2,023 results match your criteria: "Lichen Simplex Chronicus"
Efficacy of dupilumab in chronic prurigo: A multicentre retrospective study.
Ann Dermatol Venereol
December 2024
Department of Dermatology, University Hospital of Nancy, France. Electronic address:
An Observational Study on Female Genital Dermatoses and the Impact of Chronic Genital Dermatoses on Quality of Life in Adult Females.
Indian J Dermatol
October 2024
From the Department of Dermatology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Background: Female genital dermatoses (FGD) or vulvar dermatoses are a group of disorders that affect the vulva and contiguous parts. Most of the FGDs can be chronic or recurrent. Effects on Quality of life (QoL) in patients having dermatological conditions are well studied but this is not the case in vulvar dermatoses.
View Article and Find Full Text PDFPrecancerous Lesions of HPV-independent Vulvar Squamous Cell Carcinoma: Clinicopathologic Consideration of an Evolving Spectrum.
Adv Anat Pathol
November 2024
Department of Pathology, University of California San Diego, San Diego, CA.
Article Synopsis
- HPV-independent squamous cell carcinomas are the most common type of vulvar cancer, but their precancerous lesions are infrequently seen in clinical practice.
- Differentiated vulvar intraepithelial neoplasia (dVIN) is the main precancerous lesion associated with a high risk of progression and is often linked to lichen sclerosus, with a significant number showing TP53/p53 abnormalities.
- The review discusses various related lesions and emphasizes updates in terminology, diagnostics, biomarkers, and the underlying processes of these precancerous conditions.
Comprehensive analysis of Hibisci mutabilis Folium extract's mechanisms in alleviating UV-induced skin photoaging through enhanced network pharmacology and experimental validation.
Front Pharmacol
October 2024
Department of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.
Background: Skin photoaging induced by ultraviolet A (UVA) and ultraviolet B (UVB) radiation manifests as skin roughness, desquamation, pigmentation, and wrinkle formation. Current treatments, such as sunscreen, hormones, and antioxidants, have limitations and side effects. Traditional Chinese Medicine Hibisci Mutabilis Folium (HMF), or Mu-Fu-Rong-Ye in Chinese name, refers to the dried leaves of the plant L.
View Article and Find Full Text PDF[Medical clinical diagnostics for indoor mould exposure - Update 2023 (AWMF Register No. 161/001)].
Pneumologie
October 2024
Labor Dr. Wisplinghoff.
This article is an abridged version of the updated AWMF mould guideline "Medical clinical diagnostics in case of indoor mould exposure - Update 2023", presented in July 2023 by the German Society of Hygiene, Environmental Medicine and Preventive Medicine (Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin, GHUP), in collaboration with German and Austrian scientific medical societies, and experts. Indoor mould growth is a potential health risk, even if a quantitative and/or causal relationship between the occurrence of individual mould species and health problems has yet to be established. There is no evidence for a causal relationship between moisture/mould damage and human diseases, mainly because of the ubiquitous presence of fungi and hitherto inadequate diagnostic methods.
View Article and Find Full Text PDFFrom Compression to Itch: Exploring the Link Between Nerve Compression and Neuropathic Pruritus.
Am J Clin Dermatol
October 2024
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Article Synopsis
- * It often manifests in specific forms such as brachioradial pruritus in the forearms, notalgia paresthetica in the upper back, and anogenital itch, which can be related to spine problems.
- * Treatment may involve topical remedies or systemic medications, but currently, there are no FDA-approved options specifically for neuropathic itch, making it essential to understand its neural causes for effective management.
Lichen simplex chronicus of the scalp: A clinical and trichoscopic perspective.
Indian J Dermatol Venereol Leprol
January 2024
Department of Dermatology, Venereology and Leprology, PGIMER, Chandigarh, India.
A Preliminary Study Using High-Frequency Ultrasound to Evaluate Vulvar Skin With Lichenoid Vulvar Dermatoses.
Skin Res Technol
September 2024
Zhengzhou University People's Hospital, Zhengzhou, China.
Article Synopsis
- Lichenoid vulvar dermatoses (LVD) are inflammatory conditions that affect the vulva and anus, and this study explores skin changes in patients with LVD using high-frequency ultrasound.
- The study involved 45 LVD patients categorized into vulvar lichen sclerosus (VLS) and vulvar lichen simplex chronicus (VLSC) groups, along with a control group of healthy women, measuring various skin thicknesses and vascularity.
- Results showed increased skin thickness and vascular indices in LVD patients compared to controls, with high-frequency ultrasound proving useful for evaluating LVD and identifying allergic diseases as a significant risk factor for VLS.
Healthcare resource utilization and related cost among hospitalized patients with prurigo nodularis: a retrospective cohort study using Italian health claims data.
