2,973 results match your criteria: "Leonard Davis Institute of Health Economics.[Affiliation]"

Gender Differences in the Diagnosis of Chronic Obstructive Pulmonary Disease after Spirometry.

medRxiv

July 2024

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: Women are more likely than men to report delays in the diagnosis of chronic obstructive pulmonary disease (COPD), though the etiology of these delays is unknown. We sought to test whether delays in COPD diagnosis persist after the performance of spirometry.

Methods: We used the Optum Labs Data Warehouse to identify patients 18 years of age and older without a prior diagnosis of COPD, with a post-bronchodilator forced expiratory volume in 1 second (FEV) to forced vital capacity (FVC) ratio of less than 0.

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Trapped in Violence: A Life Table Analysis of Firearm Injury and Death Among Adolescent Black Males.

J Adolesc Health

December 2024

Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Purpose: We report the chances of 14-year-old males becoming victims of firearm injury or death before age 25 in Philadelphia, Pennsylvania.

Methods: Using life table methods, we followed 4,501 Black males aged 14 years, and a comparison group of 1,751 White males, over 11 years.

Results: Among 14-year-old Black males, the risk of a nonfatal firearm injury before age 25 was 10.

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Article Synopsis
  • This study focuses on comparing how family members perceive the quality of death in patients who died from cardiovascular disease (CVD) versus cancer.
  • A survey was sent out to family members of deceased CVD patients, with results showing that the quality of death score for CVD patients was lower compared to cancer patients receiving palliative care, but higher than those in general wards.
  • Ultimately, the findings suggest that while the quality of death for CVD patients is generally perceived as lower than for those in palliative care, it does not significantly differ from cancer patients in non-palliative care settings.
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What Do We Mean by Sharing of Patient Data? DaSH: A Data Sharing Hierarchy of Privacy and Ethical Challenges.

Appl Clin Inform

October 2024

Department of Biostatistics (Health Informatics), Bioethics Center, Information Society Project, Solomon Center for Health Law and Policy, Center for Biomedical Data Science, and Program for Biomedical Ethics, Yale University, New Haven, Connecticut, United States.

Background:  Clinical data sharing is common and necessary for patient care, research, public health, and innovation. However, the term "data sharing" is often ambiguous in its many facets and complexities-each of which involves ethical, legal, and social issues. To our knowledge, there is no extant hierarchy of data sharing that assesses these issues.

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Purpose: It is unknown whether Medicaid expansion under the Affordable Care Act (ACA) or state-level policies mandating Medicaid coverage of the routine costs of clinical trial participation have ameliorated longstanding racial and ethnic disparities in cancer clinical trial enrollment.

Methods: We conducted a retrospective, cross-sectional difference-in-differences analysis examining the effect of Medicaid expansion on rates of enrollment for Black or Hispanic nonelderly adults in nonobservational, US cancer clinical trials using data from Medidata's Rave platform for 2012-2019. We examined heterogeneity in this effect on the basis of whether states had pre-existing mandates requiring Medicaid coverage of the routine costs of clinical trial participation.

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Background: Text messaging has emerged as a popular strategy to engage patients after hospital discharge. Little is known about how patients use these programs and what types of needs are addressed through this approach.

Objective: The goal of this study was to describe the types and timing of postdischarge needs identified during a 30-day automated texting program.

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Performance of the open-first repair strategy in type A aortic dissection with mesenteric malperfusion syndrome eligible for delayed repair.

J Thorac Cardiovasc Surg

July 2024

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pa.

Article Synopsis
  • The study examines the efficacy of traditional open-first surgery compared to a nontraditional approach of delayed repair for patients with type A aortic dissection complicated by mesenteric malperfusion syndrome.
  • Out of 1228 patients treated, 77 had mesenteric malperfusion syndrome with an in-hospital mortality rate of 29%, which was lower than the 39% for those undergoing delayed repair.
  • Despite higher early mortality in the mesenteric malperfusion group, 10-year survival rates were similar for both treatment strategies, indicating that the open-first approach may be equally effective or superior to the delayed method.
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Article Synopsis
  • This review discusses how large databases contribute to gynecologic oncology research, highlighting their advantages and limitations.
  • It covers several key databases, including NCDB, SEER, and HCUP, detailing their data, access, and management features.
  • Understanding these databases aids readers and researchers in interpreting findings, evaluating new studies, and advancing impactful research in the field.
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Importance: Most dual-eligible Medicare-Medicaid beneficiaries are enrolled in bifurcated insurance programs that pay for different components of care. Therefore, policymakers are prioritizing expansion of integrated care plans (ICPs) that manage both Medicare and Medicaid benefits and spending.

Objective: To review evidence of the association between ICPs and health care spending, quality, utilization, and patient outcomes among dual-eligible beneficiaries.

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Education, organizational changes, and enforcement challenges of the 2019 flavored tobacco sales restriction in Massachusetts.

