Design and application of potentiometric sensors for the determination of mefenamic and phenylanthranilic acids.

Characteristics, performance and applications of potentiometric membrane sensors are described for the determination of mefenamic and phenylanthranilic ions. Ion associates of mefenamic, ClO, and phenylanthranilic ions with crystal violet (counter-cation) as ion exchange sites have been used as ionophores in the plasticized one- and two-layer membrane ion-selective electrodes. The LOD is reported to be 8.

Adaptive changes in bodybuilders in conditions of different energy supply modes and intensity of training load regimes using machine and free weight exercises.

Background: The research was aimed at comparing the effect of using two types of training load different in intensity and energy supply. We studied the influence of the proposed load variations (machine and free weight exercises) on long-term adaptation of the body at the stage of specialized basic training in bodybuilding.

Methods: A total of 64 athletes aged 18-20 years were examined.

Di-, tetra-, and perhydropyrrolo[1,2-]imidazoles: The Methods of Synthesis and Some Aspects of Application.

The review summarizes and systematizes the literature data on the synthesis and some aspects of application of pyrrolo[1,2-]imidazoles. Synthetic approaches are grouped according to the degree of saturation of the product pyrroloimidazole ring. The bibliography of the review includes 110 sources over the last 15 years.

Electronic and optical properties of thiogermanate AgGaGeS: theory and experiment.

The electronic and optical properties of an AgGaGeS crystal were studied by first-principles calculations, where the full-potential augmented plane-wave plus local orbital (APW+lo) method was used together with exchange-correlation pseudopotential described by PBE, PBE+, and TB-mBJ+ approaches. To verify the correctness of the present theoretical calculations, we have measured for the AgGaGeS crystal the XPS valence-band spectrum and the X-ray emission bands representing the energy distribution of the electronic states with the biggest contributions in the valence-band region and compared them on a general energy scale with the theoretical results. Such a comparison indicates that, the calculations within the TB-mBJ+ approach reproduce the electron-band structure peculiarities (density of states - DOS) of the AgGaGeS crystal which are in fairly good agreement with the experimental data based on measurements of XPS and appropriate X-ray emission spectra.

The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions.

The current review provides an up-to-date analysis of scientific data on astaxanthin (ASX) sources and experimental studies on its health benefits as a potent antioxidant in the aging process. ASX is a liposoluble carotenoid nutrient and reddish-orange pigment, naturally synthesized by numerous microalgae, yeasts, and bacteria as secondary metabolites. Provides a reddish hue to redfish and shellfish flesh that feed on ASX-producing microorganisms.

STUDY ON SUBJECTIVE WELL-BEING OF DIFFERENT GROUPS OF POPULATION DURING THE 2022 WAR IN UKRAINE.

Objective: The aim: To explore the peculiarities of subjective well-being (psychological well-being, physical health and well-being, relationships) and total well-being of the population during the 2022 war in Ukraine. To analyze the differences in subjective well-being of different population groups during the 2022 war in Ukraine according to the socio-demographic (gender, age, marital status) and socio-professional (social sphere of the work, position) characteristics and place of residence and security (territorial location and security level).

Patients And Methods: Materials and methods: Subjective well-being was studied using the modified BBC Subjective Well-being scale (BBC-SWB).

Media Religiosity and War Coping Strategies of Young People in Ukraine.

The war in Ukraine, in addition to significant human and financial losses, affected the mental health of Ukrainians. This study was carried out within the framework of the population psychological support program in the first month of the war. The objective of the research was to empirically study the interrelationship between media religiosity level and psychological coping given the effects of war.

New 4-thiazolidinone-based molecules Les-2769 and Les-3266 as possible PPARγ modulators.

Development of cancer drug-resistance is still an ongoing problem in the modern anticancer treatment. Therefore, there is a need to search for a new active substance, which may become a potential anticancer agent. 4-Thiazolidinones are well-described substances with cytotoxicity against cancer cells in vitro.

The Role of Retinal Plasticity in the Formation of Irreversible Retinal Deformations in Age-Related Macular Degeneration.

Purpose: To construct a realistic physical model of viscoelastic retinal stretching and, on its basis, derive a universal quantitative criterion of irreversible retinal deformations during age-related macular degeneration.

Methods: In this work, standard methods of nonlinear fracture mechanics of ductile and viscoelastic materials were applied to study the evolution of retinal deformation progress in patients with neovascular age-related macular degeneration in the area of large druses or subretinal or sub-retinal pigment epithelium fluid accumulation. A two-dimensional rhombic model of viscoelastic Kelvin-Feucht primitives was used to reconstruct the parameters included in the approximation of the creep strain growth rate.

Challenges faced by university students during the COVID-19: An international study in five countries during the early phase of the pandemic.

This study focused on the specific challenges of university students in the face of the COVID-19 pandemic and examined similarities and differences in COVID-related concerns and difficulties in functioning in samples of undergraduate students in five countries. A sample of 4306 undergraduate university students (43.8% males, 56.

