2,088 results match your criteria: "Lerner College of Medicine of Case Western Reserve University[Affiliation]"

Objective: To identify, group and document the surgical management of idiopathic subglottic stenosis (iSGS) in pregnant women among North American centers with expertise in the treatment of airway stenosis.

Background: Idiopathic subglottic stenosis is a rare airway disease that primarily affects women in their third to fifth decade of life. Symptoms of iSGS often worsen during pregnancy and can present as a threat to optimal maternal and fetal health; however there is a lack of evidence addressing the management of iSGS in pregnancy.

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Palisading Adenocarcinoma.

Head Neck Pathol

August 2024

Pathology and Laboratory Medicine Institute, Cleveland Clinic, 9500 Euclid Avenue L15, Cleveland, OH, 44195, USA.

Palisading adenocarcinoma is a morphologically distinct salivary gland neoplasm that has been recently described with predilection to the sublingual gland. We report our experience with this neoplasm to corroborate and enrich the literature and further clarify its phenotype.

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Article Synopsis
  • The study aimed to create and validate algorithms that can effectively identify cases of diabetic retinopathy (DR) from electronic health records (EHRs) across three different healthcare systems.
  • The algorithms were assessed based on specific criteria for identifying DR cases and diabetes controls, yielding high positive and negative predictive values (PPV and NPV) across the different systems tested.
  • Results showed that while the algorithms performed well overall, there were some variances in their effectiveness, especially when comparing different healthcare systems, highlighting the need for further validation to enhance their reliability.
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Secondary reduction mammaplasty techniques and outcomes: Cleveland Clinic experience.

J Plast Reconstr Aesthet Surg

October 2024

Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA; Department of Plastic Surgery, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Background: Information on optimal techniques and outcomes following secondary reduction mammaplasty remains sparse, with only 280 patient cases reported in the literature to date.

Methods: A total of 7179 medical charts of patients who underwent nononcological breast reduction at the Cleveland Clinic Health System from January 2001 to October 2023 were screened to identify whether the procedure was a secondary reduction. Patient charts were then reviewed to extract demographic, surgical, and outcome data.

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Drug-Induced Intracranial Hypertension: The Adverse Effects of Acne Medications and Topical Retinoids.

J Neuroophthalmol

August 2024

Department of Population and Quantitative Health Sciences (JKS), Cleveland, Ohio; Case Western Reserve University, School of Medicine (JKS, JRR), Cleveland, Ohio; Center for Ophthalmic Bioinformatics (JKS, RPS, KET), Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (RPS, KET), Cleveland Ohio; Cleveland Clinic Cole Eye Institute (RPS, KET, DAC), Cleveland, Ohio; and Cleveland Clinic Martin Hospitals (RPS), Cleveland Clinic Florida, Stuart, Florida.

Article Synopsis
  • Tetracyclines and vitamin A derivatives, commonly used for acne and anti-aging, are linked to drug-induced intracranial hypertension (DIIH), but treatment practices and visual outcomes have not been well studied.
  • This study examined 839 patients diagnosed with IIH, finding that 8.10% developed DIIH, most of whom (83%) were using medication for acne, predominantly females with an average age of about 25.
  • Only 3 patients experienced poor visual outcomes, and they all used vitamin A derivatives; the study emphasizes the need for immediate intervention if headaches or visual changes occur in patients taking DIIH medications.
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Objective: The potential association between diabetic retinopathy (DR) worsening and glucagon-like peptide-1 receptor agonists (GLP-1RA) has affected therapeutic management of diabetic patients but remains controversial. This study compared rates of DR development or progression in patients on GLP-1RA to those on SGLT-2 inhibitors (SGLT-2I).

Design: Retrospective cohort study.

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Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multi organ involvement. One of the most common manifestations is pulmonary disease with a reported prevalence between 5%-90%.

Purpose: Given this wide range of prevalence, there is a need to more closely define types of pulmonary disease in SLE and associated risk factors.

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Background And Aims: hamartoma tumor syndrome (PHTS) confers a high risk of specific cancers and is the most common genetic cause of autism spectrum disorder (ASD). Gastrointestinal (GI) phenotypes in PHTS are poorly characterized in children. Thus, we aimed to characterize the GI and hepatic manifestations in children with PHTS and to investigate genotype-phenotype associations.

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Continuous pulse oximetry (cSpO) monitoring use outside established guidelines is common in children hospitalized with bronchiolitis. We analyzed clinicians' real-time rationale for continuous monitoring in stable children with bronchiolitis not requiring supplemental oxygen. Data for this study were collected as part a multicenter deimplementation trial for cSpO in children hospitalized with bronchiolitis.

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Digoxin is still useful, but is still causing toxicity.

Cleve Clin J Med

August 2024

Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

Digoxin, the oldest known cardiovascular drug, is still used today to treat heart failure and atrial fibrillation. Because it has a narrow therapeutic index and multiple interactions, it frequently causes toxicity with a wide range of symptoms and cardiac arrhythmias. More importantly, elevated serum digoxin levels have been linked to a higher risk of death in patients with heart failure or atrial fibrillation, even without signs or symptoms of toxicity.

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Diabetic retinopathy: Screening, prevention, and treatment.

