Mechanism of action involved in the anxiolytic-like effects of Hibalactone isolated from L.

Background And Aim: Hibalactone (HB) is a lignan related to the anxiolytic-like effects of L. However, there is a need to understand better the mechanism of action of this lignan to support the ethnopharmacological uses of the species. This work aimed to evaluate by and analysis the mechanism of action of HB involved in its anxiolytic-like effects.

Polyphenols-Rich Fraction from Linn. Leaves Attenuates Oxidative and Inflammatory Responses in Neutrophils, Macrophages, and Experimental Lung Injury.

Linn. is a common plant found in the warmest regions of South and Central America and its use in traditional medicine has been reported for the treatment of various illnesses. In the current study, we investigate the antioxidant and anti-inflammatory activities of crude extract and fractions from L.

Cardiovascular risk factors in the elderly: a 10-year follow-up survival analysis.

Aims: Cardiovascular risk factors present a high prevalence and have an impact on the morbimortality of the elderly; however, studies evaluating the impact of cardiovascular risk factors in the elderly have had short follow-up times and have not allowed specific analyses of the effects of these factors in the aged population, including how they affect the survival of the elderly. This study aimed to analyse the survival of elderly individuals living in the community, considering the presence of cardiovascular risk factors.

Methods And Results: A prospective 10-year follow-up was initiated in 2008 with a cohort of 418 elderly people living in a community in Central Brazil.

[Periodontal status of temporarily institutionalized homeless adults and associated factors].

The scope of this cross-sectional study was to describe the periodontal status and its association with sociodemographic, oral-health related behaviors and use of drugs among temporarily institutionalized homeless adults. The data were collected through oral clinical examination and a questionnaire with 102 adults attending the only public institution for this group in Goiânia, Goiás, Brazil. The periodontal condition was measured by the presence of bleeding on probing, dental calculus and pockets, according to the Community Periodontal Index (CPI).

The influence of environmental factors on Clinostomum sp. (Digenea) infection in the fish Cichlasoma paranaense (Kullander, 1983) in Central Brazil.

This study analyzed the parasitism by Clinostomum sp. metacercariae of the neotropical fish Cichlasoma paranaense (Kullander 1983) and environmental variables' influence on their host-parasite relationship in Central Brazil. Fish were collected in five impoundments (I) from three towns: Itauçú (n = 2), Inhumas (n = 1), and Goiânia (n = 2), Goiás State, Brazil.

Acetaminophen treatment evokes anticontractile effects in rat aorta by blocking L-type calcium channels.

Background: Acetaminophen (APAP) is the most widely used analgesic and antipyretic in the world. However, in high or continuous doses, it can cause serious side effects including blood pressure variability and cardiovascular injuries, which are barely explored. This study aimed to evaluate the acute effect of APAP treatment on vascular tone focused on the blocking of Ca channels.

Risk factors for pneumonia in hospitalized older people with femoral fractures: Results from a Brazilian prospective cohort.

Background: Pneumonia is a common complication in older people who are hospitalized to treat different fractures, which increases morbimortality in this population.

Objectives: Estimating the pneumonia incidence density in older people hospitalized to treat femoral fractures and identifying risk factors for this infection.

Methods: Prospective cohort study whose data were collected from a population of older people who were being treated for femoral fractures at a hospital in the central region of Brazil between September 2016 and February 2017.

"A lack of information keeps us from medicine, well-being, harmony…": a mixed method study with plaintiffs requesting medicines in administrative cases.

The need to request public health managers to ensure the right of access to medicines characterizes an administrative case and the method to do so is called the administrative route. This mixed method study aimed to analyze the perceptions of plaintiffs requesting medications by the administrative route about barriers to access medicines in the Brazilian public health sector. Data were gathered through focus groups and questionnaires.

[Dimensions of student violence against the teacher].

Violence against teachers is a global concern and has a negative impact on the development of society. In this context, this study aimed to review definitions of violence against teachers to develop an integrated consensus and conceptual model. A scoping review of the literature was carried out to include articles that could answer the guiding question of the study: "What are the definitions and dimensions of student violence against teachers in teaching?" The studies included in the review, it was identified that violence against the teacher can be defined as a set of actions and situations caused by students in an insidious or chronic way in the workplace and/or through digital medium, mediated by the perception of violence, the copping mechanism of the teacher and the organizational management of the violence.

Epidemiology and prognosis factors in open globe injuries in the Federal District of Brazil.

Objective: To identify the epidemiological profile and prognostic factors of open globe injuries that require emergency surgical treatment.

Design: Retrospective cohort study.

Subjects: Patients with OGI who underwent publicly funded emergency surgical treatment in the Federal District from 2014 to 2018.

Association of Fat Mass with SARC-F in Older Patients Undergoing Haemodialysis.

Background/objectives: An increase in fat mass is accompanied by a loss of muscle mass and function in chronic kidney disease. However, no studies in haemodialysis (HD) patients have investigated the relationship between fat mass and sarcopenia. The primary aim of this study is to assess the prevalence of sarcopenia, while the secondary aim is to verify the association between the fat mass percentage and SARC-F and SARC-F combined with calf circumference (SARC-F+CC) in elderly HD patients.

Effect of the formulation with fipronil and fluazuron on the reproductive biology and ovaries histopathology of Rhipicephalus microplus engorged females.

This study aimed to evaluate the effects of a commercial formulation containing fipronil and fluazuron on the reproductive biology and the morphology of ovaries from Rhipicephalus microplus engorged females. To carry out the study, three calves were artificially infested every 3 days with approximately 5000 larvae. On day 0, the animals were treated with a commercial formulation containing fipronil (1.

