2,973 results match your criteria: "Leonard Davis Institute of Health Economics.[Affiliation]"

Background: Enrollment of Medicare beneficiaries in medicare advantage (MA) plans has been steadily increasing. Prior research has shown differences in healthcare access and outcomes based on Medicare enrollment status. This study sought to compare utilization of minimally invasive colorectal cancer (CRC) surgery and postoperative outcomes between MA and Fee-for-Service (FFS) beneficiaries.

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Importance: Clinicians are a key component of preexposure prophylaxis (PrEP) care. Yet, no prior studies have quantitatively investigated how PrEP adherence differs by clinician specialty.

Objective: To understand the association between prescribing clinician specialty and patients not picking up (reversal/abandonment) their initial PrEP prescription.

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Article Synopsis
  • ST-segment elevation myocardial infarction complicated by cardiogenic shock (STEMI-CS) has high mortality rates, especially for patients admitted during off-hours, known as the "off-hours effect."
  • This study analyzed registry data of 1,207 patients treated with Impella, revealing that 42.1% of off-hours admissions resulted in death compared to 30.3% during on-hours.
  • The research concluded that off-hours admissions were linked to a 60% increased risk of 30-day mortality, emphasizing the need for improved cardiovascular care and timely treatment during off-hours.
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Trends in Post-Acute Care use in Medicare Advantage Versus Traditional Medicare: A Retrospective Cohort Analysis.

J Am Med Dir Assoc

October 2024

Center for Health Equity Research and Promotion, Corporal Crescenz VA Medical Center, Philadelphia, PA, USA; Division of General Internal Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA.

Objectives: We sought to describe national trends in hospitalization and post-acute care utilization rates in skilled nursing facilities (SNFs) and home health (HH) for both Medicare Advantage (MA) and Traditional Medicare (TM) beneficiaries, reaching up to the COVID-19 pandemic (2015-2019).

Design: Retrospective, observational using 100% sample of Medicare Provider Analysis and Review file (MedPAR), the Medicare Beneficiary Summary File, the Minimum Data Set (MDS), and the Outcome and Assessment Information Set (OASIS).

Setting And Participants: Medicare beneficiaries aged 66 and older enrolled in MA or TM who were hospitalized and discharged alive.

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The Effect of a Post-Bronchodilator FEV/FVC < 0.7 on COPD Diagnosis and Treatment: A Regression Discontinuity Design.

medRxiv

August 2024

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines recommend the diagnosis of chronic obstructive pulmonary disease (COPD) only in patients with a post-bronchodilator forced expiratory volume in 1 second to forced vital capacity ratio (FEV/FVC) less than 0.7. However the impact of this recommendation on clinical practice is unknown.

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Article Synopsis
  • Some people with dementia and their families prefer to stay at home as they feel it's the best care, but this isn't the same for everyone.
  • A study with interviews found that many families avoid moving to care facilities until it's absolutely necessary, often because of fear or guilt.
  • It's important for care programs to consider all the reasons families make decisions about where to live and to help them understand their options better.
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Deimplementation of Ineffective and Harmful Medical Practices: A Data-Driven Commentary.

Am J Epidemiol

August 2024

Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Deimplementation is the discontinuation or abandonment of medical practices that are ineffective or of unclear effectiveness, ranging from simply unhelpful to harmful. With epidemiology expanding to include more translational sciences, epidemiologists can contribute to deimplementation through defining evidence, establishing causality, and advising on study design. An estimated 10-30% of healthcare practices have minimal to no benefit to patients and should be targeted for deimplementation.

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Racial, Ethnic, Socioeconomic, and Geographic Inequities in Access to Mechanical Circulatory Support.

J Soc Cardiovasc Angiogr Interv

January 2024

Penn Cardiovascular Outcomes, Quality, and Evaluative Research Center, University of Pennsylvania, Philadelphia, Pennsylvania.

Background: Hospital admissions for cardiogenic shock have increased in the United States. Temporary mechanical circulatory support (tMCS) can be used to acutely stabilize patients. We sought to evaluate the presence of racial, ethnic, and socioeconomic inequities in access to MCS in the United States among patients with cardiogenic shock.

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Objective: To determine whether mandatory participation by hospitals in bundled payments for lower extremity joint replacement (LEJR) was associated with changes in outcome disparities for patients dually eligible for Medicare and Medicaid.

Data Sources And Study Setting: We used Medicare claims data for beneficiaries undergoing LEJR in the United States between 2011 and 2017.

Study Design: We conducted a retrospective observational study using a differences-in-differences method to compare changes in outcome disparities between dual-eligible and non-dual eligible beneficiaries after hospital participation in the Comprehensive Care for Joint Replacement (CJR) program.

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Continuous pulse oximetry (cSpO) monitoring use outside established guidelines is common in children hospitalized with bronchiolitis. We analyzed clinicians' real-time rationale for continuous monitoring in stable children with bronchiolitis not requiring supplemental oxygen. Data for this study were collected as part a multicenter deimplementation trial for cSpO in children hospitalized with bronchiolitis.

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Introduction: Breast cancer treatment patterns and quality of care among patients experiencing incarceration are underexplored. This study examined associations between incarceration and breast cancer disease and treatment characteristics.

