2,973 results match your criteria: "Leonard Davis Institute of Health Economics.[Affiliation]"

Risk of Opioid Overdose Associated with Concomitant Use of Methadone and Statins.

Clin Pharmacol Ther

February 2025

Center for Real-World Effectiveness and Safety of Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Article Synopsis
  • * A study using Medicaid claims from 2003 to 2020 assessed the overdose rates among users of methadone and different statins, specifically comparing P-gp-inhibiting statins (simvastatin, atorvastatin, lovastatin) with rosuvastatin as a control.
  • * Results showed no significant association between the use of P-gp-inhibiting statins and opioid overdose risk, indicating that using these statins alongside methadone may not increase the risk compared to using rosuvastatin.
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Background: The organizational culture (shared beliefs, perceptions, and values) of teams informs their behaviours and practices. Little is known about organizational culture for resuscitation teams. Our objective was to develop a reliable and valid resuscitation-specific organizational culture instrument (ROCI) with the goal of improving team performance.

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Trends in severe maternal morbidity following an institutional team goal strategy for disparity reduction.

Am J Obstet Gynecol MFM

December 2024

Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA (Hirshberg, James, Levine, Howell, and Srinivas); Leonard Davis Institute of Health Economics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA (Levine, Howell, and Srinivas).

Background: Racial disparities in maternal pregnancy outcomes, specifically in morbidity and mortality, are persistent in the U.S., and a multifaceted approach to mitigating these disparate outcomes is critical.

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Objective: To examine the association of Medicaid home- and community-based services (HCBS) expenditures on the home care workforce.

Data Sources/study Setting: We use two national, secondary data sources from 2008 to 2019: state-level Medicaid HCBS expenditures and the American Community Survey, in which we identify direct care workers in the home (i.e.

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A study of implementation factors for a novel approach to clinical trials: constructs for consideration in the coordination of direct-to-patient online-based medical research.

BMC Med Res Methodol

October 2024

Division of Rheumatology, Department of Medicine, and the Division of Epidemiology, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, United States.

Background: Traditional medical research infrastructures relying on the Centers of Excellence (CoE) model (an infrastructure or shared facility providing high standards of research excellence and resources to advance scientific knowledge) are often limited by geographic reach regarding patient accessibility, presenting challenges for study recruitment and accrual. Thus, the development of novel, patient-centered (PC) strategies (e.g.

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Associations Between Dry Eye Disease and Mental Health Conditions in the All of Us Research Program.

Am J Ophthalmol

February 2025

Department of Ophthalmology, Perelman School of Medicine, Scheie Eye Institute, The University of Pennsylvania (A.T.Z., J.H., G.-S.Y.), Philadelphia, Pennsylvania, USA; Center for Preventive Ophthalmology and Biostatistics, Department of Ophthalmology, Perelman School of Medicine, The University of Pennsylvania (J.H., G.-S.Y.), Philadelphia, Pennsylvania, USA. Electronic address:

Purpose: To determine the association between dry eye disease (DED) and mental health conditions in a sociodemographically diverse nationwide population of Americans.

Design: Cross-sectional study.

Methods: We used the National Institute of Health's All of Us Research Program database to identify 18257 participants with DED who were propensity score matched in a 1:3 ratio to participants without DED.

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Importance: In 2021, the Centers for Medicare & Medicaid Services designated a new category of dual-eligible special needs plans (D-SNPs) with exclusively aligned enrollment (receive Medicare and Medicaid benefits through the same plan or affiliated plans within the same organization).

Objective: To assess the availability of and enrollment in D-SNPs with exclusively aligned enrollment and to compare the characteristics of beneficiaries enrolled in D-SNPs with exclusively aligned enrollment available vs beneficiaries without such enrollment available.

Design, Setting, And Participants: Full-benefit beneficiaries enrolled in D-SNPs for 6 months or longer in 2021 or 2022.

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Therapeutic exercise has not been widely adopted in pediatric pulmonary hypertension (PH), despite adult data supporting its safety and efficacy. While physical limitations may prevent children with PH from participating in physical activity, other barriers to and facilitators of physical activity are unknown. Youth ages 8-18 years with World Symposium of PH diagnostic Groups 1-4, functional class I or II, and ambulatory status were prospectively enrolled in a cross-sectional study including separate 30-min participant and caregiver interviews regarding attitudes toward physical activity and a proposed exercise intervention in pediatric PH.

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AGREE II Evaluation of Clinical Practice Guidelines on Generalized Cancer Pain Management.

Pain Manag Nurs

October 2024

Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA. Electronic address:

Purpose: While several clinical practice guidelines (CPGs) exist to guide clinical decision-making in patients with generalized cancer pain, to date there has been no comprehensive review of their quality. Our aim was to address this deficiency via the Appraisal of Guidelines for Research and Evaluation (AGREE II) tool.

Design: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline-based systematic literature search followed by AGREE II appraisal of identified CPGs.

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Nursing burnout remains a public health crisis. However, few stakeholders have considered the disproportionate toll of burnout among nurses of color, including nurses identifying as Black, Hispanic/Latino, or Native American. We convened a one-day conference, titled Solutions to Health Inequities and Nurses' Emotional Exhaustion (SHINE), to begin identifying contributing factors and solutions to burnout amongst nurses of color.