Driving and restrictive factors of group practice in community psychosocial care services.

This qualitative research aimed to investigate workers' theoretical conceptions regarding group work and analyze the driving and restrictive factors of group therapeutic practice in Psychosocial Care Centers (CAPS). Sixty-six workers from CAPS and outpatient clinics from the Psychosocial Care Network from twenty-three municipalities in the State of Goiás participated in the study. Data were collected through a structured questionnaire and a group interview audio-recorded and documented with photographs.

Validation study of the use of the HRVCAM software for the evaluation of heart rate and heart rate variability at rest.

Aims: The existing instruments for assessing heart rate (HR) and heart rate variability (HRV) require contact area. This is difficult to obtain from specific groups of patients and from those moving. The aim of this study was to validate the use of the HRVCam software for measuring HR and HRV in healthy adults.

Application of Deconica castanella ligninolytic enzymatic system in the degradation of hexachlorobenzene in soil.

Hexachlorobenzene (HCB) is a pollutant still found in the environment despite being widely banned. Considering that basidiomycetes are useful to degrade a variety of organochlorinated pollutants, we therefore report the influence of HCB on the ligninolytic enzymatic system of Deconica castanella. The inoculum was prepared with sugarcane bagasse and soybean flour and was added in soil with and without HCB (2000 mg kg soil ), 5% emulsion containing soybean oil and Tween 20 at proportion 9:1, v:v; with 70% moisture at 25°C.

No effect of intradialytic neuromuscular electrical stimulation on inflammation and quality of life: a randomized and parallel design clinical trial.

Neuromuscular electrical stimulation (NMES) elicits muscle contraction and has been shown to improvement of quality of life. However, if NMES improvement the quality of life and attenuate the inflammation is not fully understood. Therefore, our aim sought to assess the effects of short-term of intradialytic NMES on inflammation and quality of life in patients with chronic kidney disease patients undergoing hemodialysis.

25OH Vitamin D Is No Associated with Muscle Function Loss in Adults and Elderly Patients Undergoing Hemodialysis.

Objectives: In patients with chronic kidney disease, sarcopenia is associated with dialysis treatment, accelerated protein catabolism, and high energy demand. Thus, this study aimed to assess the association between 25-OH vitamin D concentrations and muscle function in patients undergoing hemodialysis.

Design: A cross-sectional study.

Polymorphism 11482 G>A interacts with dietary intake to modulate anthropometric measures and lipid profile in adults with normal-weight obesity syndrome.

Evidence shows that genetic polymorphisms in perilipin 1 gene () are associated with excessive accumulation of body fat and disturbances in cardiometabolic markers. Therefore, the aim of this study was to verify whether the SNP 11482 G>A (rs894160) interacts with nutrient intake, anthropometric, body composition and cardiometabolic markers in adults with normal-weight obesity (NWO) syndrome. A cross-sectional study was carried out with 116 individuals aged 20-59 years, with normal BMI and high percentage of body fat.

Combination of lipid nanoparticles and iontophoresis for enhanced lopinavir skin permeation: Impact of electric current on lipid dynamics.

Nanostructured lipid carriers (NLC)-loaded with lopinavir (LPV) were developed for its iontophoretic transdermal delivery. Electronic paramagnetic resonance (EPR) spectroscopy of fatty acid spin labels and differential scanning calorimetry (DSC) were applied to investigate the lipid dynamic behavior of NLC before and after the electrical current. In vitro release and permeation studies, with and without anodic and cathodic iontophoresis were also performed.

Effects of Formulation and Manufacturing Process on Drug Release from Solid Self-emulsifying Drug Delivery Systems Prepared by High Shear Mixing.

This study sought to investigate the influence of formulation and process factors of the high shear mixing (HSM) on the properties of solid self-emulsifying drug delivery systems (S-SEDDS) containing the model drug carvedilol (CAR). Firstly, liquid SEDDS (L-SEDDS) were prepared by mixing castor oil with different proportions of surfactant (Solutol or Kolliphor RH40) and cosolvent (Transcutol or PEG400). A miscible L-SEDDS with high drug solubility (124.

Lipid stability of egg and laying performance of Japanese quail feed with extract of guava (Psidium guajava L.).

Two experiments were conducted in order to evaluate the effect of dietary inclusion of guava extract on laying performance and lipid stability of egg of Japanese quails. For the first experiment, 384 Japanese quails with 42 days old were distributed in a completely randomized design with four treatments (0.0; 3.

Publication rate of scientific papers presented at the largest event on breast cancer research in Latin America.

Purpose: Medical congresses allow scientific production to be appropriately disseminated and discussed. However, most of the scientific papers presented at medical congresses do not go on to be published in indexed journals. The present study aimed to determine the publication rate of papers presented at the Brazilian Breast Cancer Symposium (BBCS) and trends associated with publication over that timeframe.

Development and Optimization of Solanum Lycocarpum Polyphenol Oxidase-Based Biosensor and Application towards Paracetamol Detection.

The development biosensing technologies capable of delivering fast and reliable analysis is a growing trend in drug quality control. Considering the emerging use of plant-based polyphenol oxidases (PPO) as biological component of electrochemical biosensors, this work reports the first PPO biosensor and its use in the pharmaceutical analysis of paracetamol in tablet formulations. The biosensor was optimized regarding fruit maturation (immature and mature-ripe), vegetal extract volume to be used in biosensor construction as well as optimal pH of electrochemical cell fluid.