1,861 results match your criteria: "Linkou Chang Gung Memorial Hospital[Affiliation]"

Objectives: We investigate if sublingual space invasion (SLI) determined on magnetic resonance imaging confers differences in clinicopathological manifestations and treatment outcomes of oral tongue squamous cell carcinoma (OTSCC).

Study Design: Retrospective cohort study.

Setting: Tertiary Academic Medical Center.

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Background: Surgical smoke generated by energy devices poses health risks to medical staff. During laparoscopic surgery, the smoke aggregating around the camera obstructs the visual field, forcing surgeons to interrupt surgery, and may increase surgical risk. We propose a proximal smoke evacuation method to improve surgical quality by effectively eliminating surgical smoke.

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Exploring Xiaojianzhong decoction's potential in gastric cancer treatment: Integrative insights and experimental validation.

World J Gastrointest Oncol

December 2024

Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, Taichung 404328, Taiwan.

Gastric cancer (GC) remains a formidable global health concern with significant morbidity and mortality rates, despite the fact that numerous advances have been made to improve conventional therapies. Xiaojianzhong decoction (XJZ), a traditional Chinese medicine, has garnered academic attention as a multicomponent, multitarget approach to managing GC. The present editorial explores the potential of XJZ in the treatment of GC through a comprehensive analysis of network pharmacology and experimental validation.

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Non-recovery acute kidney injury and additional risk factors for short-term and long-term hypoglycemia: A multi-institutional cohort study.

J Formos Med Assoc

December 2024

Department of Nephrology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; Kidney Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; Graduate Institute of Clinical Medical Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: Acute kidney injury (AKI) is associated with increased in-hospital and short-term hypoglycemia risk. However, the impact of non-recovery of renal function before discharge on hypoglycemia risk in AKI survivors after discharge have not been well studied. We aim to analyze the association between non-recovery of AKI and hypoglycemia, hyperglycemia crisis risk, to identify additional risk factors for hypoglycemia, and to examine the impact of AKI non-recovery on HbA1c variability.

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Background: Shared decision-making (SDM) is crucial in healthcare to facilitate effective communication between providers and patients, aiding in making optimal medical decisions. Communication skills training (CST) can improve physicians' ability in SDM. However, SDM CST for medical students in Taiwan is scarce, and research comparing online versus in-person CST outcomes is lacking.

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Long-acting injectable antipsychotic use in patients with bipolar disorder: Findings from the REAP-BD study.

Asian J Psychiatr

December 2024

Department of Psychiatry, Taipei City Hospital and Psychiatric Center, Taipei, Taiwan; Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address:

Aims: This study aimed to assess treatment patterns and the effectiveness of long-acting injectable antipsychotics (LAIs) in patients with bipolar disorder (BD) across various Asian countries. The study focused on comparing the choices of LAIs, other psychotropic medications, and their psychotropic drug load to explore real-world usage and evaluate the potential benefits of LAIs in BD treatment across different countries.

Methods: A retrospective cohort study was conducted with BD patients diagnosed according to ICD-10-CM codes F31.

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Introduction: Natural killer (NK) cell activity (NKA) is downregulated in patients with colorectal cancer (CRC), and its dysfunction is possibly associated with increased risk of recurrence. However, its role in prognosis of CRC remains unclear. Prior research has shown that surgical stress can suppress NKA.

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Canine mammary tumor (CMT) is a prevalent and destructive disease often diagnosed at an advanced stage, leading to poor outcomes. Currently, there is a lack of effective biomarkers for early detection and prognostic prediction of CMT. To improve CMT detection, we established a multiplexed immunoassay using a fluorescence bead-based suspension array system to measure serum levels of autoantibodies against four CMT-associated proteins (AGR2, HAPLN1, IGFBP5, and TYMS) in CMT patients.

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Refining adipose-derived stem cell isolation for optimal regenerative therapy.

World J Stem Cells

November 2024

Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, Taichung City 404328, Taiwan.

This article highlights the importance of optimizing the techniques used for isolating stromal vascular fraction cells from adipose tissue. Furthermore, by presenting key findings from the literature, it clarifies the effects of refined techniques on regenerative medicine and advocates for ongoing research and innovation to enhance therapeutic outcomes.

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The benefit of early acupuncture within 7 days for neurological outcomes in ischemic stroke patients after cardiac surgery.

Perioper Med (Lond)

November 2024

Division of Acupuncture and Traumatology, Department of Traditional Chinese Medicine, LinKou Chang Gung Memorial Hospital, No.5, Fuxing St., Guishan Dist., Taoyuan, 333, Taiwan.

Background: Stroke is a critical complication of cardiac surgery that results in increased mortality and morbidity. Limited treatment options are available for patients with severe neurological deficits, such as impaired consciousness. Acupuncture is a well-known integrative management method for stroke patients.

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Genomic Surveillance of SARS-CoV-2 in Taiwan: A Perspective on Evolutionary Data Interpretation and Sequencing Issues.

Biomed J

November 2024

Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Computer Science and Information Engineering, College of Engineering, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Article Synopsis
  • - The review explores Taiwan's use of genomic surveillance and next-generation sequencing to monitor SARS-CoV-2, highlighting its role in managing COVID-19 spread.
  • - It discusses the challenges of genomic data, like quality concerns and the need for interdisciplinary approaches, especially in the context of Taiwan's high population density and international travel.
  • - The article emphasizes the importance of genomic data in shaping public health policies, such as travel restrictions and vaccine distribution, while urging future research to focus on integrating evolutionary data science methodologies for better analysis.
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Cardiotoxicity concerns in total joint arthroplasty.