Ital J Dermatol Venerol
October 2024
Dermatologic Clinic, Department of Medicine and Aging Science and Dermatologic Clinic, G. d'Annunzio University, Chieti, Italy.
Article Synopsis
- Prurigo nodularis (PN) is a chronic skin condition causing severe itching, and this study aimed to assess its impact on healthcare costs and resource use in Italy.
- The research analyzed data from 295 hospitalized PN patients and matched them with 590 non-PN individuals, revealing significant differences in comorbidities and healthcare resource consumption over a one-year follow-up period.
- PN patients had much higher healthcare costs, averaging €3847 compared to €711 for non-PN controls, primarily due to increased medication prescriptions, hospitalizations, and outpatient services.
Introducing the Bender sign for the diagnosis of intergluteal cleft skin disorders.
Clin Dermatol
August 2024
Private Practice, Pembroke Pines, Florida, USA. Electronic address:
Article Synopsis
- - Dr. Benjamin Bender (1908-1996) was a Clinical Professor of Dermatology and is known for creating the "Bender sign," a humorous method for diagnosing skin diseases in the gluteal cleft.
- - The Bender sign involves patients bending over so doctors can manually inspect the area, emphasizing the need to check for skin conditions like psoriasis.
- - A second sign, "Bender sign #2," relates to the observation that the nose remains unaffected during neurodermatitis inflammation, showcasing Bender's impact as a beloved educator in dermatology.
Vulvar lichen simplex chronicus presenting as recurrent itchy gray papules.
Am J Obstet Gynecol
August 2024
Department of Dermatology, Mayo Clinic, Scottsdale, AZ; Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ. Electronic address:
Efficacy and feasibility analysis of compound fluocinolone acetonide cream combined with guaiazulene in the treatment of neurodermatitis.
Arch Dermatol Res
August 2024
Department of Dermatology, Geriatric Hospital Affiliated with Wuhan University of Science and Technology, No. 6, Huangjiahu Road, Wuhan, 430065, Hubei Province, China.
Article Synopsis
- A study was conducted on 92 patients with neurodermatitis to evaluate the effects of a combined treatment using fluocinolone acetonide cream and guaiazulene compared to fluocinolone alone.
- Results showed that the experimental group experienced significant improvements in skin symptoms, reduced itching scores, and a faster onset of treatment effects.
- Although both treatments had similar overall efficacy rates, the quality of life for the experimental group improved more significantly, and they had fewer adverse reactions.
Solitary verrucous plaque on a leg.
Int J Dermatol
August 2024
Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Article Synopsis
- A 70-year-old woman had a single wart-like growth on her leg and painful sores in her mouth.
- Doctors considered possible conditions like lichen simplex chronicus and chromoblastomycosis before diagnosing her with pemphigus vegetans (PVeg).
- This case emphasizes the need to include PVeg in diagnoses for unusual skin growths, even when they appear in unexpected areas of the body.
Environmental Influences on Atopic Eczema.
J Environ Sci Public Health
June 2024
Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona CA 91766, USA.
Article Synopsis
- Health outcomes are influenced by both genetics and environmental factors, impacting diseases like atopic eczema, which is a common chronic skin condition.
- Atopic eczema affects 2.5%-3.5% of adults and 10%-15% of children in Western industrialized countries, with rising cases suggesting links to environmental changes rather than just genetics.
- Understanding the environmental triggers of atopic eczema could help identify its causes and lead to potential prevention strategies.
A Feasibility Study Investigating a Topical Preparation as Novel Adjunct Treatment for the Symptomatic Management of Vulvovaginal Skin Conditions.
Womens Health Rep (New Rochelle)
May 2024
The Pelvic Medicine Center, St Andrew's War Memorial Hospital, Brisbane, Australia.
Article Synopsis
- The study examined a new topical gel for treating vulvovaginal skin conditions in women, focusing on its feasibility and effectiveness.
- Fifty-two women with conditions like lichen sclerosus and genitourinary syndrome applied the gel daily for up to two years, with positive outcomes measured short-term and long-term.
- Results showed significant symptom improvement, high patient compliance, and no reported adverse effects, suggesting the gel could be a beneficial treatment option.
Simultaneous Muraine Sutures and Excimer Laser-Assisted Penetrating Keratoplasty for Acute Keratoconus.
J Clin Med
June 2024
Department of Ophthalmology, UMH, Martin-Luther-University Halle-Wittenberg, 06120 Halle (Saale), Germany.
Article Synopsis
- Acute keratoconus, affecting 1.6-2.8% of keratoconus patients, leads to corneal issues due to fluid entering through a tear in Descemet's membrane, requiring quick intervention.
- A new surgical approach combining Muraine corneal sutures with Excimer laser-assisted penetrating keratoplasty was tested on six patients, leading to significant improvements in visual acuity post-surgery.
