5,337 results match your criteria: "Lentigo"
Cutaneous melanoma in situ: a review.
Clin Exp Dermatol
February 2025
Department of Dermatology, Norfolk and Norwich University Hospital, Norwich, UK.
Cutaneous melanoma in situ (MIS), also known as 'stage 0 melanoma', is a collection of malignant melanocytes in the epidermis and epithelial adnexa, without evidence of microinvasion to the papillary dermis. Distinct histological subtypes include lentigo maligna (LM), superficial spreading (SS) MIS and acral lentiginous (AL) MIS. LM is the most common subtype, usually diagnosed later in life (median age at diagnosis of 66-72 years) and associated with cumulative ultraviolet radiation exposure.
View Article and Find Full Text PDFLentigo Maligna Part II: Management.
J Am Acad Dermatol
October 2024
Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:
Lentigo Maligna (LM) arises on chronically-sun damaged skin and can have extensive subclinical spread, often in functionally and cosmetically challenging areas. This two-part continuing medical education (CME) series reviews LM. Part I reviews epidemiology, risk factors, clinical presentation, diagnostic tools, biopsy technique, and histopathology of LM.
View Article and Find Full Text PDFLentigo Maligna Part I: Epidemiology, Risk Factors, and Diagnosis.
J Am Acad Dermatol
October 2024
Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:
Lentigo maligna (LM) is an increasingly common subtype of melanoma, presenting as a slow-growing tan-brown macule or patch with irregular borders arising on chronically solar-damaged skin. This two-part continuing medical education (CME) series provides an overview of LM. Part I reviews LM's epidemiology, risk factors, and clinical presentation.
View Article and Find Full Text PDFDermatoscopic Radial Rippling of Pigment: A Potential Indicator of Pigmented Bowen's Disease.
Skinmed
October 2024
Empire Dermatology (Private Practice), Syracuse, NY.
Article Synopsis
- - Pigmented Bowen's disease (pBD) is a rare form of Bowen's disease, making up only 1.67%-5.5% of lesions, and it can be mistaken for various skin conditions like actinic keratosis and melanoma.
- - This skin condition usually appears as a flat or slightly raised, scaly, and well-defined plaque, mainly affecting individuals in their sixties and is generally asymptomatic.
- - Key risk factors for developing pBD include HPV infection, exposure to arsenic and sunlight, ionizing radiation, and skin trauma.
A Review of Melanoma Subtypes: Genetic and Treatment Considerations.
J Surg Oncol
October 2024
Department of Surgical Oncology, Corewell Health, Grand Rapids, Michigan, USA.
Melanoma affects over one million people in the United States. This review explores genetic mutations and markers of all seven subtypes. Current treatment options and prognosis of each subtype are also discussed.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the challenges of diagnosing and managing cervical lesions in patients with Peutz-Jeghers syndrome (PJS) by analyzing MRI features in relation to pathological types.
- A total of 34 PJS patients were categorized into four groups based on their lesions, revealing significant differences in MRI characteristics, such as lesion extent and microcyst distribution.
- A new grading system was developed from these MRI findings to help assess the potential malignancy of cervical lesions, aiming to improve treatment recommendations and enhance collaboration between healthcare professionals.
A Novel Combination of BroadBand Light (BBL® HERO) and Nonablative Fractionated 1,927nm (MOXI) Laser for Addressing Solar Lentigines.
J Clin Aesthet Dermatol
January 2024
Ms. Hennessey is the Owner of Blush Aesthetics in Perrysburg and Toledo, Ohio, and Assistant Professor, Nursing, Gonzaga University in Spokane, Washington.
Article Synopsis
- Solar lentigo is a common skin condition that can impact individuals of any age or ethnicity.
- A study evaluated the effectiveness of combining two treatments, BBL® HERO (a pulsed light device) and MOXI (a nonablative laser), for reducing these brown spots on the face during a single session.
- Results showed significant improvement in the appearance of solar lentigines in nine patients, with some experiencing continued benefits nearly 20 months after treatment.
Lentigo Maligna and Lentigo Maligna Melanoma of the External Ear: Clinical and Dermoscopic Features of 19 Patients.
Exp Dermatol
October 2024
Oncologic Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Article Synopsis
- External ear lentigo maligna/lentigo melanoma (LM/LMM) accounts for 1%-4% of all primary skin melanomas, and dermoscopy has greatly improved early detection over the last 20 years, especially with new diagnostic features like perifollicular linear projections (PLP).
- The study focused on 19 patients from the Oncologic Dermatology Unit in Bologna, investigating dermoscopic traits and the patients' clinical data, revealing that most patients were older males with an average age of 69.8 years.
- Results indicated that lentigo melanoma (LMM) tends to be larger (more than twice the size) and more commonly presents in older patients than lentigo maligna (LM), with
Incomplete Excision Rate for Lentigo Maligna and Associated Risk Factors.
