791 results match your criteria: "Linear IgA Dermatosis"
Cureus
May 2023
Department of Pathology, Baylor Scott & White Health, Temple, USA.
We present a rare case of linear IgA bullous dermatosis (LABD) in a 72-year-old male associated with the use of azithromycin. LABD presents as subepidermal blisters due to IgA antibodies targeting BPAG2, a component of hemidesmosomes. LABD is a rare diagnosis and may be idiopathic, associated with illness, or medication-induced.
View Article and Find Full Text PDFJ Dermatol
October 2023
Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Cureus
April 2023
Department of Dermatology, University of Florida, Gainesville, USA.
Linear IgA disease (LAD) is an uncommon autoimmune blistering disease that has been associated with medications, malignancy, and other autoimmune diseases, such as ulcerative colitis (UC). In this case report, a patient with a history of UC developed characteristic LAD lesions. While dapsone is considered first-line therapy for LAD, the treatment team opted for an underutilized, plausibly less toxic, and more simplified treatment regimen with sulfasalazine, successfully utilizing the two distinct actions of sulfasalazine's components - sulfapyridine and 5-aminosalicylate (5-ASA) - to concurrently treat both the LAD and UC symptoms.
View Article and Find Full Text PDFMo Med
April 2023
Co-Director of Thoracic Oncology, Inova Schar Cancer Institute, Fairfax, Virginia.
In the era of targeted treatments based on next generation sequencing (NGS) analysis, clinicians must be diligent in aligning patients with treatments giving them the best chance of survival while weighing the risk of toxicity caused by agents targeting specific gene mutations. In this case, we describe a patient with Epidermal Growth Factor Receptor (EGFR) exon 20 insertion mutation positive recurrent lung adenocarcinoma who received amivantamab and experienced severe dermatologic toxicity.
View Article and Find Full Text PDFCureus
March 2023
Department of Dermatology, Larkin Community Hospital, Miami, USA.
Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is an autoimmune condition with various triggers. Because of the lack of randomized controlled trials on LABD treatment, management options are mostly anecdotal. This paper provides a comprehensive review of treatment options from a literature review of reported treatments to arm clinicians with a guideline for the management of LABD in both pediatric and adult patients as well as those recalcitrant to first-line therapy (dapsone and steroids).
View Article and Find Full Text PDFCureus
February 2023
Serviço de Dermatologia, Hospital Pedro Hispano, Porto, PRT.
This is the case report of a previously healthy four-year-old girl with a history of upper airway infection that was treated with a β-lactam antibiotic. She was seen in the emergency department one month later with vesiculobullous lesions with clear content that were isolated or grouped in rosettes. Direct immunofluorescence showed baseline linear positivity for immunoglobulin A (IgA) (+) and fibrinogen-positive bullous content with absent remaining immunosera expression.
View Article and Find Full Text PDFIndian J Dermatol
January 2022
Eye Hospital, University Medical Centre Ljubljana, Slovenia.
Cicatrizing ectropion of the eyelid is an uncommon condition, possibly resulting in significant ocular morbidity. A potential cause can be a systemic disease, including autoimmune blistering disease (ABD). We herein report a case with a sixteen-year follow-up of a patient with a chronic cicatrizing unilateral ectropion caused by linear IgA bullous dermatosis (LABD).
View Article and Find Full Text PDFActa Dermatovenerol Alp Pannonica Adriat
March 2023
Department of Dermatology and Venereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Linear IgA bullous dermatosis (LABD) is a rare autoimmune bullous disease characterized by linear IgA deposition along the skin basal membrane. In children, LABD classically presents with a "cluster of jewels" appearance, whereas in adults the classic presentation is itchy papules with tense vesicles and bullae on an erythematous base. We report the case of a 41-year-old woman with LABD that we suspect was induced by acute myeloid leukemia presenting with multiple vesicles and bullae that coalesced, forming the typical clinical manifestation of LABD and confirmed with histopathological and direct immunofluorescence.
View Article and Find Full Text PDFJAAD Case Rep
April 2023
Department of Dermatology, Warren Alpert Medical School of Brown University Providence, Rhode Island.
JAAD Case Rep
February 2023
Department of Dermatology, Dr Jose N Rodriguez Memorial Hospital and Sanitarium, Caloocan City, Philippines.
