2,982 results match your criteria: "Leonard Davis Institute of Health Economics[Affiliation]"

Current critical care practice does not integrate social determinants of health (SDOH) in systematic or standardized ways. Routine assessment of SDOH in the intensive care unit (ICU) may improve clinical decision making, patient- and family-centered outcomes, and clinician well-being. Given that the appropriateness and feasibility of SDOH assessment in the ICU is unknown, we aimed to understand how ICU clinicians think about and use SDOH.

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Background: In 2019, New York City (NYC) launched NYC Care (NYCC), a healthcare access program through NYC Health + Hospitals (H + H) for individuals who are ineligible for federally funded health insurance programs or cannot purchase insurance through the State Marketplace, predominantly undocumented individuals.

Objective: To examine the sociodemographic characteristics, healthcare use patterns, and chronic disease quality measures for diabetes mellitus (DM) and hypertension among NYCC patients compared with Medicaid patients seen at NYC H + H.

Design: Observational study.

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Endophthalmitis Rates and Types of Treatments After Intraocular Procedures.

JAMA Ophthalmol

September 2024

Vickie and Jack Farber Vision Research Center at Wills Eye, Wills Eye Hospital, Philadelphia, Pennsylvania.

Importance: Long-term trend analyses of overall endophthalmitis rates and treatment patterns are scarce. It is also unknown if the deviation from the recommendations of the Endophthalmitis Vitrectomy Study toward decreased utilization of vitrectomy is associated with different vision outcomes.

Objective: To determine whether the rate of endophthalmitis after intraocular procedures or the primary treatment (prompt vitrectomy vs tap and inject) for endophthalmitis has changed over the past 20 years.

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Grace periods and exposure misclassification in self-controlled case-series studies of drug-drug interactions.

Am J Epidemiol

July 2024

Center for Real-World Safety and Effectiveness of Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Article Synopsis
  • The self-controlled case-series (SCCS) design is used in studies to evaluate drug-drug interactions (DDIs), focusing on the comparison of incidence rates when taking two drugs together versus one alone.
  • Inaccuracies can arise when inferring day-level drug exposure from dispensing claims, which may lead to biased incidence rate ratios (IRRs), particularly when using grace periods that assume treatment effects continue after medication runs out.
  • Research findings indicate that misclassifying the precipitant (the drug causing the interaction) consistently biases the IRR towards null, while misclassifying the object drug can bias it in various directions; to reduce bias, it is recommended to avoid grace periods for object drugs and include a washout period after
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@ramsedhom and colleagues highlight the opportunity of palliative care to bend the cost (and value) curve in cancer. Enhanced, early, and expanded access to PC offers benefits to inpatients with cancer and cost savings to health systems and payors.

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Article Synopsis
  • The study investigates the relationship between CPR duration and survival outcomes in hospitalized children who experience cardiac arrest and do not achieve return of circulation (ROC).
  • It involved two analyses: a patient-level examination of CPR duration factors and a hospital-level analysis looking at the association between hospital median CPR duration and survival rates among patients without ROC.
  • Results indicated that among 13,899 CPR events, 3,859 patients did not achieve ROC, with a longer median CPR duration observed in those who did not survive, highlighting the significance of CPR duration in cardiac arrest survival.
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Nursing Home Compare star ratings before versus after a change in nursing home ownership.

J Am Geriatr Soc

October 2024

Division of General Internal Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background: Efforts to increase transparency and accountability of nursing homes, and thus improve quality, now include information about changes in nursing home ownership. However, little is known about how change in ownership affects nursing home quality.

Methods: We conducted a retrospective cohort study of 15,471 U.

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Background: Maintaining balanced blood product ratios during damage control resuscitation (DCR) is independently associated with improved survival. We hypothesized that real-time performance improvement (RT-PI) would increase adherence to DCR best practice.

Study Design And Methods: From December 2020-August 2021, we prospectively used a bedside RT-PI tool to guide DCR in severely injured patients surviving at least 30 min.

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Gender Differences in the Diagnosis of Chronic Obstructive Pulmonary Disease after Spirometry.

medRxiv

July 2024

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: Women are more likely than men to report delays in the diagnosis of chronic obstructive pulmonary disease (COPD), though the etiology of these delays is unknown. We sought to test whether delays in COPD diagnosis persist after the performance of spirometry.

Methods: We used the Optum Labs Data Warehouse to identify patients 18 years of age and older without a prior diagnosis of COPD, with a post-bronchodilator forced expiratory volume in 1 second (FEV) to forced vital capacity (FVC) ratio of less than 0.

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Trapped in Violence: A Life Table Analysis of Firearm Injury and Death Among Adolescent Black Males.

J Adolesc Health

December 2024

Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Purpose: We report the chances of 14-year-old males becoming victims of firearm injury or death before age 25 in Philadelphia, Pennsylvania.

Methods: Using life table methods, we followed 4,501 Black males aged 14 years, and a comparison group of 1,751 White males, over 11 years.

Results: Among 14-year-old Black males, the risk of a nonfatal firearm injury before age 25 was 10.

