2 results match your criteria: "Libin Cardiovascular Institute of Calgary[Affiliation]"
Genetic Association Study in Multigenerational Kindreds With Vasovagal Syncope: Evidence for Involvement of Sex-Specific Serotonin Signaling.
Circ Arrhythm Electrophysiol
January 2019
Libin Cardiovascular Institute of Calgary, Alberta, Canada (R.S., M.S.R., D.R., K.M., C.M., J.J., B.G.).
Background: Several studies suggest that vasovagal syncope has a genetic origin, but this is unclear. We assessed whether plausible gene variants associate with vasovagal syncope.
Methods: We studied 160 subjects in 9 kindreds comprising 82 fainters and 78 controls.
Norepinephrine transport inhibition for treatment of vasovagal syncope.
J Cardiovasc Electrophysiol
July 2013
Libin Cardiovascular Institute of Calgary, Calgary, Alberta, Canada.
Introduction: Norepinephrine transporter inhibitors, such as sibutramine, have been shown to prevent vasovagal syncope induced by tilt testing in healthy volunteers. As a test of concept we assessed whether sibutramine prevents fainting in highly symptomatic VVS patients.
Methods And Results: This was an open label, dose-ranging protocol of sibutramine 10, 15, and 20 mg daily for ≥4 weeks per dose, with progression dictated by response and tolerance.