Leptospirosis manifested with severe pulmonary hemorrhagic syndrome successfully treated with veno-venous extracorporeal membrane oxygenation: A case report and literature review.

Rationale: The mortality rate associated with pulmonary hemorrhage induced by leptospirosis is notably high. Available treatment modalities are limited, and their efficacy has not been fully demonstrated. Here, we present the case report of a patient with leptospirosis-induced pulmonary hemorrhagic syndrome.

Burden of leptospirosis in Brazil in the last decade.

To correlate the incidence of leptospirosis with sociodemographic data in the Brazilian Unified Health System from 2011 to 2022. This ecological study used national health and economic secondary data sources. Secondary analyses summarized the scenario of disease-related hospitalizations among federative units.

Triple Co-infection With Salmonella typhi, Leptospira, and Campylobacter coli in a Patient From Guayaquil, Ecuador: Clinical and Diagnostic Challenges.

This case report describes the unusual presentation of a 32-year-old male from Guayaquil, Ecuador, who was diagnosed with a rare triple infection caused by , , and . The patient presented with persistent high fever, severe gastrointestinal symptoms, abdominal pain, and jaundice, following the consumption of street food in a resource-limited area. Important clinical findings included hepatosplenomegaly and elevated liver enzymes, which initially complicated the differential diagnosis.

Sequential pulmonary functions in survivors of leptospirosis pulmonary haemorrhage syndrome: a prospective cohort study.

Background: Leptospirosis, a spirochaete infection, can lead to Leptospirosis Pulmonary Haemorrhage Syndrome (LPHS), which requires intensive care admission and has a high mortality. Although data on short-term outcomes are available, the long-term respiratory sequelae of LPHS survivors are not known. We aimed to identify the post-discharge pulmonary functions and functional limitations in survivors of LPHS.

Uncovering latent infections in kidneys: A novel molecular approach for differential detection.

Leptospirosis, a re-emerging zoonotic disease caused by spp., poses significant global health and veterinary challenges. Long-term colonization of renal tubules by in asymptomatic hosts highlights the need for sensitive detection methods.

Predicting Leptospirosis Using Baseline Laboratory Tests and Geospatial Mapping of Acute Febrile Illness Cases Through Machine Learning-Based Algorithm.

Introduction Leptospirosis is a zoonotic infection caused by bacteria, which is reemerging in various regions and often poses a diagnostic challenge due to its nonspecific symptoms. While most infections are mild, severe cases occur in 5-10% of patients and are associated with high mortality, especially in areas with poor sanitation and urbanization. This study aims to investigate the association of specific parameters with leptospirosis diagnosis using a machine learning model and geographic mapping tools to identify spatial patterns and high-risk areas for the disease.

Surface-Enhanced Raman Spectroscopy (SERS) Substrates Based on Photonic Crystal Embedded Bi-Metallic Nanoparticles for Leptospiral DNA Detection.

Leptospirosis is an acute bacterial febrile disease affecting humans and animals in many tropical and subtropical countries. This work presents an optimization of surface-enhanced Raman spectroscopy (SERS) substrates to probe vibrational spectroscopic detail from deoxyribonucleic acid (DNA). The pathogenic gene of LipL32 was used as a biomarker.

Geographical factors and air raid alarms influence leptospirosis epidemiology in Ukraine (2018-2023).

Leptospirosis, a widespread zoonotic disease caused by spp., affects approximately 1 million people annually and causes about 58,000 deaths worldwide. This study examines the epidemiology of leptospirosis in Ukraine from 2018 to 2023, focusing on the impact of weather and geographical factors on disease transmission.

A Rare Case of Weil's Disease Presenting With Severe Hyperbilirubinemia and Acute Kidney Injury: A Diagnostic Challenge in Urban England.

We present a rare and challenging case of Weil's disease in a patient who was admitted to the Critical Care Unit with a clinical suspicion of the condition. The patient showed a prompt response to treatment before laboratory confirmation was obtained. Leptospirosis, a zoonotic disease, is most commonly found in tropical and temperate regions.

Serovar Australis replaces serovar Copenhageni as the most common cause of canine leptospirosis in New South Wales, Australia.

Highly fatal canine leptospirosis emerged in urban Sydney dogs in 2017, and serovar Copenhageni, against which a registered monovalent vaccine is available, was predominant until 2020. This study was conducted to (1) determine serological characteristics of canine leptospirosis in New South Wales (NSW) between 2021 and 2023; (2) describe the geospatial distribution of leptospirosis; and (3) evaluate if clinicopathological abnormalities and outcome differ between the dominant infecting serovars, Copenhageni versus Australis. Cases were identified through referral or direct veterinarian contact and included if clinical and clinicopathological findings confirmed leptospirosis.

Comparison of clinical and laboratory data between hantavirus infection and leptospirosis: a retrospective case series study in southern Taiwan.

Background: Leptospirosis (LS) and hantavirus (HV) are rodent-borne diseases and share similar clinical manifestations, posing diagnostic challenges.

Methods: This retrospective study compared clinical characteristics, laboratory data, complications and outcomes of 33 LS and nine HV cases in Kaohsiung, Taiwan, from 2006 to 2021.

Results: Both LS and HV diseases had high rates of acute kidney injury (84.

seroprevalence in dogs, cats, and horses in Tennessee, USA.

