791 results match your criteria: "Linear IgA Dermatosis"
Linear IgA bullous dermatosis: 32 years of experience.
An Bras Dermatol
December 2024
Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Background: Linear IgA bullous dermatosis (LABD) is an uncommon disease with only a few reported studies in large series with long follow-up periods.
Objectives: To evaluate the clinical presentation, immunopathological features, management, and disease course in LABD patients.
Methods: Data including demographics, clinical features, histopathological and immunofluorescence findings of LABD patients, in addition to the preferred treatments and responses to treatments were evaluated.
Linear IgA/IgG bullous dermatosis presenting with refractory oral and esophageal erosions: A case report.
J Dermatol
December 2024
Department of Dermatology, Hyogo Prefectural Harima-Himeji General Medical Center, Himeji, Japan.
A Comparative Study of Direct Immunofluorescence Patterns in Linear IgA Bullous Dermatosis Versus Dermatitis Herpetiformis.
Am J Dermatopathol
November 2024
Professor and Department Chair, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC.
Article Synopsis
- - Dermatitis herpetiformis (DH) and linear IgA bullous dermatosis (LABD) are skin conditions identifiable by specific patterns of IgA deposition observed through direct immunofluorescence (DIF) testing, which may include other immunoglobulin deposits. - An analysis comparing 45 LABD cases to 48 DH cases revealed that the "picket fence pattern" was absent in LABD but present in nearly half of the DH cases, along with differences in the levels of IgG, IgM, and kappa light chains between the two conditions. - The "picket fence pattern" is a highly specific (100%) but not very sensitive (47.9%) indicator for diagnosing DH, potentially aiding clinicians
Clinical characteristics of iatrogenic versus idiopathic linear IgA bullous dermatosis: A systematic review.
J Eur Acad Dermatol Venereol
November 2024
Division of Dermatology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, USA.
Linear IgA bullous dermatosis in a latin adolescent treated with cyclosporine and prednisone.
Bol Med Hosp Infant Mex
October 2024
Pediatric Dermatology Service, General Hospital of Mexico Dr. Eduardo Liceaga, Ministry of Health. Mexico City, Mexico.
Article Synopsis
- Linear IgA bullous dermatosis (LABD) is a rare autoimmune condition typically treated with dapsone, though other immunomodulators are used if needed.
- A recent case involved a 12-year-old boy with a severe skin condition diagnosed as LABD, confirmed through biopsy, and treated effectively with prednisone and cyclosporine.
- The patient's condition improved significantly within 2 weeks, leading to further maintenance therapy with cyclosporine after initial treatments were paused due to side effects.
Uncommon and Unusual Variants of Autoimmune Bullous Diseases.
Indian Dermatol Online J
August 2024
Department of Dermatology, Venereology and Leprology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Article Synopsis
- Autoimmune blistering diseases (AIBDs) are skin conditions caused by the body's immune system attacking certain proteins, leading to blister formation, and can be categorized into intraepidermal and subepidermal types.
- The objective of this review is to raise awareness about rare and uncommon AIBD variants, such as pemphigus herpetiformis and anti-laminin 332 pemphigoid, among others.
- By discussing these unusual variants, the review aims to assist healthcare professionals in the early diagnosis and treatment of these conditions.
Drug-induced linear IgA bullous dermatosis with extensive mucosal involvement.
JAAD Case Rep
October 2024
Department of Dermatology, HCA Healthcare/USF Morsani College of Medicine GME-HCA Florida Largo Hospital, Largo, Florida.
Linear immunoglobulin A bullous dermatosis induced by atezolizumab.
Dermatol Reports
September 2024
Division of Dermatology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh.
Article Synopsis
- Linear immunoglobulin A bullous dermatosis (LABD) is a rare skin condition that causes blisters and can be triggered by infections or medications.
- Atezolizumab, a monoclonal antibody used for cancer treatment, affects a specific immune pathway.
- The text presents a case where LABD occurred as a side effect after a patient received Atezolizumab.
Histopathologic Overlap Between Bullous Lupus Erythematosus and Linear IgA Bullous Dermatosis: A Comparative Study.
Am J Dermatopathol
November 2024
Department of Pathology, St. John's Medical College, Bangalore, India .
Article Synopsis
- * This study analyzed the histopathologic characteristics of 11 cases of each disease, noting that both conditions commonly present with itchy blisters and certain similar microscopic findings, but with differences in eosinophil presence and specific epidermal changes.
