1 results match your criteria: "Linkou Branch Chang Gung University Taoyuan Taiwan.[Affiliation]"
Establishment of a novel gene panel as a biomarker of immune checkpoint inhibitor response.
Clin Transl Immunology
June 2020
Department of General Surgery and Liver Research Center, Chang Gung Memorial Hospital, Linkou Branch Chang Gung University Taoyuan Taiwan.
Objective: Immune checkpoint inhibitors (ICIs) have become the standard of care in various cancers, although the predictive tool is still unknown.
Methods: This study aimed to develop a novel gene panel by selecting DNA damage response (DDR) genes from the Catalogue of Somatic Mutations in Cancer (COSMIC) databank and validating them in previously reported cohorts. This association between DDR gene mutations and tumor mutation burden or microsatellite status was analysed from The Cancer Genome Atlas (TCGA) databank.