We estimated the seroprevalence in dogs, cats, and horses from Tennessee, USA, using the microscopic agglutination test (MAT) against 12 serovars. We observed seropositivity in 110 of 374 (29.4%) dogs, 21 of 170 (12.

Urinary leptospiral sphingomyelinases as diagnostic markers of leptospirosis in dengue patients co-infected with leptospirosis.

The study aims to evaluate the diagnostic potential of pathogen-specific leptospiral sphingomyelinases, LipL32, LipL41, and HbpA in human patients with dengue-leptospirosis coinfection. Patients (n-86), upon clinical evaluation, were categorized into Group I (n-37; leptospirosis), Group II (n-39; dengue-leptospirosis coinfection), and Group III (n-10; negative for both dengue and leptospirosis). ELISA identified significant levels of the four leptospiral antigens in the urine of Group I and II, but not in Group III patients.

Evaluation of binding activities of a putative lipoprotein LIC_13355 of Leptospira spp.

Pathogenic Leptospira is the etiological cause of the zoonotic life-threatening infection called leptospirosis. The disease is spread worldwide with higher risk in tropical regions. Although leptospirosis represents a burden to the health of humans and animals, the pathogenic mechanisms of Leptospira infection are yet to be clarified.

Leptospira seroprevalence and associated risk factors among slaughterhouse workers in Western Bahr El Ghazal State, South Sudan.

Background: Leptospirosis is a neglected re-emerging and occupational zoonotic disease worldwide. In Africa, contact with livestock is postulated as a potential source of environmental contamination and a source of human Leptospira exposure, though pathways remain unknown. Recently, we confirmed Leptospira exposure and shedding among slaughtered cattle in Western Bahr El Ghazal.

Infectious disease outbreaks in the wake of natural flood disasters: global patterns and local implications.

Climate change is an urgent global health challenge, with floods becoming increasingly frequent and exacerbating the spread of infectious diseases. With its diverse climates and recurring natural disasters, Latin America is particularly susceptible to outbreaks following floods. These events disrupt ecosystems and create ideal conditions for the spread of waterborne and vector-borne pathogens.

Leucine-rich repeat proteins of that interact to host glycosaminoglycans and integrins.

Pathogenic spirochaetes of the genus are the etiological agents of leptospirosis, a zoonotic infection worldwide. The disease is considered an emerging and re-emerging threat due to global warming, followed by heavy rainfall and flooding when outbreaks of leptospirosis occur. Adhesion to host tissues is mediated by surface/extracellular proteins expressed by pathogens during infection.

Molecular Evidence of Leptospira spp. Infection Among Household Dogs From 15 Municipalities of the Department of Caldas, Colombia.

Introduction: Leptospira spp. is a bacterial genus which includes pathogenic species that causes leptospirosis. Several animal species can harbour, shed and disseminate the bacteria through their urine.

Cellular pathophysiology of Leptospira interrogans infection in canine testicular tissue: role of the TLR4/NF-kB/JNK pathway.

Leptospirosis is a prevalent zoonotic disease in dogs. Although it is known that leptospires are primarily harboured in kidney tissues of dogs, it has been reported that they also infect testicular tissue. Leptospira interrogans causes various lesions in canine testicular tissues; however, the pathogenesis has not been clearly explained.

Herd and animal level seroprevalence and associated risk factors of Leptospira interrogans sensu lato serovar Hardjo in cattle in southwest Ethiopia.

Leptospirosis is a significant zoonotic disease that causes high economic losses in cattle production due to its association with abortions, stillbirths, infertility, and reduced milk yields. However, the epidemiology of bovine leptospirosis in Ethiopia is poorly understood. From October 2020 to October 2021, a cross-sectional study was conducted to investigate the seroprevalence of serovar Hardjo in cattle in southwest Ethiopia, as well as the associated risk factors.

A clinicoepidemiological study of serologically diagnosed acute febrile illness in a teaching hospital, Kolkata.

Introduction: Similar presenting manifestations in early phase and lack of awareness of aetiology of acute febrile illness (AFI) are major challenges in management of AFI.

Material And Methods: This was a retrospective observational cross-sectional study conducted in the Department of Microbiology, NRS Medical College, from 1 July 2022 to 30 June 2023 in serologically diagnosed febrile patients attending the outpatient department or admitted. Clinical and epidemiological data and laboratory parameters were recorded in a pretested structured questionnaire study tool, and collected data were analysed on MS-Excel sheets with various charts and tables.

A label-free DNAzyme-based colorimetric sensor for the detection of Leptospira interrogans.

Leptospirosis is a neglected zoonosis caused by a pathogenic spirochete Leptospira. Diagnosis of leptospirosis in the early stage is difficult and can be easily confused with other infections. The existing detection methods are considered chronophagous and labor-intensive.

An Interesting Case of Wernicke's Encephalopathy in Co-Existence With Tropical Infections: A Case Report.

Wernicke's encephalopathy (WE) is an acute neurological disorder arising from thiamine (vitamin B1) deficiency, characterized by a classic triad of ophthalmoplegia, ataxia, and altered mental status. While it is more common in males, it can occur in various contexts, including pregnancy. Leptospirosis, a zoonotic infection, can co-occur with other illnesses such as scrub typhus.