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Article Synopsis
  • The study evaluated a virtual parenting program called PriCARE, designed to help improve parenting skills and reduce child behavioral issues during the COVID-19 pandemic.
  • Caregivers of children aged 2 to 6 were randomly assigned to either the PriCARE intervention or a waitlist control group, with various measures taken before and after the program.
  • Results showed that those who participated in PriCARE experienced significant improvements in parenting behavior and child problem behaviors compared to the control group, indicating that virtual positive parenting interventions can be effective.
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Article Synopsis
  • Stigmatizing language in electronic health records (EHRs) can perpetuate negative stereotypes and undermine trust for patients from minoritized groups, especially related to their clinical histories.* -
  • This study aimed to analyze the prevalence of doubt-casting language in admission notes, specifically looking at how it varies based on patient race and ethnicity.* -
  • Utilizing natural language processing on over 54,000 admission notes from a diverse patient population, the researchers focused on the use of certain linguistic terms that reflect the degree of certainty about patients' reports of their health experiences.*
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Changes in Antipsychotic Medication Adherence Among Medicaid Beneficiaries with Schizophrenia During COVID-19.

Adm Policy Ment Health

October 2024

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market St, 3rd Floor, Philadelphia, PA, 19104, USA.

To identify patterns of medication adherence during the pandemic and factors associated with these patterns among Medicaid-enrolled individuals with schizophrenia who had highly adherent medication use prior to the COVID-19 pandemic. We used Medicaid claims from Philadelphia to identify individuals with schizophrenia ≥ 18 years of age, their demographic characteristics, and health service use. We used group trajectory models to identify adherence trends, and ANOVA to examine associations between adherence groups and demographic characteristics and service use.

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End-of-Life Health Care Service Use and Cost Among Medicare Decedents With Neurodegenerative Diseases.

Neurology

November 2024

From the Department of Neurology (W.W.A., N.D., H.E., A.L.C.S., A.W.W.), Translational Center of Excellence for Neuroepidemiology and Neurology Outcomes Research (W.W.A., N.D., A.L.C.S., A.W.W.), Perelman School of Medicine, Department of Medical Ethics and Health Policy (C.S., N.B.C.), Leonard Davis Institute of Health Economics (N.D., A.L.C.S., N.B.C., A.W.W.), and Department of Biostatistics, Epidemiology, and Informatics (A.L.C.S., J.T.F., A.W.W.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Article Synopsis
  • The study investigates healthcare utilization and costs during the end-of-life period for Medicare beneficiaries with neurodegenerative diseases (like Alzheimer’s, Parkinson’s, and ALS) compared to those with cancer, specifically malignant brain tumors and pancreatic cancer.
  • Researchers analyzed 2018 data, looking at demographics, clinical characteristics, and healthcare service usage over the final year of life, focusing particularly on emergency department visits, hospitalizations, and hospice care.
  • Results showed that individuals with neurodegenerative diseases were generally older and more reliant on Medicaid, had higher odds of emergency department use but lower hospitalization rates compared to cancer patients, with overall healthcare costs primarily driven by inpatient care.
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Article Synopsis
  • A mobile texting platform designed for interstitial cystitis/bladder pain syndrome (IC/BPS) patients was created to help with self-management over six weeks, featuring various treatment modules and automated messages.
  • Patient engagement was high at 76.9%, with pelvic floor physical therapy being the most popular module, and the overall usability of the platform received a high score.
  • Improvements were noted in patient-physician communication satisfaction, pain self-efficacy, and urinary symptoms, suggesting the platform could enhance self-management and support clinicians in managing IC/BPS patients effectively.
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A Qualitative Study Identifying the Potential Risk Mechanisms Leading to Hospitalization for Patients With Chronic Lung Disease.

CHEST Pulm

September 2024

Palliative and Advanced Illness Research (PAIR) Center, University of Pennsylvania, Philadelphia, PA; Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania, Philadelphia, PA; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA; Center for Health Incentives and Behavioral Economics, University of Pennsylvania, Philadelphia, PA; Department of Medical Ethics and Health Policy, University of Pennsylvania, Philadelphia, PA.

Article Synopsis
  • Many care management programs for chronic lung disease fail to effectively reduce hospitalizations because they don't address the specific mechanisms causing them.
  • The study examined the experiences of 22 patients with chronic lung disease who were hospitalized, focusing on common underlying issues that led to their acute exacerbations.
  • Key findings included factors like difficulty managing symptoms at home, barriers to accessing healthcare, ongoing functional limitations, and mental health issues, which often existed long before hospitalization.
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Importance: Socially vulnerable patients with symptomatic cholelithiasis are more likely to face barriers to accessing surgical care. This barrier to access can lead to delays in treatment, the need for emergent cholecystectomy, and worse outcomes.

Objectives: To determine the effectiveness of telemedicine vs in-person surgical consultation on access to elective cholecystectomy in socially vulnerable populations and to evaluate the association of scheduling navigation with access to elective cholecystectomy in these populations.

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Article Synopsis
  • The study aimed to determine if there are racial disparities in the receipt of radiation treatment and outcomes for Medicare patients with cervical cancer who were eligible for primary radiation-chemotherapy.
  • The analysis included 1,038 patients (mostly White and some Black), comparing their treatment rates and survival outcomes, revealing that Black patients were more likely to receive radiation therapy but had similar survival rates as White patients.
  • Ultimately, the findings suggested that while Black Medicare patients received more radiation therapy, both racial groups experienced no significant difference in overall survival or cancer-specific survival rates.
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Unlabelled: Public schools are a major provider of mental health services for children in the US. Mental and behavioral health services range from universal programming to individualized clinical supports to address student needs. These services in schools are delivered by various professionals including non-teaching and teaching school personnel, school-employed clinicians, and/or contracted community mental health partners.

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