Acta Derm Venereol
October 2024
Department of Dermatology and Venereology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Dermatology and Venereology, Gothenburg, Sweden.
Article Synopsis
- * Risk factors identified for higher IER included lesions on the head and neck, clinical excision margins less than 5 mm, and the use of preoperative partial biopsies.
- * The research suggests careful surgical planning for excising LMs, particularly those ≥ 20 mm and in challenging anatomical areas, and that plastic surgeons had higher IERs compared to dermatologists.
Article Synopsis
- The study investigates the effectiveness of a surgical logbook for clinicians to document skin surgeries and analyze their outcomes, especially focusing on excision rates in a dermatology department.
- Data was collected over a six-year period from over 5000 skin excisions, revealing a high overall complete excision rate of 97.07% and good diagnostic accuracy for various skin cancers.
- The findings suggest that the logbook serves as a valuable educational and analytical tool that can enhance surgical practices and improve excision outcomes in clinicians' careers.
Mohs Micrographic Surgery With Melanocytic Immunostains for T1a/b Invasive Melanoma Yields <1% Local Recurrence and Disease-specific Mortality.
Dermatol Surg
February 2025
Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
Article Synopsis
- The study reviews the increasing use of Mohs micrographic surgery with melanocytic immunostains (MMS-I) for treating cutaneous melanoma over a decade.
- It analyzed data from 352 patients, primarily older males, with most tumors classified as early-stage T1a/b and lentigo maligna subtype.
- The findings showed low rates of local recurrence (1.4%) and melanoma-specific deaths (0.9%), indicating that MMS-I is effective for T1a/b melanomas.
Improved disease-specific survival in lentigo maligna treated with Mohs surgery over wide local excision: a retrospective cohort analysis.
Br J Dermatol
January 2025
Department of Dermatology, University of Nebraska Medical Center, Omaha, NE, USA.
Neurotropism detected during Mohs micrographic surgery for melanoma in situ.
JAAD Case Rep
October 2024
Mountain West Dermatology, Grand Junction, Colorado.
A qualitative research on reproductive concerns of the patients with Peutz-Jeghers syndrome.
J Psychosom Obstet Gynaecol
December 2024
Department of Nursing, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, China.
Article Synopsis
- The study aims to explore the experiences and fertility concerns of patients with Peutz-Jeghers syndrome (PJS), focusing on their real needs.
- It involved interviews with 16 patients (13 women and 3 male partners) and identified five key themes related to reproduction and support challenges.
- The findings highlight the necessity for tailored psychological support for PJS patients, which should involve healthcare professionals, family, and social networks to address their reproductive concerns effectively.
Wood's Light in Inflammatory And Autoimmune Dermatoses, Infections and Skin Cancer.
Actas Dermosifiliogr
March 2025
Servicio de Dermatología, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, España; Servicio de Dermatología, Hospital de Figueres, Fundació Salut Empordà, Figures, Girona, España. Electronic address:
Article Synopsis
- Wood's light (WL) is an effective and inexpensive diagnostic tool, but its usage is not very common among dermatologists.
- In conditions like porokeratosis and various pigmentary disorders, WL shows specific fluorescence patterns that help in diagnosis, such as the "diamond necklace" sign for porokeratosis and bluish fluorescence for vitiligo.
- WL is also valuable in identifying skin infections with distinct fluorescence colors, and it aids in determining surgical margins for certain skin cancers, although results can vary.
Refractory solar lentigines successfully treated with 532-nm nanosecond Nd:YAG Vasculature Salvage Laser Surgery (VSLS) system: Case series.
Skin Res Technol
September 2024
Department of Dermatology, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
Article Synopsis
- - Solar lentigo is a common skin condition caused by sun exposure, characterized by increased melanocyte activity and melanin accumulation, which can lead to complications from traditional treatments like prolonged redness and hyperpigmentation.
- - In a study involving six Korean patients, the Vasculature Salvage Laser Surgery (VSLS) system, using a specific laser technique, was employed to treat solar lentigo in a single session with follow-ups from 3 to 10 weeks.
- - Results showed complete removal of the lesions with no post-inflammatory hyperpigmentation and only mild temporary redness as a side effect, indicating that VSLS may be a safer and more effective option, although further research is needed for long-term evaluation.
Postoperative risk assessment of post-inflammatory hyperpigmentation and the efficacy of delayed prevention following 532 nm Q-switched Nd:YAG laser treatment of solar lentigines: a randomized controlled study.
J Dermatolog Treat
December 2024
Department of Dermatology, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea.
Article Synopsis
- Post-inflammatory hyperpigmentation (PIH) is a common issue after laser treatments, but there are limited studies on its risks.
- A study evaluated the risk of PIH after using a specific laser for treating solar lentigines and the effectiveness of a triple combination cream (TCC) to prevent it.