Drug Alcohol Depend

September 2024

University of Pennsylvania, Annenberg School for Communication, Philadelphia, PA, United States; University of Pennsylvania, Leonard Davis Institute of Health Economics, Philadelphia, PA, United States; Abramson Cancer Center, Tobacco and Environmental Carcinogenesis Program, Philadelphia, PA, United States. Electronic address:

Article Synopsis
  • - In November 2019, Massachusetts became the first state to restrict the sale of all flavored tobacco products and implemented additional tobacco control policies and insurance coverage for treatment, with implementation occurring between November 2019 and June 2020.
  • - A study was conducted through interviews with public health officials, school personnel, and healthcare providers, highlighting key themes such as the importance of education, organizational changes, and enforcement challenges.
  • - Findings revealed that challenges included pandemic restrictions and industry tactics, while facilitators included effective enforcement, advocacy, and coordination among organizations, providing valuable insights for other states looking to implement similar tobacco control policies.
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Longitudinal outcomes of thoracic endovascular aortic repair for ruptured thoracic aortic aneurysms.

J Thorac Cardiovasc Surg

July 2024

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa; Division of Vascular Surgery and Endovascular Therapy, University of Pennsylvania, Philadelphia, Pa.

Article Synopsis
  • This study investigates long-term outcomes of urgent thoracic endovascular aortic repair (TEVAR) for patients with ruptured thoracic aortic aneurysms (rTAA) compared to intact aneurysms (iTAA).
  • Among 321 patients treated, those with rTAA had lower short-term survival rates and higher incidences of complications, but similar long-term survival rates to iTAA patients if they survived the first 90 days.
  • The findings highlight that while immediate outcomes are worse for rTAA patients, their long-term survival becomes comparable to iTAA patients after a significant early survival period.
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Background: Implementation of new practices in team-based settings requires teams to work together to respond to new demands and changing expectations. However, team constructs and team-based implementation approaches have received little attention in the implementation science literature. This systematic review summarizes empirical research examining associations between teamwork and implementation outcomes when evidence-based practices and other innovations are implemented in healthcare and human service settings.

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Leveraging error-prone algorithm-derived phenotypes: Enhancing association studies for risk factors in EHR data.

J Biomed Inform

September 2024

Center for Health AI and Synthesis of Evidence (CHASE), Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; The Graduate Group in Applied Mathematics and Computational Science, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Penn Institute for Biomedical Informatics (IBI), Philadelphia, PA, USA; Leonard Davis Institute of Health Economics, Philadelphia, PA, USA; Penn Medicine Center for Evidence-based Practice (CEP), Philadelphia, PA, USA. Electronic address:

Article Synopsis
  • This study proposes a new method to use multiple electronic health record (EHR)-derived phenotypes to reduce bias from phenotyping errors in EHR-based association studies, enhancing the efficiency of phenotype/exposure relationships.
  • The method combines various algorithm-derived phenotypes with a few validated outcomes, showing strong improvements in bias reduction and estimation efficiency during simulation tests and a real-world study on colon cancer recurrence.
  • Results indicate that this approach significantly outperforms single-phenotype methods, offering a statistically efficient way to tackle bias in situations where it's unclear which phenotype is the best.
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Purpose: Dementia is common among patients with primary open angle glaucoma (POAG) and neovascular age-related macular degeneration (nAMD). This study compares visit frequency, diagnostic test utilization, and treatment patterns for POAG and nAMD among persons with vs. without dementia.

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Implementation of immunotherapy in recurrent endometrial cancer: a real-world cohort study.

Am J Obstet Gynecol

November 2024

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Pennsylvania Health Systems, Philadelphia, PA; Department of Obstetrics and Gynecology, University of Pennsylvania Health Systems, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania Health Systems, Philadelphia, PA; Penn Center for Cancer Care Innovation, Abramson Cancer Center, University of Pennsylvania Health Systems, Philadelphia, PA; Abramson Cancer Center, Pennsylvania Hospital, Philadelphia, PA.

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Article Synopsis
  • The study highlights a significant gap in research regarding burnout and psychological distress among Hispanic nurses compared to their non-Hispanic White counterparts.
  • It analyzed data from a survey of nurses, revealing that Hispanic nurses reported higher burnout levels, although this association weakened when factoring in their work environments and nurse characteristics.
  • The findings call for targeted strategies to enhance the workplace support for Hispanic nurses, particularly focusing on the needs of younger nurses.
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Hospital-free days: A novel measure to study outcomes for emergency department care.

Acad Emerg Med

October 2024

Center for Emergency Care Policy and Research, Department of Emergency Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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Importance: The Centers for Medicare & Medicaid Services Innovation Center Independence at Home (IAH) demonstration, a test of home-based primary care operating in a value-based shared-savings payment model, ended December 2023 after a decade of consistently showing savings to Medicare. It is important to assess whether high-need, IAH-qualified beneficiaries continue to pose a growing challenge to traditional Medicare (TM) or if Medicare Advantage (MA), with programmatic features favorable to caring for this subset of the general Medicare population, can disproportionately provide such care.

Objective: To examine the size and share of IAH-qualified beneficiaries in TM and MA.

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Background: Screening for health-related social needs (HRSN) has become more widespread but the best method of delivering the screening tool is not yet known.

Objective: Describe HRSN screening completion rate, specifically portal-based and in-person tablet-based screening.

Design: Cross-sectional retrospective observational study.

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