Cleve Clin J Med

August 2024

Vice President, Chief Medical Officer, Cleveland Clinic Martin Hospitals, Cleveland Clinic Florida, Stuart, FL; Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

Internists are integral in the multidisciplinary approach to diabetic retinopathy, contributing significantly to the management of diabetes and diabetes-related complications. Effective screening processes, timely referrals, and strategic diabetes management are imperative to prevent and mitigate the consequences of diabetic retinopathy. The evolution of treatments for diabetic retinopathy has markedly improved vision outcomes and reduced the burden on patients.

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Recurrent syncope in a 62-year-old man.

Cleve Clin J Med

August 2024

Director, Inpatient Lymphoma Myeloma Service, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH; Associate Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

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Article Synopsis
  • Vision loss is a significant disability in the US, and this study aimed to understand the impact of various ocular diseases, demographic factors like sex and race, on the risk of visual impairment.
  • The analysis utilized data from over 90 million patients, focusing on conditions such as diabetic retinopathy, macular degeneration, and glaucoma, identifying those most at risk based on comorbidities and demographics.
  • Results showed that uveitis combined with retinal vein occlusion posed the highest risk for visual impairment, with Black and Hispanic males experiencing a disproportionate incidence compared to white males.
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Article Synopsis
  • - The study aimed to evaluate the effectiveness of cardiac resynchronization therapy (CRT) in patients with severe heart failure, particularly comparing those with New York Heart Association (NYHA) functional classes III and IV at the time of receiving the therapy.
  • - Using a meta-analysis of data from multiple clinical trials (MIRACLE, MIRACLE-ICD, and COMPANION), researchers found that CRT was associated with a longer time before heart failure hospitalization or death, with no significant difference in outcomes between NYHA III and IV patients.
  • - The analysis, which included data from 2309 patients, used advanced statistical models to assess outcomes and confirmed that associating CRT with improved survival and hospitalization rates was consistent across both functional
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Neurological Outcomes Following Craniotomy for Extracorporeal Membrane Oxygenation-Associated Intracranial Hemorrhage: Case Series and Literature Review.

World Neurosurg

October 2024

Department of Neurological Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA; Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Background: Intracranial hemorrhage (ICH) is a potential complication associated with extracorporeal membrane oxygenation (ECMO), which has been increasingly utilized in recent years. A paucity of data exists describing patient outcomes following invasive neurosurgical interventions in patients receiving ECMO therapy. The purpose of this study was to assess the clinical and functional outcomes in patients who underwent cranial neurosurgery for the management of an ECMO-associated intracranial complication.

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Healthcare educators are exploring ways to integrate Large Language Models (LLMs) into the curriculum. At the same time, they are concerned about the negative impact on students' cognitive development. There is concern that the students will not learn to think and problem-solve by themselves and instead become dependent on LLMs to find answers.

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Retrospective Cohort Study of Sickle Cell Disease and Large Vessel Retinal Vascular Occlusion Risk in a National United States Database.

Ophthalmol Retina

January 2025

Cleveland Clinic Cole Eye Institute, Cleveland, Ohio; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio; Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address:

Objective: To determine if differences exist in the risk of developing large vessel retinal vascular occlusions in patients with sickle cell states.

Design: Retrospective cohort study.

Participants: Patients with sickle cell disease (SCD) or trait evaluated by an ophthalmologist were compared with matched controls without SCD or sickle cell trait (SCT) also evaluated by an ophthalmologist.

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The Role of Patient Satisfaction Scores in Clinical Care and Physician Wellness.

J Allergy Clin Immunol Pract

October 2024

Department of Allergy, Immunology, and Rheumatology, University of Rochester School of Medicine, Rochester, NY; Department of Pediatric Allergy and Immunology, University of Rochester School of Medicine, Rochester, NY.

Patient satisfaction scores have become an integral part of the vocabulary of medical practitioners. Patient satisfaction scores are a domain far ignored, but which have recently gained prominence as patients have demanded a fair share of their own assessments of their medical caregivers. This has created a complex interplay of meeting patients' demands and satisfying their wants and needs, which at times may not completely align with the best possible approach to management and standard of care algorithms.

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Purpose: Achromatopsia (ACHM) is a genetically heterogenous relatively stationary congenital autosomal recessive cone disorder characterized typically by photophobia, low vision, nystagmus, hyperopia, grossly normal retinal appearance, and absent photopic responses by full-field electroretinography. Incomplete forms occur as well. This study investigates the genetic basis of clinically suspected ACHM in the United Arab Emirates.

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Paradoxical keratitis and dermatitis following adalimumab treatment.

J AAPOS

October 2024

Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Ohio; Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, UAE. Electronic address:

Article Synopsis
  • * A case report details a 6-year-old girl developing keratitis and dermatitis after receiving adalimumab for chronic recurrent multifocal osteomyelitis.
  • * The symptoms improved after discontinuing adalimumab and starting topical steroids.
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Article Synopsis
  • - Electrophysiological studies play a crucial role in diagnosing and managing various inflammatory retinal diseases, including conditions like Adamantiades-Behçet disease and birdshot chorioretinopathy.
  • - These studies aid not only in identifying these diseases but also in predicting their progression and evaluating treatment effectiveness.
  • - Regular follow-up with electrophysiological assessments can significantly improve patient care for individuals suffering from these retinal inflammatory conditions.
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