Linear IgA bullous dermatosis (LABD) is a rare autoimmune/inflammatory skin condition. Here, we report on a patient who developed treatment resistant LABD. At diagnosis, elevations of IL-6 and C-reactive protein in the blood and extreme elevations of IL-6 in LABD bullous fluid were seen.
View Article and Find Full Text PDFEur J Dermatol
November 2022
Section of Dermatology, Department of health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Background: Mucous membrane pemphigoid (MMP) with anti-laminin 332 autoantibodies may be associated with malignancies, however, current serological assays have considerable limitations. At present, no commercial test for anti-laminin 332 antibodies is available, restricting the diagnosis to specialized laboratories worldwide. Biochip immunofluorescence microscopy has shown promising results in selected cohorts of laminin 332-MMP patients.
View Article and Find Full Text PDFBMC Vet Res
February 2023
Veterinary Dermatology and Dermatopathology Service, Padochov 175, 66491, Ivancice, Czech Republic.
Dermatol Online J
October 2022
Department of Dermatology, University Hospital Basel, Basel, Switzerland Kantonsspital Street Gallen und Universität Zurich, Street Gallen and Zurich, Schweiz, Switzerland.
A 4-year-old boy presented with blistering on his face and distal upper and lower extremities. Subepidermal blisters containing neutrophils and eosinophils visualized on histology supported the diagnosis of linear IgA bullous dermatosis of childhood (LABDC). The dermatosis presents with vesicles and tense blisters in an annular distribution, erythematous papules, and/or excoriated plaques.
View Article and Find Full Text PDFJ Clin Med
February 2023
Department of Dermatology and Venereology, School of Medicine, University Hospital Centre Zagreb, University of Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia.
Epidermolysis bullosa acquisita (EBA) is a rare chronic autoimmune subepidermal blistering disease of the skin and mucous membranes, usually beginning in adulthood. EBA is induced by autoantibodies to type VII collagen, a major component of anchoring fibrils in the dermal-epidermal junction (DEJ). The binding of autoantibodies to type-VII collagen subsequently leads to the detachment of the epidermis and the formation of mucocutaneous blisters.
View Article and Find Full Text PDFCureus
January 2023
Department of Rheumatology, The University of Toledo, Toledo, USA.
Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is an autoimmune disease affecting children or adults that leads to subepithelial vesiculobullous lesions on the skin and/or mucosa. Due to the histologic and clinical appearance of the disease with tense and pruritic blisters, direct immunofluorescence is required for diagnosis, which features the characteristic linear deposition of IgA autoantibodies along the basement membrane zone. LABD can be idiopathic, drug-induced, or associated with a systemic disease such as inflammatory bowel disease.
View Article and Find Full Text PDFJAAD Case Rep
March 2023
Department of Dermatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Am J Dermatopathol
March 2023
Department of Dermatology, Columbia University Irving Medical Center, New York, NY; and.
IDCases
December 2022
Department of Dermatology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya, Aichi 464-8681, Japan.
Linear IgA bullous disease (LABD) is a rare, acquired, autoimmune, pruritic, and blistering skin condition. Dapsone is a first line treatment option, however, there are limited options if this fails, or if contraindicated. We present a case of successful management of LABD with sulfasalazine.
View Article and Find Full Text PDFInt J Dermatol
February 2023
Wayne State University School of Medicine, Detroit, MI, USA.
Int J Dermatol
May 2023
Department of Dermatology, Spedali Civili, University of Brescia, Brescia, Italy.
Eur J Dermatol
September 2022
Department of Dermatology, Kagawa University Faculty of Medicine, Miki-cho, Kagawa, Japan
Case Rep Dermatol
November 2022
Department of Dermatology, Autoimmune Bullous Diseases Research Center, Razi hospital, Tehran University of Medical Sciences, Tehran, Iran.
Bullous pemphigoid is the most common acquired bullous disease with an autoimmune basis and a tendency to involve mostly old people. By rising incidence of diabetes all over the world, consumption of antidiabetes medications has also increased. One of the most used antidiabetes drugs is gliptin family (dipeptidyl-peptidase 4 inhibitor).
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