- Follow-up results showed stable visual outcomes, with one patient experiencing graft rejection, emphasizing the need for specialized care for patients with a history of neurodermatitis.
A cross-sectional study of noninfectious - nonvenereal genital dermatoses among adult males at tertiary care hospital in South Gujarat.
Indian J Sex Transm Dis AIDS
June 2024
Department of Dermatology, Venereology and Leprology, Government Medical College, Surat, Gujarat, India.
Article Synopsis
- - The study focuses on noninfectious and nonvenereal dermatoses affecting the genital area, which can also impact other body parts and are not sexually transmitted.
- - It involved 261 adult patients who were examined and diagnosed through detailed history, physical exams, and biopsies over a year, with a significant number having conditions like vitiligo and lichen simplex chronicus.
- - The results indicated that the majority of participants were middle-aged men, with 78.54% having genital-only dermatoses, making this research unique for its specific demographic and focus in India.
Genetic analyses unravel the causal association of cytokine levels on lichen simplex chronicus risk: insights from a mendelian randomization study.
Arch Dermatol Res
May 2024
School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, P. R. China.
Article Synopsis
- Lichen simplex chronicus (LSC) is a challenging skin condition with unclear causes, prompting a study to explore the role of inflammatory cytokines using Mendelian randomization.
- The research found that certain genetically determined cytokine levels, specifically MMP-10 and DNER, may reduce the risk of LSC, while higher GDNF levels were linked to an increased prevalence of the condition.
- The study established robust causal relationships and suggested that understanding these cytokines could lead to new research directions, although more validation is needed.
AWMF mold guideline "Medical clinical diagnostics for indoor mold exposure" - Update 2023 AWMF Register No. 161/001.
Allergol Select
May 2024
Laboratory Dr. Wisplinghoff.
Article Synopsis
- This text lacks any provided content or specific information.
- Without details, it is impossible to summarize or draw key points.
- For a meaningful synopsis, additional context or a defined topic is needed.
Dermoscopy to differentiate clinically similar inflammatory and neoplastic skin lesions.
Ital J Dermatol Venerol
April 2024
Institute of Dermatology, Santa Maria della Misericordia University Hospital, Udine, Italy -
Article Synopsis
- - Dermoscopy is a valuable imaging technique for dermatologists that helps distinguish between neoplastic (tumor-related) and inflammatory skin conditions, especially in tricky cases where they may appear similar.
- - A review of literature identified key dermoscopic features that can aid in differentiating 12 common challenging skin scenarios, such as distinguishing between Bowen's disease and psoriasis.
- - The study concludes that dermoscopy can significantly assist in differentiating between clinically similar skin lesions, improving diagnosis and treatment strategies.
Superficial Radiation Therapy (SRT-100) for Hypertrophic Neurodermatitis.
Indian J Dermatol
February 2024
From the Department of Dermatology, Wuhan No. 1 Hospital, Wuhan, China E-mail:
Animal exposure, sensitization, and allergic symptoms in first-year veterinary medicine students.
Allergol Select
March 2024
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany.
Article Synopsis
- The AllergoVet study investigates how long-term exposure to animals affects sensitization and allergic diseases in veterinary medicine students, focusing on their lifetime contact with various animal species.
- Among the 313 participants, sensitization to common allergens was found in 38.4%, with cats, dogs, and horses showing specific sensitizations at lower rates; however, most didn’t report significant allergic symptoms.
- Results indicated no strong links between exposure and sensitization for cats and horses; notably, those with more contact with dogs showed a decrease in dog-specific sensitizations, and farm upbringing was associated with no sensitization.
Clinical and Temporal Characteristics of Malignancy-Associated Prurigo Nodularis: A Systematic Review.
Skinmed
March 2024
Department of Dermatology, Tulane University School of Medicine, New Orleans, LA.
Scleroderma Associated With Organising Pneumonia and Polyarthritis: A Report of a Rare Case.
Cureus
January 2024
Pulmonary and Critical Care Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- - Cryptogenic organising pneumonia (COP) is a type of lung disease caused by unknown irritants, particularly damaging type II pneumocytes and the alveolar basement membrane.
- - Systemic sclerosis (SSc) is an autoimmune disease that can lead to severe lung complications like pulmonary hypertension and interstitial lung disease (ILD), where COP can occur alongside other symptoms.
- - This report discusses cases of scleroderma and inflammatory polyarthritis that are associated with COP, noting that it's rare for OP to be the first sign of arthritis, and more research is needed to understand its clinical features.
Vulvar dermatoses and depression: A systematic review of vulvar lichen sclerosus, lichen planus, and lichen simplex chronicus.
JAAD Int
June 2024
Department of Dermatology, University of California Irvine, Irvine, California.