- * Ultimately, the researchers concluded that histopathology is not effective for distinguishing between BLE and LAD; accurate diagnosis relies on immunofluorescence and serological tests, even when clinical signs appear typical for one condition.
Neonatal Linear Immunoglobulin A Bullous Dermatosis: A Critical Case Recovering after Prompt Recognition, Intensive Management, and Breastfeeding Interruption - A Case Report.
Neonatology
September 2024
Department Mother-Woman-Child, Clinic of Neonatology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Article Synopsis
- * A case study of a full-term female infant suffering from NLABD highlights the condition's severe cutaneous and respiratory effects, with diagnosis confirmed through skin biopsy and immunofluorescence, revealing pathogenic IgAs in the mother's breastmilk.
- * The infant successfully recovered after extensive care over 8 weeks, demonstrating the necessity for timely diagnosis and management, while presenting new insights into the role of maternal breastmilk in the disease's pathogenesis.
Histopathologic features in drug-induced, malignancy-associated, or idiopathic linear IgA bullous dermatosis: A retrospective comparative cohort study of 65 patients.
J Cutan Pathol
September 2024
Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
Addressing vancomycin adverse cutaneous reactions.
J Am Acad Dermatol
November 2024
Division of Dermatology, Cooper Medical School of Rowan University, Camden, New Jersey. Electronic address:
Case report: Dupilumab: a promising treatment option for adult linear IgA bullous dermatosis with severe pruritus.
Front Immunol
August 2024
Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China.
Article Synopsis
- Linear IgA bullous dermatosis (LABD) is an autoimmune skin disorder characterized by blistering and the presence of IgA deposits at the basement membrane.
- Diagnosis involves skin pathology tests and direct immunofluorescence to confirm the diagnosis, with symptoms including tense blisters and intense itching.
- Treatment often starts with dapsone, but in a reported case resistant to other therapies, dupilumab was used to manage itching while awaiting HLA-B*1301 gene test results to prevent serious drug reactions.
Association of recalcitrant scabies infestation and bullous pemphigoid in an infant.
Dermatol Reports
June 2024
Department of Dermatology, Ruhr-University of Bochum.
Targeted serum proteome profiling reveals nicotinamide adenine dinucleotide phosphate (NADPH)-related biomarkers to discriminate linear IgA bullous disorder from dermatitis herpetiformis.
Clin Immunol
August 2024
Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China; Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong, China; National Clinical Key Project of Dermatology and Venereology, Jinan, Shandong, China. Electronic address:
Article Synopsis
- Linear IgA bullous dermatosis (LABD) and dermatitis herpetiformis (DH) are types of autoimmune skin disorders linked to IgA, and this study aimed to explore their causes using serum proteomics.
- Researchers analyzed 92 biomarkers in serum samples from LABD, DH patients, and healthy controls, discovering elevated levels of certain biomarkers specific to these conditions.
- The study identified distinct biomarker clusters for LABD and DH, with six specific biomarkers showing potential for better prognosis in DH patients, which could help differentiate these disease subtypes in the future.
State-of-the-art diagnosis of autoimmune blistering diseases.
Front Immunol
June 2024
Department of Dermatology, Allergology and Venerology, University of Lübeck, Lübeck, Germany.
Article Synopsis
- - Autoimmune blistering disorders (AIBDs) include various conditions such as pemphigus and pemphigoid, characterized by blisters and skin lesions that can have diverse appearances, making accurate diagnosis essential for treatment and prognosis.
- - Diagnosis typically combines clinical evaluation with the detection of specific autoantibodies, utilizing tests like enzyme-linked immunosorbent assay (ELISA) and direct immunofluorescence microscopy (IFM), which is considered the gold standard.
- - Recent advancements in molecular identification of target antigens have led to new diagnostic methods and treatment approaches, enhancing the ability to detect specific antibodies related to various AIBDs.
Toxic epidermal necrolysis-like linear IgA bullous dermatosis as a manifestation of multiple drug hypersensitivity in the setting of drug reaction with eosinophilia and systemic symptoms.
JAAD Case Rep
July 2024
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York.
Airway management of a patient with linear immunoglobulin A bullous dermatosis: A case report.
World J Clin Cases
May 2024
Department of Anesthesiology, University of Florida College of Medicine, Gainesville, FL 32610, United States.
Article Synopsis
- * A 45-year-old female patient with this condition experienced significant airway bleeding during a planned corneal transplant, leading to the involvement of multiple medical specialties for her care.
