2 results match your criteria: "LifeNet Health Institute of Regenerative Medicine[Affiliation]"

Human placenta hydrogel reduces scarring in a rat model of cardiac ischemia and enhances cardiomyocyte and stem cell cultures.

Acta Biomater

April 2017

Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, United States; Department of Electrical and Computer Engineering, Old Dominion University, Norfolk, VA, United States. Electronic address:

Introduction: Xenogeneic extracellular matrix (ECM) hydrogels have shown promise in remediating cardiac ischemia damage in animal models, yet analogous human ECM hydrogels have not been well development. An original human placenta-derived hydrogel (hpECM) preparation was thus generated for assessment in cardiomyocyte cell culture and therapeutic cardiac injection applications.

Methods And Results: Hybrid orbitrap-quadrupole mass spectrometry and ELISAs showed hpECM to be rich in collagens, basement membrane proteins, and regenerative growth factors (e.

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Article Synopsis
  • Developed osteoinductive, micro-fibrous demineralized bone matrix (DBM) fibers for creating custom 3D implants to improve bone repair and reduce construction time.
  • Mechanically strong DBM scaffolds demonstrated effective attachment and metabolic activity of mesenchymal stem cells, and promoted bone growth in animal models.
  • These pre-formed implants offer a personalized approach to orthopedic surgeries, potentially enhancing patient outcomes and advancing regenerative medicine techniques.
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