170 results match your criteria: "Life Sciences Research Institute[Affiliation]"

The white-backed planthopper (WBPH) poses a significant threat to rice crops globally. A bioassay was conducted on three WBPH populations collected from Korean rice fields to assess the effectiveness of five insecticides, including etofenprox and fenobucarb. The results showed a mortality rate of over 97% at the recommended concentration for carbamate and organophosphate insecticides.

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Development of a SYBR Green Real-Time PCR method for the detection of and using chloroplast genes.

Food Sci Biotechnol

January 2025

Agriculture and Life Sciences Research Institute, Kangwon National University, Chuncheon, Republic of Korea.

Unlabelled: (Arabica) and (Robusta) are valuable agricultural products traded worldwide. In this study, we designed specific primer pairs for Arabica and Robusta using chloroplast genes to distinguish and quantify the two types of coffee beans. We assessed the specificity, sensitivity, and applicability of the qRT-PCR assay using all the primer pairs.

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Evidence that myelin repair is crucial for functional recovery in multiple sclerosis (MS) led to the identification of bexarotene (BXT). This clinically promising remyelinating agent activates multiple nuclear hormone receptor subtypes implicated in myelin repair. However, BXT produces unacceptable hyperlipidemia.

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Since the commercialization of diamide insecticides, including chlorantraniliprole, in 2007, the overuse of diamide insecticides for over a decade has resulted in excessive chlorantraniliprole resistance in , causing continuous economic losses. While RyR target-site mutations and detoxification enzymes such as cytochrome P450 have been studied as the leading causes of resistance, previous studies, including functional research and synergistic tests, have not confirmed a clear correlation between these factors and the development of resistance. Thus, transcriptome analysis was employed to investigate alternative strategies beyond mutation(s) in RyR or metabolic factors involving detoxification pathways that allow diamide-resistance to counteract the calcium ion imbalances induced by chlorantraniliprole effectively.

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Rice is a staple crop in Asia, with more than 400 million tons consumed annually worldwide. The protein content of rice is a major determinant of its unique structural, physical, and nutritional properties. Chemical analysis, a traditional method for measuring rice's protein content, demands considerable manpower, time, and costs, including preprocessing such as removing the rice husk.

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The transmembrane protein known as the mitochondrial calcium uniporter (MCU) mediates the influx of calcium ions (Ca) into the mitochondrial matrix. An overload of mitochondrial Ca ( Ca) is directly linked to damaging effects in pathological conditions. Therefore, inhibitors of the MCU are important chemical biology tools and therapeutic agents.

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Genome sequence data of the contemporary fresh-market tomatoes.

BMC Genom Data

July 2024

Horticultural Sciences Department, University of Florida, Gainesville, FL, USA.

Article Synopsis
  • - The study focuses on the fresh-market tomato (Solanum lycopersicum), which has been specifically bred for human consumption, and highlights recently identified genetic variations that impact tomato yields but lack thorough examination.
  • - Researchers have sequenced the whole genomes of 81 tomato varieties, including 68 contemporary fresh-market types and 13 breeding accessions, using advanced Illumina sequencing technology for detailed genetic analysis.
  • - The resulting genome sequence data aims to provide valuable resources for genetic research and breeding efforts, ultimately enhancing the understanding of traits important for fresh-market tomato production and quality.
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Targeting low levels of MIF expression as a potential therapeutic strategy for ALS.

Cell Rep Med

May 2024

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B. 653, Beer Sheva 84105, Israel; The School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, P.O.B. 653, Beer Sheva 84105, Israel. Electronic address:

Article Synopsis
  • Mutations in the SOD1 gene are linked to amyotrophic lateral sclerosis (ALS), leading to the loss of motor neurons and associated symptoms.
  • Researchers found that injecting macrophage migration inhibitory factor (MIF) into SOD1 mice improves motor function, slows down ALS progression, and increases survival by reducing SOD1 misfolding and neuroinflammation.
  • Low levels of MIF were observed in both stem cell-derived motor neurons from ALS patients and in the tissues of deceased sporadic ALS patients, suggesting that MIF could be a potential therapy for ALS.
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Citrus fruits were sorted based on external qualities, such as size, weight, and color, and internal qualities, such as soluble solid content (SSC), acidity, and firmness. Visible and near-infrared (VNIR) hyperspectral imaging techniques were used as rapid and nondestructive techniques for determining the internal quality of fruits. The applicability of the VNIR hyperspectral imaging technique for predicting the SSC in citrus fruits was evaluated in this study.

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Ginsenosides Rh1, Rg2, and Rg3 ameliorate dexamethasone-induced muscle atrophy in C2C12 myotubes.

Food Sci Biotechnol

April 2024

Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon, 24341 Republic of Korea.

High doses or prolonged use of the exogenous synthetic glucocorticoid dexamethasone (Dex) can lead to muscle atrophy. In this study, the anti-atrophic effects of ginsenosides Rh1, Rg2, and Rg3 on Dex-induced C2C12 myotube atrophy were assessed by XTT, myotube diameter, fusion index, and western blot analysis. The XTT assay results showed that treatment with Rh1, Rg2, and Rg3 enhanced cell viability in Dex-injured C2C12 myotubes.

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The prevalence of adolescent obesity in the Middle-East is considered among the highest in the world. Obesity in adolescents is associated with several cardiometabolic abnormalities, the constellation of which is referred to as the metabolic syndrome (MetS). This multi-country cross-sectional study aims to determine the optimal cut-off values for body fat (BF); body mass index (BMI) z-score; waist circumference (WC) percentile, and mid-upper arm circumference (MUAC) for the prediction of MetS among adolescents from Kingdom of Saudi-Arabia (KSA), Kuwait, Jordan, Lebanon and Syria.

