5 results match your criteria: "Liaquat College of Medicine and Dentistry and Darul Sehat Hospital[Affiliation]"
Article Synopsis
- The study aimed to understand the genetic factors of prostate cancer by analyzing 14 genes linked to cancer susceptibility using Next Generation Sequencing (NGS).
- Key findings revealed pathogenic mutations in genes like BRCA1, BRCA2, and TP53, along with benign variations, highlighting their differing roles in cancer progression.
- Functional tests showed that mutations in BRCA1 and BRCA2 were linked to lower expression levels and increased sensitivity to certain chemotherapy drugs, while mutations in TP53 did not notably affect drug response.
Unlocking the diagnostic, prognostic roles, and immune implications of BAX gene expression in pan-cancer analysis.
Am J Transl Res
January 2024
Department of Biotechnology, Institute of Biochemistry, Biotechnology and Bioinformatics, The Islamia University of Bahawalpur Bahawalpur 63100, Pakistan.
Objectives: Cancer, a formidable disease, continues to challenge our understanding and therapeutic approaches. This study delves into the pan-cancer analysis of BCL2 Associated X (BAX) gene expression, seeking to unravel its significance in cancer development, prognosis, and potential therapeutic strategies.
Methods: A combination of bioinformatics and molecular experiments.
Ovarian reserve parameters and response to controlled ovarian stimulation in infertile patients.
Pak J Med Sci
January 2019
Sarim Muhammad Yousuf, Ziauddin Medical University (3 Year MBBS).
Objective: To determine the ovarian reserve parameters in patients presenting for IVF and intracytoplasmic sperm injection (ICSI) treatment and its association with the number of follicles retrieved and number of oocyte retrieved and fertilized.
Methods: A retrospective cross sectional study was conducted at Australian Concept Infertility Medical Centre from January 2017 to August 2017. Around 120 couples presenting to infertility clinics selected for IVF and ICSI with Females (25-45) had their FSH, AMH and AFC done.
Pattern of electrolyte imbalance in Type 2 diabetes patients: Experience from a tertiary care hospital.
Pak J Med Sci
January 2019
Dr. Mohammad Hassan Siddique, MBBS. House Officer, Liaquat College of Medicine and Dentistry and Darul Sehat Hospital, Karachi, Pakistan.
Objective: To determine frequency of electrolyte imbalance including sodium, chloride, potassium and magnesium levels present in patients with uncontrolled diabetes at a tertiary care hospital in Karachi.
Methods: This was a descriptive cross sectional study conducted at Medicine Department, Darul Sehat Hospital, Karachi, Pakistan from March 2017 to October 2017. A total of one hundred and eighty one admitted and OPD patients with uncontrolled diabetes (HbA1c more than 7%) were included and their demographics, comorbidities, microvascular complications, drug history, fasting and random blood glucose and serum electrolyte levels were recorded.
Osteomalacia in a Case of Adult-Onset Bartter Syndrome.
Eur J Case Rep Intern Med
March 2018
Internal Medicine, Liaquat College of Medicine and Dentistry and Darul Sehat Hospital, Karachi, Pakistan.
Unlabelled: Bartter syndrome is a rare heterogeneous disease characterised by a deficiency in sodium and chloride absorption. Gain-of-function mutations in the CASR gene have been described in some patients with Bartter syndrome associated with hypocalcaemia and hypercalciuria. We describe a case of adult-onset Bartter syndrome with hypocalcaemia severe enough to cause osteomalacia.
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