1,725 results match your criteria: "Liaquat University of Medical & Health Sciences LUMHS[Affiliation]"

Background: One of the most prevalent causes of morbidity and death is cerebrovascular disease in the US. The manifestations and pathophysiology of cerebrovascular disease are significantly impacted by ageing and determine the quality of one's late life. However, contemporary mortality trends in cerebrovascular disease and comparison to older adults of different gender, race, and geographic disparities have not been fully examined.

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  • Beta blockers (BB) and calcium channel blockers (CCB) are effective treatments for angina, and this study compares their effectiveness and safety for patients over one year.
  • The study found that most patients were using CCB (54.4%) compared to BB (36.36%), with a small percentage on a combination of both (9.8%), but CCB showed better stability in heart rate and blood pressure.
  • The results indicated that while both BB and CCB improved angina symptoms (with 83 out of 110 patients reporting benefits), CCB was associated with fewer adverse drug reactions (ADRs) than BB, suggesting it may be a safer long-term option.
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Objective: This study aimed to evaluate the accuracy and reproducibility of information provided by ChatGPT, in response to frequently asked questions about radiofrequency ablation (RFA) for varicose veins.

Methods: This cross-sectional study was conducted at The Aga Khan University Hospital, Karachi, Pakistan. A set of 18 frequently asked questions regarding RFA for varicose veins were compiled from credible online sources and presented to ChatGPT twice, separately, using the new chat option.

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  • * A case study details a 75-year-old Hispanic male with relapsed/refractory Philadelphia-positive B-cell ALL, who was treated with multiple TKIs and chemotherapy, culminating in a novel combination of ponatinib and asciminib before and after brexu-cel therapy.
  • * This combination of ponatinib and asciminib proved to be effective, controlling the disease for 2 months before brexu
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Background: Metformin plays a major part in the treatment of polycystic ovarian syndrome .Trials are being conducted to compare the effectiveness of combination of metformin with cabergoline in the treatment of hyperprolactinemia and polycystic ovarian syndrome.

Objectives: The purpose of this study is to compare the effectiveness of metformin monotherapy and combination therapy with cabergoline versus metformin for the management of polycystic ovarian syndrome with hyperprolactinemia.

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Smoking has emerged as a predominant risk factor for coronary artery disease (CAD) in India, contributing significantly to the country's rising cardiovascular morbidity and mortality rates. The adverse effects of tobacco on cardiovascular health are well-documented, exacerbating a public health challenge in a nation with a high prevalence of smoking. Therefore, it is of interest to analyse the impact of smoking on the incidence and progression of coronary artery disease among the Indian population, emphasizing the need for targeted public health interventions to mitigate this risk factor.

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  • Cardiovascular diseases (CVDs) affect the heart and blood vessels, and identifying high-risk individuals is crucial for prevention efforts.
  • A year-long study at a Tertiary Care Hospital analyzed the lipid profiles and blood pressure of obese and non-obese participants aged 30-60, revealing higher LDL cholesterol and lower HDL cholesterol in the obese group.
  • Results indicate that obesity negatively impacts lipid metabolism and blood pressure, emphasizing the importance of assessing these factors for better cardiovascular risk evaluation.
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  • Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
  • In 2021, strokes caused about 7.3 million deaths and were a major cause of health problems, especially in specific regions like Southeast Asia and Oceania.
  • There are differences in stroke risks based on where people live and their age, and some areas actually saw more strokes happening since 2015.
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Non-technical skills for neurosurgeons: An international survey.

Brain Spine

August 2024

Department of Neurosurgery, Fondazione I.R.C.C.S. Istituto Neurologico "C. Besta", Milano, Italy.

Article Synopsis
  • Neurosurgery requires not only technical skills but also non-technical skills (NTSs) to achieve mastery, highlighting the importance of both in surgical practice.
  • An international survey of 372 neurosurgeons indicates that qualities like attention to detail, humility, and self-awareness are vital for surgical precision and effective teamwork.
  • The study advocates for integrated training that includes simulations and mentorship to enhance NTSs, while also stressing the need for research aimed at improving educational methods, especially in regions with unequal access to neurosurgical care.
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COVID-19 patients with already existing chronic medical conditions are more likely to develop severe complications and, ultimately, a higher risk of mortality. This study analyzes the impacts of pre-existing chronic illnesses such as diabetes (DM), hypertension, and cardiovascular diseases (CVDs) on COVID-19 cases by using radiological chest imaging. The data of laboratory-confirmed COVID-19-infected hospitalized patients were analyzed from March 2020 to December 2020.