Methods: This retrospective analysis was conducted at a tertiary center in the Southeastern United States that serves as the state's safety-net hospital and primary referral site for the state's prisons.

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A generalist vision-language foundation model for diverse biomedical tasks.

Nat Med

November 2024

Department of Computer Science and Engineering, Lehigh University, Bethlehem, PA, USA.

Article Synopsis
  • Traditional biomedical AI models are limited in flexibility and can't easily use comprehensive information for real-world applications.
  • BiomedGPT is introduced as an open-source, lightweight generalist AI model capable of performing various biomedical tasks, achieving top results in many experiments.
  • It shows strong performance in tasks like radiology question answering, report generation, and summarization, indicating that training with diverse data can enhance the utility of biomedical AI in diagnosis and workflow efficiency.
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There have been repeated calls for academic institutions to develop policies and procedures to manage institutional conflicts of interest (ICOI) arising from technology transfer activities. While prior research has examined adoption of ICOI policies by medical schools and universities, little is known about how these institutions handle ICOI in practice, hindering the development of evidence-based recommendations to improve ICOI management. To address this gap, we conducted semi-structured interviews with 25 senior administrators responsible for research integrity and conflict of interest issues at academic institutions.

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Current critical care practice does not integrate social determinants of health (SDOH) in systematic or standardized ways. Routine assessment of SDOH in the intensive care unit (ICU) may improve clinical decision making, patient- and family-centered outcomes, and clinician well-being. Given that the appropriateness and feasibility of SDOH assessment in the ICU is unknown, we aimed to understand how ICU clinicians think about and use SDOH.

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Background: In 2019, New York City (NYC) launched NYC Care (NYCC), a healthcare access program through NYC Health + Hospitals (H + H) for individuals who are ineligible for federally funded health insurance programs or cannot purchase insurance through the State Marketplace, predominantly undocumented individuals.

Objective: To examine the sociodemographic characteristics, healthcare use patterns, and chronic disease quality measures for diabetes mellitus (DM) and hypertension among NYCC patients compared with Medicaid patients seen at NYC H + H.

Design: Observational study.

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Endophthalmitis Rates and Types of Treatments After Intraocular Procedures.

JAMA Ophthalmol

September 2024

Vickie and Jack Farber Vision Research Center at Wills Eye, Wills Eye Hospital, Philadelphia, Pennsylvania.

Importance: Long-term trend analyses of overall endophthalmitis rates and treatment patterns are scarce. It is also unknown if the deviation from the recommendations of the Endophthalmitis Vitrectomy Study toward decreased utilization of vitrectomy is associated with different vision outcomes.

Objective: To determine whether the rate of endophthalmitis after intraocular procedures or the primary treatment (prompt vitrectomy vs tap and inject) for endophthalmitis has changed over the past 20 years.

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Grace periods and exposure misclassification in self-controlled case-series studies of drug-drug interactions.

Am J Epidemiol

July 2024

Center for Real-World Safety and Effectiveness of Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Article Synopsis
  • The self-controlled case-series (SCCS) design is used in studies to evaluate drug-drug interactions (DDIs), focusing on the comparison of incidence rates when taking two drugs together versus one alone.
  • Inaccuracies can arise when inferring day-level drug exposure from dispensing claims, which may lead to biased incidence rate ratios (IRRs), particularly when using grace periods that assume treatment effects continue after medication runs out.
  • Research findings indicate that misclassifying the precipitant (the drug causing the interaction) consistently biases the IRR towards null, while misclassifying the object drug can bias it in various directions; to reduce bias, it is recommended to avoid grace periods for object drugs and include a washout period after
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@ramsedhom and colleagues highlight the opportunity of palliative care to bend the cost (and value) curve in cancer. Enhanced, early, and expanded access to PC offers benefits to inpatients with cancer and cost savings to health systems and payors.

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Article Synopsis
  • The study investigates the relationship between CPR duration and survival outcomes in hospitalized children who experience cardiac arrest and do not achieve return of circulation (ROC).
  • It involved two analyses: a patient-level examination of CPR duration factors and a hospital-level analysis looking at the association between hospital median CPR duration and survival rates among patients without ROC.
  • Results indicated that among 13,899 CPR events, 3,859 patients did not achieve ROC, with a longer median CPR duration observed in those who did not survive, highlighting the significance of CPR duration in cardiac arrest survival.
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Nursing Home Compare star ratings before versus after a change in nursing home ownership.

J Am Geriatr Soc

October 2024

Division of General Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background: Efforts to increase transparency and accountability of nursing homes, and thus improve quality, now include information about changes in nursing home ownership. However, little is known about how change in ownership affects nursing home quality.

Methods: We conducted a retrospective cohort study of 15,471 U.

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Background: Maintaining balanced blood product ratios during damage control resuscitation (DCR) is independently associated with improved survival. We hypothesized that real-time performance improvement (RT-PI) would increase adherence to DCR best practice.

Study Design And Methods: From December 2020-August 2021, we prospectively used a bedside RT-PI tool to guide DCR in severely injured patients surviving at least 30 min.

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