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Although it is evident that PM has serious adverse health effects, there is no consensus on what the biologically effective dose is. In this study, the intrinsic oxidative potential (OPm) and the extrinsic oxidative potential (OPv) of PM were measured using three chemical assays including dithiothreitol (DTT), ascorbic acid (AA), and reduced glutathione (GSH), along with chemical compositions of PM in South Korea. Among the three chemical assays, only OPm showed a statistically significant correlation with PM while OPm and OPm were not correlated with PM mass concentration.

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. The existing diagnostic paradigm for diabetic retinopathy (DR) greatly relies on subjective assessments by medical practitioners utilizing optical imaging, introducing susceptibility to individual interpretation. This work presents a novel system for the early detection and grading of DR, providing an automated alternative to the manual examination.

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Apples are widely cultivated in the Republic of Korea and are preferred by consumers for their sweetness. Soluble solid content (SSC) is measured non-destructively using near-infrared (NIR) spectroscopy; however, the SSC measurement error increases with the change in apple size since the distance between the light source and the near-infrared sensor is fixed. In this study, spectral characteristics caused by the differences in apple size were investigated.

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Article Synopsis
  • Many species of red algae in the Rhodophyta phylum are important for human nutrition and medicine, with recent advancements in their classification accuracy.
  • The study analyzes the complete chloroplast and mitochondrial genomes of three laver species - Neoporphyra dentata, Neoporphyra seriata, and Neopyropia yezoensis - aiming to characterize their genetic organization and develop molecular markers.
  • Findings include an average of 212 protein-coding genes in the chloroplast and 25 in the mitochondria of the species, along with the creation of 12 species-specific markers to help distinguish these species in research and industry.
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Exaptation of I4760M mutation in ryanodine receptor of Spodoptera exigua (Lepidoptera: Noctuidae): Lessons from museum and field samples.

Pestic Biochem Physiol

September 2023

Interdisciplinary Graduate Program in Smart Agriculture, Kangwon National Unversity, Chuncheon 24341, Republic of Korea; Agriculture and Life Sciences Research Institute, Kangwon National University, Chuncheon 24341, Republic of Korea; Department of Plant Medicine, Kangwon National University, Chuncheon 24341, Republic of Korea. Electronic address:

Since 2007, diamide insecticides have been widely used in Korea to control various types of lepidopteran pests including Spodoptera exigua. For nearly a decade, diamide resistance in field populations of S. exigua across 18 localities has been monitored using bioassays.

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Aims: The objective of this study was to characterize the pharmacokinetics (PK)/pharmacodynamics (PD) of DWP16001, a novel sodium-glucose cotransporter 2 inhibitor, and predict efficacious doses for the first-in-human study using various translational approaches.

Methods: A mechanistic PK/PD model was developed for DWP16001 using nonlinear mixed-effect modelling to describe animal PK/PD properties. Using allometry and in silico physiologically based equations, human PK parameters were predicted.

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Improvement of analytical method for three azo dyes in processed milk and cheese using HPLC-PDA.

Food Chem X

June 2023

Department of Food Biotechnology and Environmental Science, Kangwon National University, Chuncheon 24341, Republic of Korea.

This study aims to develop and validate a method for simultaneously measuring three azo dyes (azorubine, brilliant black BN, lithol rubine BK) not designated in Korea. The HPLC-PDA analysis method was validated based on the ICH guidelines, and the color stability was evaluated. The milk and cheese samples were spiked with azo dyes, the correlation coefficient of calibration curve ranged from 0.

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Power augmentation in a small-scale horizontal axis wind turbine, with its rotor encased in a flanged diffuser is explored. The power output of the wind turbine varies with changes in the diffuser design and the resulting back pressure. Reduction in this back pressure also results in early flow separation at the diffuser surface, which hinders turbine performance.

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The fall armyworm (, FAW) is an invasive migratory pest that has recently spread to Korea, damaging several corn cultivars with significant economic value. Comparisons of the growth stages of FAW were conducted based on the preferred feed. Therefore, we selected six maize cultivars, including three categories: (i) commercial waxy corn (mibaek 2-ho, heukjeom 2-ho, dreamoak); (ii) popcorn (oryun popcorn, oryun 2-ho); and (iii) processing corn (miheukchal).

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, commonly named Asian blue cohosh, is a perennial herb in the family Berberidaceae. It has traditionally been used for folk medicine in China. We isolated berberine from the leaves, stem, roots, and fruits of , and this is the first report on berberine in this species.

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is native to Southeast Asia and has emerged as a major vector for vector-borne diseases that are spreading rapidly worldwide. Recent studies have shown that populations have different genetic groups dependent on their thermal adaptations; however, studies on Korean populations are limited. In this study, we analyzed the genetic diversity and structure of two mitochondrial genes ( and ) and sixteen microsatellites in mosquitoes inhabiting Korea, Japan, and Laos.

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Due to climate change, soil moisture may increase, and outflows could become more frequent, which will have a considerable impact on crop growth. Crops are affected by soil moisture; thus, soil moisture prediction is necessary for irrigating at an appropriate time according to weather changes. Therefore, the aim of this study is to develop a future soil moisture (SM) prediction model to determine whether to conduct irrigation according to changes in soil moisture due to weather conditions.

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A Tungsten-Halogen (TH) lamp is the most popular light source in NIR spectroscopy and hyperspectral imaging, which requires a warm-up to reach very high temperatures of up to 250 °C and take a long time for radiation stabilization. Consequently, it has a large enough volume to enable heat dissipation to prevent the thermal runaway of the electric circuit and turn out its power efficiency very low. These are major barriers for miniaturizing spectral systems and hyperspectral imaging devices.

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