183 results match your criteria: "Leuven Biostatistics and Statistical Bioinformatics Centre[Affiliation]"

Continuous donor-recipient age matching in the Eurotransplant region: outcomes, parameters and prediction.

Am J Transplant

January 2025

Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium. Electronic address:

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Background: Cerebral visual impairment (CVI) can negatively affect a child's functioning, emphasising the need for interventions to improve visual perception (VP), potentially translating into improved health-related quality of life (HRQOL).

Aims: Assessing the effectiveness of an adaptive individualised game-based rehabilitation, iVision, on VP, visual function, functional vision, and HRQOL.

Methods And Procedures: Seventy-three children with CVI (3-12 performance age) were randomised into the adaptive individualised or the non-adaptive non-individualised group (3 sessions/week; 12 weeks).

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Late intervention for type II endoleak is not determined by early sac diameter or volume changes after EVAR.

Radiol Oncol

December 2024

Department of Radiology, University Hospitals KU Leuven, Leuven, Belgium and Department of Imaging & Pathology, KU Leuven, Leuven, Belgium.

Background: To compare the diagnostic accuracy and predictive value of aneurysm sac volume measurement versus maximum diameter measurement of abdominal aortic aneurysm sac after endovascular aneurysm repair (EVAR) in patients with type II endoleak.

Patients And Methods: Retrospective study on a cohort of 103 patients who presented with a type II endoleak after EVAR for infrarenal abdominal aortic aneurysm. Maximum diameter and volumetric measurements were calculated on computed tomography follow-up scans at 3 months and 1 year after index surgery.

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An observational cohort study of kidney function evolution following increased BK viral replication.

Kidney Int

January 2025

Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium. Electronic address:

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Background: Over the past four years, the COVID-19 pandemic has exerted a profound impact on public health, including on mortality trends. This study investigates mortality patterns in Belgium by examining all-cause mortality, excess mortality, and cause-specific mortality.

Methods: We retrieved all-cause mortality data from January 1, 2009, to December 31, 2022, stratified by age group and sex.

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Article Synopsis
  • This study investigates how human serum albumin (HSA) levels affect drug distribution in neonates, aiming to establish trends in HSA over time and create a predictive model for HSA concentrations.
  • A total of 848 neonates were analyzed, revealing that HSA concentrations increase with postnatal age and gestational age, and several factors like birth weight and bilirubin levels significantly influence these concentrations.
  • The resulting prediction model demonstrated a high performance with an accuracy of 76.3%, providing valuable HSA centiles and insights that could improve clinical care and pharmacotherapy for neonatal patients.
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Purpose: To retrospectively analyze the technical and long-term clinical outcome of angioplasty and stenting using the Venovo™ venous stent for the treatment of malignant and benign superior vena cava (SVC) occlusive disease.

Materials And Methods: Consecutive patients treated with the Venovo™ venous stent for SVC occlusive disease were included. SVC obstruction symptoms were classified according to the Kishi score.

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A competing risks model to estimate the risk of graft failure and patient death after kidney transplantation using continuous donor-recipient age combinations.

Am J Transplant

February 2025

Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Graft failure and recipient death with functioning graft are important competing outcomes after kidney transplantation. Risk prediction models typically censor for the competing outcome thereby overestimating the cumulative incidence. The magnitude of this overestimation is not well described in real-world transplant data.

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Probable antibody-mediated rejection in kidney transplantation is a rare and challenging phenotype to define: Findings from a single-center study.

Am J Transplant

January 2025

Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium. Electronic address:

The Banff 2022 consensus introduced probable antibody-mediated rejection (AMR), characterized by mild AMR histologic features and human leukocyte antigen (HLA) donor-specific antibody (DSA) positivity. In a single-center observational cohort study of 1891 kidney transplant recipients transplanted between 2004 and 2021, 566 kidney biopsies were performed in 178 individual HLA-DSA-positive transplants. Evaluated at time of the first HLA-DSA-positive biopsy of each transplant (N = 178), 84 of the 178 (47.

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An observational cohort study examined the change point of kidney function stabilization in the initial period after transplantation.

Kidney Int

September 2024

Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium. Electronic address:

Baseline kidney function following kidney transplantation is often used in research and clinical decision-making yet is not well defined. Here, a method to determine baseline function was proposed and validated on three single-center retrospective cohorts consisting of 922 patients from Belgium (main cohort) and two validation cohorts of 987 patients from the Netherlands and 519 patients from Germany. For each transplant, a segmented regression model was fitted on the estimated glomerular filtration rate (eGFR) evolution during the first-year post-transplantation.

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Article Synopsis
  • The study investigates the impact of high-dose vitamin D supplementation on melanoma relapse in patients who have had curatively resected cutaneous melanoma (CM).* -
  • A total of 436 patients were randomly assigned to either a vitamin D treatment group, receiving 100,000 IU monthly, or a placebo group, with follow-up lasting up to 116 months.* -
  • Results showed that while vitamin D supplementation significantly increased serum levels, it did not noticeably improve relapse-free survival or reduce melanoma-related deaths compared to the placebo group.*
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Wild boar (), an abundant species across Europe, is often subjected to management in agro-ecosystems in order to control population size, or to scare them away from agricultural fields to safeguard crop yields. Wild boar management can benefit from a better understanding on changes in its space use across the diel cycle (, diel space use) in relation to variable hunting pressures or other factors. Here, we estimate wild boar diel space use in an agro-ecosystem in central Belgium during four consecutive "growing seasons" (, April-September).

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Geospatial patterns of excess mortality in Belgium: Insights from the first year of the COVID-19 pandemic.

