2 results match your criteria: "Linköping University Campus US[Affiliation]"
No impact of helminth coinfection in patients with smear positive tuberculosis on immunoglobulin levels using a novel method measuring Mycobacterium tuberculosis-specific antibodies.
Allergy Asthma Clin Immunol
June 2023
Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linköping University Campus US, Building 420 Floor 12, 581 85, Linköping, SE, Sweden.
Article Synopsis
- Helminth/tuberculosis (TB) coinfection can weaken the immune response to Mycobacterium tuberculosis (Mtb) and worsen disease severity, with effects varying by helminth species.
- The BCG vaccine for TB is currently available but has inconsistent effectiveness in preventing TB and its transmission.
- Recent findings show that TB patients with helminth coinfection may experience increased Mtb-specific antibody responses, but the precise impact of different helminth species on this humoral response remains unclear, necessitating further research.
IL-6 trans-Signaling Impairs Sprouting Angiogenesis by Inhibiting Migration, Proliferation and Tube Formation of Human Endothelial Cells.
Cells
June 2020
Cardiovascular Research Center, School of Medical Sciences, Örebro University Södra Grev Rosengatan 32, 703 62 Örebro, Sweden.
Sprouting angiogenesis is the formation of new capillaries from existing vessels in response to tissue hypoxia due to growth/development, repair/healing, and also chronic inflammation. In this study, we aimed to elucidate the effect of IL-6, a pleiotropic cytokine with both pro-inflammatory and anti-inflammatory functions, in regulating the sprouting angiogenic response of endothelial cells (ECs). We found that activation of IL-6 trans-signaling inhibited the migration, proliferation, and tube formation ability of ECs.
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