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Article Synopsis
  • This study focuses on comparing how family members perceive the quality of death in patients who died from cardiovascular disease (CVD) versus cancer.
  • A survey was sent out to family members of deceased CVD patients, with results showing that the quality of death score for CVD patients was lower compared to cancer patients receiving palliative care, but higher than those in general wards.
  • Ultimately, the findings suggest that while the quality of death for CVD patients is generally perceived as lower than for those in palliative care, it does not significantly differ from cancer patients in non-palliative care settings.
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What Do We Mean by Sharing of Patient Data? DaSH: A Data Sharing Hierarchy of Privacy and Ethical Challenges.

Appl Clin Inform

October 2024

Department of Biostatistics (Health Informatics), Bioethics Center, Information Society Project, Solomon Center for Health Law and Policy, Center for Biomedical Data Science, and Program for Biomedical Ethics, Yale University, New Haven, Connecticut, United States.

Background:  Clinical data sharing is common and necessary for patient care, research, public health, and innovation. However, the term "data sharing" is often ambiguous in its many facets and complexities-each of which involves ethical, legal, and social issues. To our knowledge, there is no extant hierarchy of data sharing that assesses these issues.

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Purpose: It is unknown whether Medicaid expansion under the Affordable Care Act (ACA) or state-level policies mandating Medicaid coverage of the routine costs of clinical trial participation have ameliorated longstanding racial and ethnic disparities in cancer clinical trial enrollment.

Methods: We conducted a retrospective, cross-sectional difference-in-differences analysis examining the effect of Medicaid expansion on rates of enrollment for Black or Hispanic nonelderly adults in nonobservational, US cancer clinical trials using data from Medidata's Rave platform for 2012-2019. We examined heterogeneity in this effect on the basis of whether states had pre-existing mandates requiring Medicaid coverage of the routine costs of clinical trial participation.

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Background: Text messaging has emerged as a popular strategy to engage patients after hospital discharge. Little is known about how patients use these programs and what types of needs are addressed through this approach.

Objective: The goal of this study was to describe the types and timing of postdischarge needs identified during a 30-day automated texting program.

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Performance of the open-first repair strategy in type A aortic dissection with mesenteric malperfusion syndrome eligible for delayed repair.

J Thorac Cardiovasc Surg

July 2024

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa; Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pa.

Article Synopsis
  • The study examines the efficacy of traditional open-first surgery compared to a nontraditional approach of delayed repair for patients with type A aortic dissection complicated by mesenteric malperfusion syndrome.
  • Out of 1228 patients treated, 77 had mesenteric malperfusion syndrome with an in-hospital mortality rate of 29%, which was lower than the 39% for those undergoing delayed repair.
  • Despite higher early mortality in the mesenteric malperfusion group, 10-year survival rates were similar for both treatment strategies, indicating that the open-first approach may be equally effective or superior to the delayed method.
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Article Synopsis
  • This review discusses how large databases contribute to gynecologic oncology research, highlighting their advantages and limitations.
  • It covers several key databases, including NCDB, SEER, and HCUP, detailing their data, access, and management features.
  • Understanding these databases aids readers and researchers in interpreting findings, evaluating new studies, and advancing impactful research in the field.
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Importance: Most dual-eligible Medicare-Medicaid beneficiaries are enrolled in bifurcated insurance programs that pay for different components of care. Therefore, policymakers are prioritizing expansion of integrated care plans (ICPs) that manage both Medicare and Medicaid benefits and spending.

Objective: To review evidence of the association between ICPs and health care spending, quality, utilization, and patient outcomes among dual-eligible beneficiaries.

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Education, organizational changes, and enforcement challenges of the 2019 flavored tobacco sales restriction in Massachusetts.

Drug Alcohol Depend

September 2024

University of Pennsylvania, Annenberg School for Communication, Philadelphia, PA, United States; University of Pennsylvania, Leonard Davis Institute of Health Economics, Philadelphia, PA, United States; Abramson Cancer Center, Tobacco and Environmental Carcinogenesis Program, Philadelphia, PA, United States. Electronic address:

Article Synopsis
  • - In November 2019, Massachusetts became the first state to restrict the sale of all flavored tobacco products and implemented additional tobacco control policies and insurance coverage for treatment, with implementation occurring between November 2019 and June 2020.
  • - A study was conducted through interviews with public health officials, school personnel, and healthcare providers, highlighting key themes such as the importance of education, organizational changes, and enforcement challenges.
  • - Findings revealed that challenges included pandemic restrictions and industry tactics, while facilitators included effective enforcement, advocacy, and coordination among organizations, providing valuable insights for other states looking to implement similar tobacco control policies.
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Longitudinal outcomes of thoracic endovascular aortic repair for ruptured thoracic aortic aneurysms.

J Thorac Cardiovasc Surg

July 2024

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa; Division of Vascular Surgery and Endovascular Therapy, University of Pennsylvania, Philadelphia, Pa.

Article Synopsis
  • This study investigates long-term outcomes of urgent thoracic endovascular aortic repair (TEVAR) for patients with ruptured thoracic aortic aneurysms (rTAA) compared to intact aneurysms (iTAA).
  • Among 321 patients treated, those with rTAA had lower short-term survival rates and higher incidences of complications, but similar long-term survival rates to iTAA patients if they survived the first 90 days.
  • The findings highlight that while immediate outcomes are worse for rTAA patients, their long-term survival becomes comparable to iTAA patients after a significant early survival period.
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