2 results match your criteria: "Lerner Research Institute of Cleveland Clinic Cleveland[Affiliation]"
Comparing and Contrasting the Effects of Condensin II Subunit dCAP-D3 Overexpression and Depletion .
Genetics
October 2018
Department of Inflammation and Immunity, Lerner Research Institute of Cleveland Clinic Cleveland, OH, 44195
Article Synopsis
- The Condensin II complex is crucial for genome organization and gene expression during the cell cycle, with abnormal levels linked to various diseases and particularly elevated in somatic cancers.
- Overexpressing the dCAP-D3 subunit of Condensin II in larval tissues led to harmful effects like the formation of protein aggregates and disrupted mitotic timing, despite differing outcomes based on tissue specificity.
- The research suggests that dCAP-D3's functions may be independent of the Condensin II complex and that changes in its levels can negatively impact both mitosis and gene expression, with potential implications for cancer biology.
Crossing the LINE Toward Genomic Instability: LINE-1 Retrotransposition in Cancer.
Front Chem
January 2016
Department of Cellular and Molecular Medicine, Lerner Research Institute of Cleveland Clinic Cleveland, OH, USA.
Retrotransposons are repetitive DNA sequences that are positioned throughout the human genome. Retrotransposons are capable of copying themselves and mobilizing new copies to novel genomic locations in a process called retrotransposition. While most retrotransposon sequences in the human genome are incomplete and incapable of mobilization, the LINE-1 retrotransposon, which comprises~17% of the human genome, remains active.
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