World J Orthop

November 2024

Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, Taichung City 404328, Taiwan.

This editorial examines the cardiotoxic effects of elevated metal concentrations in patients who received total joint arthroplasty, as detailed in the study of Brennan The study findings reveal that elevated cobalt and titanium levels may affect the cardiac structure and function, providing crucial insights for clinical practice and research. This editorial suggests that the close monitoring of metal ion levels in patients undergoing arthroplasty is necessary to reduce cardiovascular risk.

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Article Synopsis
  • A study tested the effectiveness of inhaled colistin in treating ventilator-associated pneumonia caused by resistant bacteria, using two types of nebulizers: a vibrating mesh nebulizer (VMN) and a jet nebulizer (JN).
  • Patients receiving intravenous (IV) colistin inhalation were randomly assigned to either nebulizer type and compared to a control group receiving IV only over a period of 7 to 10 days, with a focus on clinical improvement.
  • While VMN delivered a higher dose of colistin in lab tests, both nebulizers showed similar clinical outcomes in patients, showing significant benefits over the IV-only group.
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Background: Co-stimulatory and co-inhibitory molecules are critical to T cell responses and involved in the pathogenesis of systemic lupus erythematosus (SLE). This study aimed to comprehensively analyze the surface expression of these molecules in various phenotypic immune cells, comparing the differences between various levels of the severity in SLE and control groups.

Methods: Peripheral blood mononuclear cells (PBMCs) were isolated using Ficoll-Paque from blood samples of severe SLE patients (treatment with immunosuppressants), mild SLE patients (excluding those with persistent proteinuria or thrombocytopenia), and healthy controls ( = 10 each).

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Background: Robot-assisted rehabilitation is considered beneficial for functional recovery in patients with stroke, but the therapeutic effect remains inconclusive. The present study investigated the therapeutic effects of gait training assisted by a user-initiated powered exoskeletal robot (UIPER) in patients in the early stage after stroke. We also characterized patients' improvement by analyzing chronological changes in clinical measurements together with gait parameters obtained from internal sensors in the exoskeletal robot.

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Factors associated with functional ability in patients with esophageal cancer undergoing chemoradiotherapy: a prospective longitudinal study.

Support Care Cancer

November 2024

Department of Radiation Oncology, and Proton and Radiation Therapy Center, Chang Gung Medical Foundation, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, Republic of China.

Article Synopsis
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Background The growing population of male adolescent and young adult (AYA, 15-40 years old) cancer survivors has heightened interest in their reproductive health. However, studies have reported conflicting findings on the potential risks of cancer and its treatments on birth and obstetric outcomes. Methods We utilized encrypted identification numbers for both fathers and mothers to link three nationwide Taiwan datasets from 2004 to 2019, identifying 3,785 births with a paternal history of AYA cancer.

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Targeting neuronal PAS domain protein 2 and KN motif/ankyrin repeat domains 1: Advances in type 2 diabetes therapy.

World J Diabetes

November 2024

Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, Taichung 404328, Taiwan.

This editorial summarizes the latest literature on the roles of neuronal PAS domain protein 2 and KN motif/ankyrin repeat domain 1 in type 2 diabetes (T2D). We highlight their involvement in β-cell dysfunction, explore their potential as therapeutic targets, and discuss the implications for new treatment strategies. We offer valuable insights into relevant gene regulation and cellular mechanisms relevant for the targeted management of T2D.

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Stem cell exosomes: New hope for recovery from diabetic brain hemorrhage.

World J Diabetes

November 2024

Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, Taichung 404328, Taiwan.

Recent advancements in stem cell-derived exosome therapy for diabetic brain hemorrhage are discussed in this editorial, which highlights this therapy's potential for revolutionizing diabetic brain hemorrhage treatment. The paper offers compelling evidence that exosomes can effectively reduce neuroinflammation and promote recovery from diabetic brain hemorrhage. Although these findings are promising, further research is warranted to fully understand the underlying mechanisms and to validate the therapeutic potential of exosomes in clinical settings.

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Role of intestinal glucagon-like peptide-1 in hypoglycemia response impairment in type 1 diabetes.

World J Diabetes

November 2024

Department of Biochemistry, School of Medicine, College of Medicine, China Medical University, Taichung City 404328, Taiwan.

This study critically examines the novel findings presented by Jin , which explores the role of intestinal glucagon-like peptide-1 (GLP-1) in impaired counterregulatory responses to hypoglycemia in mice with type 1 diabetes. The study identifies intestinal GLP-1 as a significant determinant in the physiological responses to hypoglycemia, offering new insights into its potential implications for diabetes management. The editorial synthesizes these findings, discusses their relevance in the context of current diabetes research, and outlines potential avenues for future investigation of intestinal GLP-1 as a therapeutic target.

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Application of component failure physics for the reliability assessment of an autonomous braking system.

Sci Rep

November 2024

Center for Reliability Science and Technology, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist, Taoyuan City, 333323, Taiwan.

The growing demand for Cyber-Physical Systems (CPS) requires strong reliability. However, implementing Design for Reliability (DfR) in CPS requires a deep understanding of the components' Physics of Failure. In this work, an autonomous braking system, a Cyber-Physical System is chosen to demonstrate the application of failure physics for DfR of CPS.

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Peripheral nerve sheath tumors of the hand are rare occurrences. Among them, schwannomas are benign tumors originating from peripheral nerves. In this case report, we presented a patient with schwannomas in the palm, examined using ultrasound for preoperative assessment and was confirmed by pathological specimen.

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