4,298 results match your criteria: "Leydig Cell Tumors"

Testicular tumors are the most common malignancy of young men and tumors affecting the testis are caused by somatic mutations in germ or germ-like cells. The PI3K pathway is constitutively activated in about one third of testicular cancers. To investigate the role of the PI3K pathway in transforming stem-like cells in the testis, we investigated tumors derived from mice with post-natal, constitutive activation of PI3K signaling and homozygous deletion of tumor suppressor Pten, targeted to nestin expressing cells.

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  • The study discusses two rare cases of postmenopausal women experiencing rapid virilization and high testosterone levels, despite negative imaging results for ovarian masses.
  • Both patients underwent hormone profiling and inconclusive imaging, leading to a suspicion of ovarian tumors, prompting surgical intervention through laparoscopic oophorectomy.
  • Histological examination after surgery confirmed Leydig cell tumors in one patient and thecoma in the other, with testosterone levels normalizing and symptoms improving post-surgery, emphasizing the need for thorough evaluation of androgen excess in postmenopausal women.
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  • This study analyzes 37 ovarian Sertoli-Leydig cell tumors (SLCT) with a focus on their morphology, immunohistochemistry, and molecular features, categorizing them into well, moderately, and poorly differentiated tumors.
  • High levels of sex cord markers were found, along with variable expression of other markers, and notable mutations like DICER1 (54.5%) and FOXL2 (6%) were identified, suggesting important diagnostic and predictive implications.
  • Differences in mRNA expression profiles between DICER1 and non-DICER1 tumors highlight the distinct molecular characteristics of SLCTs, indicating that well-differentiated tumors could represent a unique subtype apart from the others.
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  • * The tumors included various types, such as aortic and carotid body PGLs, thyroid cancer, and other growths, with one aortic body tumor showing malignant traits.
  • * No genetic mutations were found in the SDHD gene subunits analyzed, indicating that other genetic factors may contribute to tumor development, prompting further research in this area.
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Leydig cell tumors (LCT) are rare neoplasms that represent less than 0.1% of all ovarian tumors. This tumor usually presents with signs and symptoms of excess androgen levels.

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Cordycepin Activates Autophagy to Suppress FGF9-induced TM3 Mouse Leydig Progenitor Cell Proliferation.

Cancer Genomics Proteomics

October 2024

Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.

Background/aim: Fibroblast growth factor 9 (FGF9) is a member of the human FGF family known for its pivotal roles in various biological processes, such as cell proliferation, tissue repair, and male sex determination including testis formation. Cordycepin, a bioactive compound found in Cordyceps sinensis, exhibits potent antitumor effects by triggering apoptosis and/or autophagy pathways. Our research has unveiled that FGF9 promotes proliferation and tumorigenesis in MA-10 mouse Leydig tumor cells, as the phenomena are effectively countered by cordycepin through apoptosis induction.

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Heat shock response is characterized by the induction of heat shock proteins (HSPs) or molecular chaperones that maintain protein homeostasis. Heat shock transcription factor 1 (HSF1) plays a central role in heat shock response in mammalian cells. To investigate the impact of the heat shock response mechanism on steroidogenesis, we generated MA-10 mouse Leydig tumor cells deficient in HSF1 using CRISPR-Cas9 genome editing.

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Anti-Inflammatory effect of INSL-3 on experimental arthritis model and LPS-induced macrophage cell line.

Int Immunopharmacol

December 2024

Department of Histology and Embryology, Faculty of Medicine, Cukurova University, Adana, Turkey. Electronic address:

Rheumatoid arthritis (RA) is a multifactorial autoimmune disease that affects the joints of approximately 1 % of the population worldwide and is seen 2-4 times less in males. INSL3 is a gender-specific peptide hormone produced much higher in males than in females and may have an anti-inflammatory role in RA. So, in this study, it was aimed to determine the possible anti-inflammatory effect and dose of insulin-like factor-3(INSL3) in an experimental Complete Freund's adjuvant(CFA)-induced RA male rat model and lipopolysaccharide(LPS)-induced macrophage cell line and compare it with prednisolone therapy.

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  • * Conventional ultrasound is essential for evaluating scrotal conditions, while Contrast-Enhanced Ultrasound (CEUS) helps differentiate between benign and malignant masses.
  • * New advancements like Super Resolution CEUS Micro-Vascular Imaging and Time of Arrival mapping enhance the clarity of microvascular structures and improve diagnostic accuracy in testicular pathologies.
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  • The study assesses the effectiveness of a dual checkpoint inhibition therapy (ipilimumab and nivolumab) on advanced non-epithelial ovarian cancers (NEOCs) in patients who have no other effective treatments available.
  • In a clinical trial involving 17 patients, the therapy showed a 25% overall response rate in those with granulosa cell tumors, with some patients experiencing significant progression-free survival and overall survival benefits.
  • However, the therapy had serious side effects, leading to treatment discontinuation in 18% of participants and no positive responses noted in carcinosarcoma cases.
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DICER1-Related Tumor Predisposition: Identification of At-risk Individuals and Recommended Surveillance Strategies.

Clin Cancer Res

December 2024

International Pleuropulmonary Blastoma/DICER1 Registry, Children's Minnesota, Minneapolis, Minnesota.

