Analyzing who is relevant to engage in environmental decision-making processes by interests, influence and impact: The 3i framework.

Outcomes in participatory environmental processes are strongly affected by choices about who is engaged. Inclusive engagement diversifies the range of interests and perspectives represented, including those from vulnerable and marginalized groups, ultimately contributing to more socially and environmentally sustainable and equitable outcomes. However, existing "stakeholder analysis" methods often bias participant identification away from disenfranchised groups with limited pre-existing interest or influence, instead favoring the most easily accessed and influential stakeholders.

Assessing the Association Between Animal Color and Behavior: A Meta-Analysis of Experimental Studies.

Color varies in pattern and degree across the tree of life. In animals, genetic variation in color is hypothesized to have pleiotropic effects on a variety of behaviors due to shared dependence on underlying biochemical pathways. Such pleiotropy can constrain the independent evolution of color and behavior.

Dissecting metabolic landscape of alveolar macrophage.

The highly plastic nature of Alveolar Macrophage (AM) plays a crucial role in the defense against inhaled particulates and pathogens in the lungs. Depending on the signal, AM acquires either the classically activated M1 phenotype or the alternatively activated M2 phenotype. In this study, we investigate the metabolic shift in the activated phases of AM (M1 and M2 phases) by reconstructing context specific Genome-Scale Metabolic (GSM) models.

The occurrence and persistence of surface water contaminants across different landscapes.

Surface water contaminants, including both conventional contaminants (e.g., nutrients, trace elements) and emerging contaminants (e.

Assessment of Intermolecular Hydrogen Bonds in the Compact Self-Assemblies of 1,3,5-Tris(4-carboxyphenyl)benzene Molecules on Au(111).

The self-assembly of star-shaped 1,3,5-tris(4-carboxyphenyl)benzene molecules on Au(111) is investigated by using scanning tunneling microscopy (STM) and density functional theory (DFT) calculations. STM shows that for one monolayer deposition, the molecules self-assemble into two compact nanoarchitectures: one with a rectangular unit cell and a second one with a parallelogram unit cell. DFT calculations reveal that these two compact structures are stabilized by hydrogen bonds and that the rectangular nanoarchitecture has the lowest energy.

Mechanism of Ampicillin Hydrolysis by New Delhi Metallo-β-Lactamase 1: Insight From QM/MM MP2 Calculation.

The New Delhi metallo-β-lactamase 1 (NDM-1) can hydrolyze nearly all clinically important β-lactam antibiotics, narrowing the options for effective treatment of bacterial infections. QM/MM MP2 calculations are performed to reveal the mechanism of ampicillin hydrolysis catalyzed by NDM-1. It is found that the rate-determining step is the dissociation of hydrolyzed ampicillin from the NDM-1 active site, which requires a proton transfer from the bridging neutral water molecule to the newly formed carboxylate group.

Tethered release of the pseudorabies virus deubiquitinase from the capsid promotes enzymatic activity.

Unlabelled: Herpesviruses carry an assortment of proteins in the interstitial space between the capsid and membrane envelope, collectively referred to as the tegument. Upon virion fusion with a cell, envelope integrity is disrupted, and many tegument constituents disperse into the cytosol to carry out individual effector functions, while others direct transport of the capsid to the nucleus. To gain insight into the tegument dynamics that occur with disruption of envelope integrity, we used a combination of single-particle fluorescence and biochemical approaches that leveraged the previously established use of n-ethylmaleimide to inhibit virion dynamics.

Compound-Specific Isotope Analysis as a Potential Approach for Investigation of Cerebral Accumulation of Docosahexaenoic Acid: Previous Milestones and Recent Trends.

Docosahexaenoic acid (DHA, C22:6 n-3), a predominant omega-3 polyunsaturated fatty acid in brain, plays a vital role in cerebral development and exhibits functions with potential therapeutic effects (synaptic function, neurogenesis, brain inflammation regulation) in neurodegenerative diseases. The most common approaches of studying the cerebral accretion and metabolism of DHA involve the use of stable or radiolabeled tracers. Although these methods approved kinetic modeling of ratios and turnovers for fatty acids, they are associated with excessive costs, restrictive studies, and singular dosing effects.

Mystery on the Bounty: The family-level status of Pacificana cockayni Hogg, 1904 (Araneae).

The family-level placement of the species Pacificana cockayniHogg, 1904 (Araneae, Miturgidae) has been ambiguous for over a century, with the monotypic genus Pacificana initially placed in Agelenidae, later transferred to Amaurobioidinae (Anyphaenidae), and presently in Miturgidae. A recent work describing the male and molecular data consisting of a single mitochondrial gene, cytochrome c oxidase subunit I, confirmed that the species is part of the marronoid clade; however, these data did not result in a conclusive family-level placement. Here, we use low-coverage whole genome sequencing (lcWGS) combined with data from the Sequence Read Archive to infer a phylogeny from ultraconserved elements (UCEs) and six legacy Sanger loci.

Withdrawal Signs and Symptoms Among Patients Positive for Fentanyl With and Without Xylazine.

Background: Xylazine is not approved for human use, yet it has emerged as a common adulterant of illicit fentanyl. It is currently unclear whether there is a withdrawal syndrome associated with xylazine and the potential impact of fentanyl coexposure.

Methods: A retrospective cohort study of patients with opioid use disorder admitted to an inpatient medically monitored withdrawal facility was performed.

Scaling and merging time-resolved pink-beam diffraction with variational inference.

Time-resolved x-ray crystallography (TR-X) at synchrotrons and free electron lasers is a promising technique for recording dynamics of molecules at atomic resolution. While experimental methods for TR-X have proliferated and matured, data analysis is often difficult. Extracting small, time-dependent changes in signal is frequently a bottleneck for practitioners.

Reducing Uncertainty of Groundwater Redox Condition Predictions at National Scale, for Decision Making and Policy.

Understanding hydrogeochemical heterogeneity, associated with natural nitrate attenuation, is an integral part of implementing integrated land and water management on a regional or national scale. Redox conditions are a key indicator of naturally occurring denitrification in the groundwater environment, and often used to inform spatial planning and targeted regulation. This work describes the development of a statistical redox condition model for the groundwater environment at a national scale, using spatially variable physiochemical descriptors as predictors.

Smac/DIABLO protein acts as an independent prognostic factor in oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) poses significant health risks with increasing incidence and mortality rates. In this context, there is an urgent need to explore novel biomarkers to enhance therapeutic strategies and improve survival. Understanding apoptotic evasion in cancer pathogenesis, this pioneering study aims to investigate the correlation between a pro-apoptotic protein Smac/DIABLO and patient prognosis within the OSCC cohort.

Establishing a comprehensive web-based analysis platform for Nicotiana benthamiana genome and transcriptome.

Nicotiana benthamiana has long served as a crucial plant material extensively used in plant physiology research, particularly in the field of plant pathology, because of its high susceptibility to plant viruses. Additionally, it serves as a production platform to test vaccines and other valuable substances. Among its approximately 3.

Heart Rate Variability, Hypnosis, and Psychotherapy.

Hypnotherapy is increasingly recognized as an effective treatment option for a wide range of psychological conditions and the psychological elements of physiologic health concerns. Despite its growing use, the mechanisms underlying hypnotherapy's therapeutic benefits remain unknown. Heart rate variability (HRV), a non-invasive biomarker of autonomic nervous system (ANS) activity and other processes relevant to the psychophysiological stress response, has been used to study the physiological effects of hypnosis.