What can stimulus polarity and interphase gap tell us about auditory nerve function in cochlear-implant recipients?

Modeling studies suggest that differences in neural responses between polarities might reflect underlying neural health. Specifically, large differences in electrically evoked compound action potential (eCAP) amplitudes and amplitude-growth-function (AGF) slopes between polarities might reflect poorer peripheral neural health, whereas more similar eCAP responses between polarities might reflect better neural health. The interphase gap (IPG) has also been shown to relate to neural survival in animal studies.

A Comparison of Alternating Polarity and Forward Masking Artifact-Reduction Methods to Resolve the Electrically Evoked Compound Action Potential.

Objective: Cochlear implant manufacturers utilize different artifact-reduction methods to measure electrically evoked compound action potentials (ECAPs) in the clinical software. Two commercially available artifact-reduction techniques include forward masking (FwdMsk) and alternating polarity (AltPol). AltPol assumes that responses to the opposing polarities are equal, which is likely problematic.

Pitch ranking, electrode discrimination, and physiological spread of excitation using current steering in cochlear implants.

The first objective of this study was to determine whether adaptive pitch-ranking and electrode-discrimination tasks with cochlear-implant (CI) recipients produce similar results for perceiving intermediate "virtual-channel" pitch percepts using current steering. Previous studies have not examined both behavioral tasks in the same subjects with current steering. A second objective was to determine whether a physiological metric of spatial separation using the electrically evoked compound action potential spread-of-excitation (ECAP SOE) function could predict performance in the behavioral tasks.

Effect of electrode impedance on spread of excitation and pitch perception using electrically coupled "dual-electrode" stimulation.

Objectives: In newer-generation Cochlear Ltd. cochlear implants, two adjacent electrodes can be electrically coupled to produce a single contact or "dual electrode" (DE). The goal of the present study was to evaluate whether relatively large impedance differences (>3.

Pitch ranking, electrode discrimination, and physiological spread-of-excitation using Cochlear's dual-electrode mode.

This study compared pitch ranking, electrode discrimination, and electrically evoked compound action potential (ECAP) spatial excitation patterns for adjacent physical electrodes (PEs) and the corresponding dual electrodes (DEs) for newer-generation Cochlear devices (Cochlear Ltd., Macquarie, New South Wales, Australia). The first goal was to determine whether pitch ranking and electrode discrimination yield similar outcomes for PEs and DEs.

Performance outcomes for borderline cochlear implant recipients with substantial preoperative residual hearing.

Objective: This study examined whether cochlear implant (CI) recipients with substantial preoperative residual hearing obtained more benefit from a CI than from a hearing aid (HA).

Study Design: Retrospective records review.

Setting: Tertiary referral center.

ECAP spread of excitation with virtual channels and physical electrodes.

The primary goal of this study was to evaluate physiological spatial excitation patterns for stimulation of adjacent physical electrodes and intermediate virtual channels. Two experiments were conducted that utilized electrically evoked compound action potential (ECAP) spread-of-excitation (SOE) functions obtained with the traditional forward-masking subtraction method. These two experiments examined spatial excitation patterns for virtual-channel maskers and probes, respectively.

Temporal response properties of the auditory nerve: data from human cochlear-implant recipients.

The primary goal of this study was to characterize the variability in auditory-nerve temporal response patterns obtained with the electrically evoked compound action potential (ECAP) within and across a relatively large group of cochlear-implant recipients. ECAPs were recorded in response to each of 21 pulses in a pulse train for five rates (900, 1200, 1800, 2400, and 3500 pps) and three cochlear regions (basal, middle, and apical). An alternating amplitude pattern was typically observed across the pulse train for slower rates, reflecting refractory properties of individual nerve fibers.

Effect of stimulus and recording parameters on spatial spread of excitation and masking patterns obtained with the electrically evoked compound action potential in cochlear implants.

Objectives: Spread of excitation within the cochlea in response to electrical stimulation can be measured with the electrically evoked compound action potential (ECAP). Different spread of excitation measurement techniques have been reported in the literature. One method uses a fixed stimulus location while varying the recording electrode along the length of the implanted array.

Psychophysical and physiological measures of electrical-field interaction in cochlear implants.

The primary purpose of this study was to determine whether the electrically evoked compound action potential (ECAP) can be used to predict psychophysical electrical-field interaction patterns obtained with simultaneous stimulation of intracochlear electrodes. The second goal was to determine whether ECAP patterns are affected by recording location because differences might influence the relation between ECAP and psychophysical measures. The third goal was to investigate whether symmetrical threshold shifts are produced with phase inversion of the interaction stimulus.

A re-evaluation of the relation between physiological channel interaction and electrode pitch ranking in cochlear implants.

Spatial excitation patterns in cochlear implant users can be measured with the electrically evoked compound action potential (ECAP). This study examined whether the relative separation of ECAP excitation patterns for two electrodes was correlated with the ability to discriminate those electrodes on the basis of pitch. Significant correlations were found for nine of the ten subjects.

Psychophysical versus physiological spatial forward masking and the relation to speech perception in cochlear implants.

Objectives: The primary goal of this study was to determine if physiological forward masking patterns in cochlear implants are predictive of psychophysical forward masking (PFM) patterns. It was hypothesized that the normalized amount of physiological masking would be positively correlated with the normalized amount of psychophysical masking for different masker-probe electrode separations. A secondary goal was to examine the relation between the spatial forward masking patterns and speech perception performance.

Effects of elicitation task variables on speech production by children with cochlear implants.

Given the interest in comparing speech production development in children with normal hearing and hearing impairment, it is important to evaluate how variables within speech elicitation tasks can differentially affect the acoustics of speech production for these groups. In a first experiment, children (6-14 years old) with cochlear implants produced a set of monosyllabic words either in isolation or while simultaneously signing the word. Acoustical analyses indicated no change in word duration, voice onset time, intensity, or fundamental frequency between isolated and simultaneous signing conditions.