- * Effective communication among the surgery, anesthesia, and dermatology teams was crucial for the patient's recovery, emphasizing that outpatient surgery is only advisable when the disease is in full remission and there is no mucous membrane involvement.
New Onset and Exacerbation of Autoimmune Bullous Dermatosis Following COVID-19 Vaccination: A Systematic Review.
Vaccines (Basel)
April 2024
Department of Dermatology, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan 33305, Taiwan.
Article Synopsis
- Autoimmune bullous dermatosis (AIBD) cases have been observed in patients after receiving COVID-19 vaccinations, prompting a systematic review of their characteristics and outcomes.
- The review analyzed 98 studies involving 229 new-onset AIBD cases (mostly bullous pemphigoid) and 216 flare cases (predominantly pemphigus), with mRNA vaccines being a common link.
- Most AIBD cases emerged within 1 to 123 days after vaccination, with many patients experiencing favorable outcomes, highlighting the need for healthcare professionals to monitor post-vaccination effects carefully.
Diagnostic Utility of Direct Immunofluorescence on Paraffin-Embedded Skin Biopsy Samples for the Diagnosis of Autoimmune Vesiculobullous Lesions.
Cureus
March 2024
Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.
Article Synopsis
- Autoimmune vesiculobullous diseases (AIBDs) are characterized by skin blisters caused by autoantibodies, and the gold standard diagnostic test is direct immunofluorescence (DIF) on fresh-frozen tissue.
- This study compared DIF using paraffin-embedded tissue (PE-DIF) to fresh-frozen tissue (FF-DIF) in 30 AIBD cases, finding that PE-DIF can detect similar patterns, particularly in pemphigus vulgaris and pemphigus foliaceous, although results can vary in intensity.
- The research concluded that while PE-DIF can supplement diagnosis in situations where frozen tissues are unavailable, it tends to deteriorate faster than FF-DIF and should
Matrix metalloproteinase-9 and neutrophil elastase from infiltrating neutrophils with neutrophil extracellular DNA traps in linear IgA bullous dermatosis: A case report.
J Dermatol
October 2024
Department of Dermatology, National Defense Medical College, Tokorozawa, Japan.
Linear IgA bullous dermatosis associated with immunotherapy.
Dermatol Online J
December 2023
Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
Article Synopsis
- Linear IgA bullous dermatosis (LABD) is a rare autoimmune skin condition characterized by blisters caused by IgA autoantibodies, and can resemble bullous pemphigoid (BP), which is due to IgG and IgE autoantibodies.
- A case study of a 67-year-old woman with metastatic ovarian cancer showed new blistering skin lesions after she started immunotherapy, which were diagnosed as LABD based on skin biopsy results.
- The patient’s condition did not improve with prednisone but significantly healed after starting dapsone, emphasizing the need for accurate diagnosis through histology and immunofluorescence to guide effective treatment without halting immunotherapy.
Linear IgA bullous dermatosis in association with nodal peripheral T cell lymphoma with a T follicular helper phenotype and multiple myeloma: a case report and literature review.
Eur J Dermatol
December 2023
Department of Dermatology, Shinshu University School of Medicine, Japan.
S2k guidelines on diagnosis and treatment of linear IgA dermatosis initiated by the European Academy of Dermatology and Venereology.
J Eur Acad Dermatol Venereol
June 2024
Department of Dermatology, Lübeck Institute of Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany.
Article Synopsis
- Linear IgA Dermatosis (LAD) is a rare autoimmune skin disease characterized by IgA deposits at the skin's basement membrane, affecting both children and adults with diverse clinical features.
- The European Academy of Dermatology and Venereology (EADV) developed consensus guidelines by collaborating with 29 experts across multiple countries to ensure a comprehensive approach to diagnosis and treatment.
- The resulting guidelines provide a combination of evidence-based and expert-based recommendations to aid dermatologists in effectively diagnosing and managing LAD.
Linear IgA Bullous Dermatosis in Korea Using the Nationwide Health Insurance Database.
J Clin Med
February 2024
Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu 42415, Republic of Korea.
Article Synopsis
- Linear immunoglobulin A bullous dermatosis (LABD) is a rare autoimmune skin disease that causes blisters and is linked to certain medications and autoimmune disorders.
- A study was conducted on 670 LABD cases in Korea from 2010 to 2022, revealing a higher incidence in people aged 60 and above, with an annual rate of 1.3 cases per 100,000 individuals.
- The findings suggested that patients were typically treated with dapsone, had an average age of diagnosis around 56 years, and had a greater association of LABD with risk factors like malignancy and antibiotic use compared to other studies.