Novel hybrid pyrrolidinedione-thiazolidinones as potential anticancer agents: Synthesis and biological evaluation.

A series of novel pyrrolidinedione-thiazolidinones was synthesized and subjected to physico-chemical characteristics. They were screened on a panel of cell lines representing different types of cancer, as well as normal human keratynocytes and lymphocytes of peripheral human blood. High antiproliferative activity of 1-(4-chlorophenyl)- and 1-(4-hydroxyphenyl)-3-{5-[(Z,2Z)-2-chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-1-(4-hydroxyphenyl)-pyrrolidine-2,5-diones 2a and 2b was revealed along with satisfactory cytotoxicity characteristics.

Public perceptions of brain health: an international, online cross-sectional survey.

Objectives: To investigate public perspectives on brain health.

Design: Cross-sectional multilanguage online survey.

Setting: Lifebrain posted the survey on its website and social media and shared it with stakeholders.

Effect of C Fullerene on Recovery of Muscle Soleus in Rats after Atrophy Induced by Achillotenotomy.

Biomechanical and biochemical changes in the muscle soleus of rats during imitation of hind limbs unuse were studied in the model of the Achilles tendon rupture (Achillotenotomy). Oral administration of water-soluble C fullerene at a dose of 1 mg/kg was used as a therapeutic agent throughout the experiment. Changes in the force of contraction and the integrated power of the muscle, the time to reach the maximum force response, the mechanics of fatigue processes development, in particular, the transition from dentate to smooth tetanus, as well as the levels of pro- and antioxidant balance in the blood of rats on days 15, 30 and 45 after injury were described.

Direct feedback and social conformity promote behavioral change via mechanisms indexed by centroparietal positivity: Electrophysiological evidence from a role-swapping ultimatum game.

Our behavior is shaped by multiple factors, including direct feedback (seeing the outcomes of our past actions) and social observation (in part, via a drive to conform to other peoples' behaviors). However, it remains unclear how these two processes are linked in the context of behavioral change. This is important to investigate, as behavioral change is associated with distinct neural correlates that reflect specific aspects of processing, such as information integration and rule updating.

PERFORATIVE PERITONITIS IN NEWBORNS: INSTRUMENTAL AND MORPHOLOGICAL EXAMINATION FINDINGS.

Objective: The aim: To study and analyze the results of instrumental diagnostic measures and morphological verification of perforations of abdominal viscera in peritonitis in newborns, their importance in timely diagnosis, as well as to present authors' experience of examining newborns with PP, taking into account the complexity of diagnosis and treatment of these patients.

Patients And Methods: Materials and methods: The study is based on the results of examining 59 newborns with PP of various etiologies. Instrumental methods that were used in the diagnosis of PP and differential diagnosis of other emergencies involved the following: radiological examination (plain abdominal radiography), abdominal and retroperitoneal ultrasound, neurosonography, echocardiography, diagnostic abdominal paracentesis.

Protective Effect of Water-Soluble C Fullerene Nanoparticles on the Ischemia-Reperfusion Injury of the Muscle Soleus in Rats.

The biomechanical parameters of muscle soleus contraction in rats and their blood biochemical indicators after the intramuscular administration of water-soluble C fullerene at doses of 0.5, 1, and 2 mg/kg 1 h before the onset of muscle ischemia were investigated. In particular, changes in the contraction force of the ischemic muscle soleus, the integrated power of the muscle, the time to achieve the maximum force response, the dynamics of fatigue processes, and the parameters of the transition from dentate to smooth tetanus, levels of creatinine, creatine kinase, lactate and lactate dehydrogenase, and parameters of prooxidant-antioxidant balance (thiobarbituric acid reactive substances, hydrogen peroxide, and reduced glutathione and catalase) were analyzed.

Analysis of Biomechanical Parameters of Muscle Soleus Contraction and Blood Biochemical Parameters in Rat with Chronic Glyphosate Intoxication and Therapeutic Use of C Fullerene.

The widespread use of glyphosate as a herbicide in agriculture can lead to the presence of its residues and metabolites in food for human consumption and thus pose a threat to human health. It has been found that glyphosate reduces energy metabolism in the brain, its amount increases in white muscle fibers. At the same time, the effect of chronic use of glyphosate on the dynamic properties of skeletal muscles remains practically unexplored.

Synthesis, Characterization and In Vitro Evaluation of Novel 5-Ene-thiazolo[3,2-][1,2,4]triazole-6(5)-ones as Possible Anticancer Agents.

The present paper is devoted to the search for drug-like molecules with anticancer properties using the thiazolo[3,2-][1,2,4]triazole-6-one scaffold. A series of 24 novel thiazolo-[3,2-][1,2,4]triazole-6-ones with 5-aryl(heteryl)idene- and 5-aminomethylidene-moieties has been synthesized employing three-component and three-stage synthetic protocols. A mixture of -isomers was obtained in solution for the synthesized 5-aminomethylidene-thiazolo[3,2-]-[1,2,4]triazole-6-ones.