Spat Spatiotemporal Epidemiol

June 2024

I-BioStat, Data Science Institute, Hasselt University, 3500 Hasselt, Belgium; I-BioStat, Leuven Biostatistics and Statistical Bioinformatics Centre, KU Leuven, 3000 Leuven, Belgium.

Objectives: Belgium experienced multiple COVID-19 waves that hit various groups in the population, which changed the mortality pattern compared to periods before the pandemic. In this study, we investigated the geographical excess mortality trend in Belgium during the first year of the COVID-19 pandemic.

Methods: We retrieved the number of deaths and population data in 2020 based on gender, age, and municipality of residence, and we made a comparison with the mortality data in 2017-2019 using a spatially discrete model.

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In biomedical studies, continuous and ordinal longitudinal variables are frequently encountered. In many of these studies it is of interest to estimate the effect of one of these longitudinal variables on the other. Time-dependent covariates have, however, several limitations; they can, for example, not be included when the data is not collected at fixed intervals.

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Background: In Flanders, general practitioners (GPs) were among the first ones to collect data regarding COVID-19 cases. Intego is a GPs' morbidity registry in primary care with data collected from the electronic medical records from a sample of general practices. The Intego database contain elaborate information regarding patient characteristics, such as comorbidities.

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Prognostic factors for the development of upper limb dysfunctions after breast cancer: the UPLIFT-BC prospective longitudinal cohort study protocol.

BMJ Open

May 2024

Pain in Motion Research Group, Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussel, Belgium.

Introduction: Upper limb (UL) dysfunctions are highly prevalent in people after breast cancer and have a great impact on performing activities in daily living. To improve care, a more comprehensive understanding of the development and persistence of UL dysfunctions is needed. Therefore, the UPLIFT-BC study will primarily examine the prognostic value of different factors at the body functions and structures, environmental and personal level of the International Classification of Functioning, Disability and Health (ICF) framework at 1-month post-surgery for persisting UL dysfunctions at 6 months after finishing cancer treatment.

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Introduction: Lymphoedema is a chronic condition caused by lymphatic insufficiency. It leads to swelling of the limb/midline region and an increased risk of infection. Lymphoedema is often associated with mental and physical problems limiting quality of life.

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Event centrality is defined by the extent to which a memory of an event has become central to an individual's identity and life story. Previous research predominantly focused on the link between event centrality and trauma-related symptomatology. Nevertheless, it can be argued that the perception of (adverse) events as central to one's self is not exclusive to Posttraumatic Stress Disorder (PTSD).

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Clinical and genetic determinants of vitamin D receptor expression in cutaneous melanoma patients.

Melanoma Res

April 2024

Laboratory of Dermatology, Department of Oncology, KU Leuven, UZ Leuven, Leuven, Belgium.

Article Synopsis
  • Decreased expression of vitamin D receptors (VDR) in melanoma and melanocytic naevi compared to normal skin is observed, revealing a potential link to melanoma characteristics.
  • A study involving 407 melanoma patients analyzed how VDR expression correlated with vitamin D levels, demographic factors, VDR genetic variants, and tumor pathology.
  • Findings showed higher cytoplasmic VDR expression in patients with greater sun exposure and different genetic variants, while lower nuclear VDR expression was associated with tumor characteristics like mitosis and perineural invasion.
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Objectives: This study aimed to explore the internal constructs of the concepts being measured by EQ-5D-5L (a health-related quality of life measure that can produce preference-based utility values) and the 12-item General Health Questionnaire (GHQ-12, a mental well-being measure) and to understand to what extent the items of EQ-5D-5L and GHQ-12 associate with each other.

Methods: We used data from 12 701 respondents participating in a Belgian survey in 2022. Correlation coefficients between GHQ-12 and EQ-5D-5L were calculated at both the aggregate and item levels.

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Introduction: COVID-19 remains a major concern globally. Therefore, it is important to evaluate COVID-19's rapidly changing trends. The fractal dimension has been proposed as a viable method to characterize COVID-19 curves since epidemic data is often subject to considerable heterogeneity.

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Increasing human-wild boar interactions have led to damage to agricultural crops, traffic collisions and disease transmissions. Dividing natural areas in zones with differential hunting pressure is one of the currently adopted management strategies. However, the effectiveness of this approach is under debate.

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We investigated the efficacy and safety of a bilateral anterior quadratus lumborum block in patients undergoing minimally invasive colorectal surgery. This was a two-centre, double-blind, prospective, randomised, placebo-controlled trial including 150 patients undergoing laparoscopic colorectal surgery (left- or right hemicolectomy, sigmoidectomy) who were enrolled in the institutional abdominal enhanced recovery programme. Before induction of anaesthesia, patients received a bilateral anterior quadratus lumborum block in the left and right lateral decubitus position under ultrasound guidance and were allocated randomly to receive 30 ml of ropivacaine 0.

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Study Question: Are cumulative pregnancy rates better if supernumerary embryos are vitrified on Day 5/6 instead of Day 3?

Summary Answer: The results do not show a significant difference in cumulative pregnancy rates between the Day 3 and Day 5/6 vitrification groups.

What Is Known Already: Pregnancy and live birth rates following IVF or ICSI treatment are higher after extended embryo culture and blastocyst transfer (Day 5/6) compared to cleavage-stage (Day 3) transfer. Cumulative pregnancy rates from one oocyte retrieval (OR) cycle show no significant difference after fresh and frozen embryo transfers, but only one study has used vitrification for the cryopreservation of supernumerary embryos while four studies have used a slow freezing protocol.

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Estimation of changes in abundances and densities is essential for the research, management, and conservation of animal populations. Recently, technological advances have facilitated the surveillance of animal populations through the adoption of passive sensors, such as camera traps (CT). Several methods, including the random encounter model (REM), have been developed for estimating densities of unmarked populations but require additional information.

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