and low-density lipoprotein cholesterol (LDL-C) ≥70 mg/dl or non-high-density lipoprotein cholesterol ≥100 mg/dl to evolocumab or placebo.

Rapid and specific detection of Salmonella infections using chemically modified nucleic acid probes.

Salmonella is a leading source of bacterial foodborne illness in humans, causing gastroenteritis outbreaks with bacteraemia occurrences that can lead to clinical complications and death. Eggs, poultry and pig products are considered as the main carriers of the pathogenic Salmonella for humans. To prevent this relevant zoonosis, key changes in food safety regulations were undertaken to improve controls in the food production chain.

Correction: W.C. Mak, et al. Controlled Delivery of Human Cells by Temperature Responsive Microcapsules. J. Funct. Biomater. 2015, 6, 439-453.

Recently, we found a mistake in Figure 4D in our previously published paper[...

Gradient-dependent release of the model drug TRITC-dextran from FITC-labeled BSA hydrogel nanocarriers in the hair follicles of porcine ear skin.

Hair follicle research is currently focused on the development of drug-loaded nanocarriers for the targeting of follicular structures in the treatment of skin and hair follicle-related disorders. In the present study, a dual-label nanocarrier system was implemented in which FITC-labeled BSA hydrogel nanocarriers loaded with the model drug and dye TRITC-dextran were applied topically to porcine ear skin. Follicular penetration and the distribution of both dyes corresponding to the nanocarriers and the model drug in the follicular ducts subsequent to administration to the skin were investigated using confocal laser scanning microscopy.

Acquisition of Conditioning between Methamphetamine and Cues in Healthy Humans.

Environmental stimuli repeatedly paired with drugs of abuse can elicit conditioned responses that are thought to promote future drug seeking. We recently showed that healthy volunteers acquired conditioned responses to auditory and visual stimuli after just two pairings with methamphetamine (MA, 20 mg, oral). This study extended these findings by systematically varying the number of drug-stimuli pairings.

Triggered release of model drug from AuNP-doped BSA nanocarriers in hair follicles using IRA radiation.

Unlabelled: Recent advances in the field of dermatotherapy have resulted in research efforts focusing on the use of particle-based drug delivery systems for the stimuli-responsive release of drugs in the skin and skin appendages, i.e. hair follicles and sebaceous glands.

Controlled Delivery of Human Cells by Temperature Responsive Microcapsules.

Cell therapy is one of the most promising areas within regenerative medicine. However, its full potential is limited by the rapid loss of introduced therapeutic cells before their full effects can be exploited, due in part to anoikis, and in part to the adverse environments often found within the pathologic tissues that the cells have been grafted into. Encapsulation of individual cells has been proposed as a means of increasing cell viability.

NGAL and cystatin C: two possible early markers of diabetic nephropathy in young patients with type 1 diabetes mellitus: one year follow up.

Objective: Diabetic nephropathy constitutes a major long-term complication in patients with type 1 diabetes mellitus (T1D) and its diagnosis is based on microalbuminuria. The aim of this observational follow-up study was to explore the role of neutrophil-gelatinase-associated lipocalin (NGAL) and cystatin C in unravelling early diabetic nephropathy even in patients with normoalbuminuria.

Design: Fifty-six euthyroid patients with T1D, with mean age 13.

Venous thromboembolism in recipients of antipsychotics: incidence, mechanisms and management.

Since chlorpromazine was introduced to the market in the early 1950s, the use of antipsychotic drugs has been associated with venous thromboembolism (VTE) in a number of reports. During the last decade the evidence has been strengthened with large epidemiological studies. Whether all antipsychotics increase the risk for VTE or the risk is confined to certain drugs is still unclear.

Development and validation of a new Arrhythmia-Specific questionnaire in Tachycardia and Arrhythmia (ASTA) with focus on symptom burden.

Background: Arrhythmias can appear with a variety of symptoms, all from vague to pronounced and handicapping symptoms. Therefore, patient-reported outcomes (PROs) concerning symptom burden are important to assess and take into consideration in the care and treatment of patients with arrhythmias. The main purpose was to develop and validate a disease-specific questionnaire evaluating symptom burden in patients with different forms of arrhythmias.

Consequences of controlling background sounds: the effect of experiential avoidance on tinnitus interference.

Objective: Masking by the use of sounds has been one of the most commonly applied means of coping with tinnitus. The ability to control auditory stimulation represents a potentially important process involved in tinnitus masking strategies. Little is, however, known about the consequences of control on tinnitus experience.

Parent's conceptions of intensive group training. The case of cerebral palsy.

Purpose: The aim was to explore what wants and needs intensive group training (IGT) fulfil for parents of children with cerebral palsy (CP) and what problems that may arise due to participation.

Methods: A phenomenograpical approach was used. Semi-structured interviews were conducted to elicit information about what participation means to parents.

Acidic preparations of platelet concentrates release bone morphogenetic protein-2.

Background And Purpose: Growth factors released from platelets have potent effects on fracture and wound healing. The acidic tide of wound healing, i.e.

Prerequisites for carrying out physiotherapy and physical activity - experiences from adults with cerebral palsy.

Purpose: The aim of this study was to get a deeper understanding into how adults with cerebral palsy (CP) experience physiotherapy and physical activity in a perspective from childhood to adulthood; and how personal and environmental factors influence possibilities for physiotherapy and physical activity.

Method: Data was collected through interviews with 22 community-living adults (35 - 68 years) with CP, from five counties in Sweden. The questions were open-ended and the interviews were taped and transcribed to written language.

Receiving a diagnosis of inoperable lung cancer: patients' perspectives of how it affects their life situation and quality of life.

Lung cancer is a disease with many biomedical and psychological symptoms. The diagnosis and treatment of lung cancer induces adverse effects. Having an inoperable lung cancer there are few possibilities of being cured.

Good self-rated health is related to psychosocial resources and a strong cortisol response to acute stress: the LiVicordia study of middle-aged men.

Self-rated health (SRH) is a strong predictor for disease and death. The relations among SRH, psychosocial factors, and cortisol dynamics were tested using pooled data from the LiVicordia study of 50-year-old men in Lithuania (n = 94) and Sweden (n = 89), controlling for effect of residence. SRH was assessed by "How would you assess your own health?" A standardized laboratory stress test included measures of cortisol in serum and saliva.