2 results match your criteria: "Linkou Chang Gung University and Memorial Hospital[Affiliation]"
The susceptibility of single nucleotide polymorphisms located within co-stimulatory pathways to systemic lupus erythematosus.
Front Immunol
February 2024
Division of Rheumatology, Allergy, and Immunology, Linkou Chang Gung University and Memorial Hospital, Taoyuan, Taiwan.
Article Synopsis
- Autoimmune diseases arise from the immune system losing tolerance, complicating treatment due to complex mechanisms involved in T/B cell activation.
- Researchers analyzed gene polymorphisms in co-stimulatory molecules on antigen-presenting cells from 60 systemic lupus erythematosus (SLE) patients and 60 controls.
- Specific genetic variants in the CD80 and PDL1 genes were linked to SLE, suggesting that these polymorphisms may influence gene activity and play a role in the disease's development.
Exploration of the association between the single-nucleotide polymorphism of co-stimulatory system and rheumatoid arthritis.
Front Immunol
July 2023
Division of Rheumatology, Allergy, and Immunology, Linkou Chang Gung University and Memorial Hospital, Taoyuan, Taiwan.
Introduction: The human leukocyte antigen (HLA) has been linked to the majority of autoimmune diseases (ADs). However, non-HLA genes may be risk factors for ADs. A number of genes encoding proteins involved in regulating T-cell and B-cell function have been identified as rheumatoid arthritis (RA) susceptibility genes.
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