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Introduction: Iron deficiency anemia (IDA) is the most prevalent diet-related disorder and mainly affects women and children. To determine the trend of anemia incidence in Pakistan, a current review was carried out. This review aimed to estimate the prevalence of anemia among pregnant women and adult/adolescent nonpregnant women in Pakistan and to provide a 15-year trend analysis.

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  • The ampulla of Vater is a critical site in the duodenal wall where pancreatic and biliary ducts meet, often linked to tumors known as ampullary adenocarcinomas.
  • A study analyzed 188 cases to compare intra-ampullary and periampullary carcinomas in terms of pathology and survival, revealing that most tumors were found in males around 55 years old, with a predilection for the pancreatobiliary subtype.
  • Results indicated that intra-ampullary carcinomas had worse outcomes, showing more extensive invasion and lower median survival rates (46 months) compared to periampullary carcinomas (53.5 months).
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  • Colorectal cancer (CRC) accounts for about 10% of global cancer cases and deaths; AI-supported methods are being considered to assist pathologists with the increasing workload of examining lymph nodes post-surgery.
  • The study involved analyzing digital images of lymph nodes from 165 CRC cases, using AI software to detect tumor deposits, and it showed high accuracy with 84% true positives and 88.5% true negatives.
  • Results indicated a sensitivity of 89% and specificity of 83.1%, suggesting AI could support pathologists, and further research with larger samples is recommended to validate these findings.
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  • Intravenous thrombolysis (IVT) is a standard treatment for acute ischemic stroke, but current guidelines advise against its use in patients on Direct Oral Anticoagulants (DOACs) taken within 48 hours prior due to the risk of serious bleeding.
  • A study analyzed four research articles involving over 238,000 stroke patients and found that patients who used DOACs had a lower chance of developing symptomatic intracranial hemorrhage (sICH) and a greater chance of being functionally independent after 90 days compared to those who didn’t.
  • The results suggest that IVT is a safe treatment option for acute ischemic stroke in patients who recently took DOAC
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Background: Leadership is a critical competency for medical professionals, yet it is often neglected in medical training. For ObGyn residents, leadership training is particularly crucial as it significantly impacts both maternal and newborn outcomes, as well as the operational efficiency of healthcare teams. The main objective of this study was to assess the perceptions of obstetrics and gynecology residents who served as group leaders in the emergency team at the Department of Gynecology, Ward 3, Dr.

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  • The study presents a case series of 49 patients who underwent minimally invasive tubular surgery for spinal schwannomas and neurofibromas, highlighting the procedure’s effectiveness and safety.
  • The authors review existing literature on similar cases, providing insights into surgical outcomes and patient recovery following the procedure.
  • The article emphasizes the potential benefits of minimally invasive techniques over traditional surgeries, such as reduced recovery time and lower complication rates.
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Infertility, which affects 8%-12% of couples worldwide and 21.9% of couples in Pakistan in particular, is a major reproductive health issue. In vitro fertilization (IVF) has emerged as a prevalent therapeutic intervention.

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  • * There is an increasing link between CD and cardiovascular diseases (CVDs) like atherosclerosis and arrhythmia, attributed to factors like chronic inflammation and nutrient deficiencies.
  • * The article reviews how CD may lead to different CVD outcomes, analyzing existing studies that show both positive and negative effects of CD on cardiovascular health.
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  • Transcatheter aortic valve implantation (TAVI) is often favored over surgical aortic valve replacement (SAVR) for patients with severe aortic stenosis and significant surgical risks, especially among obese individuals.
  • A systematic review of 5 studies involving 16,161 patients found that TAVI is associated with lower in-hospital mortality, fewer cases of acute kidney injury, and shorter hospital stays compared to SAVR.
  • However, TAVI had higher rates of permanent pacemaker implantation and major vascular complications, indicating that while TAVI is generally beneficial for obese patients, a tailored approach to treatment is essential for optimal results.
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Background: Del Nido cardioplegia (DNC) has extensively been used for pediatric population undergoing cardiac surgery. However, its use in adult cardiac surgeries have been limited thus, its benefits are not yet fully known. This analysis was performed to evaluate the impact of DNC versus any other type of cardioplegia in adult patients who are undergoing cardiac surgery.

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  • Neonatal encephalopathy (NE) is a serious brain condition in newborns that affects how their bodies work, especially their brain and blood sugar levels.
  • Low blood sugar (hypoglycemia) and high blood sugar (hyperglycemia) can make NE worse and are linked to serious problems like death and disabilities.
  • Doctors use cooling treatment (therapeutic hypothermia) to help protect the brain, and new methods like checking blood sugar levels often and using glucagon (a medication) can help manage blood sugar and improve health for these babies.
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