Article Synopsis
  • DICER1-related tumor predisposition is linked to an increased risk of both benign and malignant tumors, prompting the need for guidelines on testing and imaging for affected individuals.
  • A study enrolled participants from various registries and identified 713 individuals with germline DICER1 variants, leading to the diagnosis of multiple cases of pleuropulmonary blastoma (PPB) and ovarian Sertoli-Leydig cell tumors (SLCT).
  • The findings suggest that early imaging and surveillance can help detect PPB and may lower the risk of advanced disease, leading to recommendations for earlier ovarian surveillance beginning at the detection of DICER1 variants.
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  • - Diabetes can cause testicular damage and infertility, which this study targets using regenerative therapy through Wharton's jelly mesenchymal stem cells (WJMSCs) and their trophic factors.
  • - The study involved 56 male rats divided into control and diabetic groups, administering early and late treatments with WJMSCs-CM or insulin, monitoring their blood glucose, reproductive hormones, and sperm parameters.
  • - Results indicated that WJMSCs-CM treatment improved sperm quality, hormonal levels, and reduced oxidative stress and inflammation in diabetic rats, suggesting it may help reverse diabetes-related testicular damage.
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  • A woman in her 30s experienced primary infertility and secondary amenorrhoea, with signs of virilisation and a solid mass found on her right ovary, leading to concerns about an ovarian tumor.
  • Tests indicated the likely presence of an androgen-producing tumor called a Sertoli-Leydig cell tumour (SLCT), which was confirmed through histopathology after a fertility-sparing surgery.
  • Following the surgery, the patient’s testosterone levels dropped significantly, and her menstrual cycle resumed, highlighting the importance of recognizing SLCTs in similar cases and considering fertility-preserving options in young women with such conditions.
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An ovarian Sertoli-Leydig cell tumor is a rare type of sex cord-stromal tumor of the ovary. Typically, it presents as abdominal pain or androgenic manifestations in women in the second to third decade of life. While cases of ovarian Sertoli-Leydig cell tumor associated with increased levels of alpha-fetoprotein are rare, they are reported to be the most common alpha-fetoprotein-producing ovarian non-germ cell tumor.

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Regulation of corticosteroid-binding globulin release in murine leydig tumor cell line mLTC-1 by luteinizing hormone and interleukin-6.

Arch Biochem Biophys

November 2024

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, China. Electronic address:

Exogenous assaults interfere with homeostatic processes in the body by inducing stress responses. Corticosteroid-binding globulin (CBG) binds to stress hormone glucocorticoids to transport and dynamically control their availability to target tissues. In our previous study, we confirmed that CBG is locally produced by Leydig cells in the testes.

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Pure intertubular seminoma (PITS) of the testis: A multi-institutional cohort of a rare growth pattern of seminoma.

Hum Pathol

November 2024

Department of Pathology and Laboratory Medicine, CORE Diagnostics, India. Electronic address:

Article Synopsis
  • Pure intertubular seminoma (PITS) is a rare type of testicular cancer where seminoma cells are found in testicular interstitium without forming a noticeable mass or diffuse growth, leading to challenges in diagnosis.
  • This condition often goes unnoticed and is usually diagnosed incidentally during evaluations for testicular pain, infertility, or other issues, with only a minority of cases presenting with metastasis.
  • A study involving 15 patients revealed that the average age at presentation was 29, and common symptoms included undescended testis, testicular pain, and infertility, while most patients had normal serum markers and no visible tumors at the time of diagnosis.
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Characteristics and prognostic implications of a cohort of 50 Sertoli-Leydig cell tumors at a single center.

Int J Gynaecol Obstet

September 2024

National Clinical Research Center for Obstetric and Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Article Synopsis
  • - The study analyzed 50 cases of Sertoli-Leydig cell tumors (SLCTs) to understand their clinical features, treatment methods, and outcomes, finding that the majority of patients were under 45 years old.
  • - Results showed that 90% of patients achieved clinical remission, with the prognosis being generally favorable for early-stage tumors, while advanced and aggressive variants experienced worse outcomes.
  • - The research suggests that fertility-sparing surgery is a viable treatment option for patients with early-stage SLCTs, with some patients successfully giving birth to healthy babies post-treatment.
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Iron is a key element in spermatogenesis; its metabolic pathway in the testis is strictly regulated. Alterations in iron metabolism are linked to various diseases, including cancer, and changes in iron metabolism-related proteins have been observed in multiple human, mouse and canine tumors. There is limited knowledge about iron metabolism in canine non-neoplastic and neoplastic testes.

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Background: Testicular germ cell tumors (TGCTs), derived from primordial germ cells, are rare malignancies with high curative potential. However, the emergence of new evidence indicating that 15% of patients experience tumor progression, leading to death, underscores the need for innovative therapeutics.

Objectives: This review aimed to explore the immune status in maintaining testicular health and the immune-related aspects of malignancy.

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Giant Sertoli-Leydig cell tumor of ovary in a 12-year-old girl: An unusual case report.

Asian J Surg

September 2024

School of Clinical Medicine, Southwest Medical University, Luzhou, Sichuan Province, 646000, PR China; Department of Emergency, Zigong First People's Hospital, Zigong, Sichuan Province, 643000, PR China. Electronic address:

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Sidonia and Nicu de Barcsy: a famous mother with post-partum hirsutism after giving birth to a famous son with idiopathic short stature.

Endocrinol Diabetes Metab Case Rep

July 2024

Department of Internal Medicine, Sector of Endocrinology, Erasmus MC, Dr. Molewaterplein40, Rotterdam, the Netherlands.

Summary: At the end of the 19th century, an 18-year-old lady gave birth to a well-proportioned, though very small, son. After delivery, the mother developed a full-grown beard, whereas the son always remained of small stature. The mother developed diabetes mellitus and died, aged 59, from a complicated severe cold.

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