- Findings showed that 55.3% of untreated lesions developed PIH, while using TCC reduced this number to 31%. Increased skin redness and outdoor activity were identified as significant risk factors for PIH.
Reflectance confocal microscopy to diagnose malignant melanoma and lentigo maligna in the UK: a single-centre prospective observational trial.
Br J Dermatol
December 2024
Cellular Pathology Services, Watford, UK.
Article Synopsis
- Previous research on Reflectance Confocal Microscopy (RCM) showed it was effective in diagnosing Malignant Melanoma (MM) but lacked studies in the UK perspective.
- This study aimed to test RCM's ability to diagnose MM and lentigo maligna (LM) in a UK setting, analyzing 597 patients with suspected cases.
- Results highlighted RCM's high sensitivity (94.2%) and specificity (83.2%) for diagnosing MM and LM, suggesting its routine use by trained dermatologists could enhance diagnostic accuracy in clinics.
Efficacy of traditional Chinese medicines in the treatment of solar lentigo based on network pharmacology and experimental validation.
J Cosmet Dermatol
December 2024
Foshan Conney Allan Biotechnology Co. Ltd, Foshan, China.
Article Synopsis
- Solar lentigo is a common skin condition that can be effectively treated using a combination of traditional Chinese medicines and their active compounds.
- The study employed advanced techniques like liquid chromatography-mass spectrometry and network pharmacology to identify key compounds and assess their effects on pigmentation in both mice and humans.
- Results showed that the treatment significantly reduced UVB-induced pigmentation and improved skin health, confirming the potential of TCMM as a comprehensive treatment strategy.
Correction: Utilizing deep learning model for assessing melanocytic density in resection margins of lentigo maligna.
Diagn Pathol
September 2024
Department of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Treatment options for a large facial lentigo maligna.
Aust J Gen Pract
September 2024
FACD, Director of Dermatology, Mater Hospital, Brisbane, Qld; Dermatologist, South East Dermatology, Annerley, Qld; Associate Professor, University of Queensland, Medical Faculty, Brisbane, Qld.
STK11 Adnexal Tumor: Exploring the Association With Peutz-Jeghers Syndrome and its Distinction From Morphologic Mimickers.
Adv Anat Pathol
January 2025
Department of Pathology, Massachusetts General Hospital, Boston, MA.
STK11 adnexal tumor is a novel malignant neoplasm of uncertain histogenesis frequently arising in a para-adnexal location and associated with Peutz-Jeghers syndrome in ∼50% of patients. Its broad morphologic spectrum and nonspecific immunohistochemical profile has resulted in misclassification in the past as a variety of other neoplasms including those of wolffian, sex cord-stromal, mesothelial, and epithelial derivation. This review focuses on the spectrum of adnexal neoplasms that may develop in Peutz-Jeghers syndrome, with particular emphasis on STK11 adnexal tumor and its differential diagnosis.
View Article and Find Full Text PDFFrequency of BRAF Mutations in Dysplastic Nevi, Lentigo Maligna, and Melanoma In Situ.
J Clin Med
August 2024
Department of Dermatovenereology, Sestre Milosrdnice University Hospital Center, HR-10000 Zagreb, Croatia.
Article Synopsis
- In melanomas, BRAF gene mutations are common early events, and this study aimed to compare their frequency in dysplastic nevi (ND) and melanomas in situ (MIS) while examining correlations with clinical factors.
- A total of 175 patients were analyzed, revealing a significant correlation between BRAF mutations and the diagnosis of MIS, while patients with lentigo maligna (LM) had fewer mutations compared to those with ND and MIS.
- The study concluded that while BRAF mutations are essential in ND, they alone are insufficient to trigger melanoma development, enhancing understanding of melanoma's etiology and the role of ND as potential precursors.
Comparison of Ophthalmologists versus Dermatologists for the Diagnosis and Management of Periorbital Atypical Pigmented Skin Lesions.
J Clin Med
August 2024
Department of Ophthalmology, University of Catania, 95123 Catania, Italy.
Article Synopsis
- Lentigo maligna (LM) and lentigo maligna melanoma (LMM) are key melanoma subtypes with an incidence of 1.37 per 100,000 in the U.S., often misdiagnosed, especially among the elderly, leading to treatment delays.
- A study evaluated the diagnostic abilities of ophthalmologists in identifying pigmented skin lesions in the periorbital region by reviewing 79 cases, comparing their results with dermatologists.
- Results showed that ophthalmologists had a diagnostic accuracy of 63.5% and lower sensitivity compared to dermatologists (33.3% vs. 46.9%), with a significantly higher percentage of ophthalmologists rating cases as "difficult" and suggesting fewer biopsies
Pediatric Cancer Screening in Hereditary Gastrointestinal Cancer Risk Syndromes: An Update from the AACR Childhood Cancer Predisposition Working Group.
Clin Cancer Res
October 2024
Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas.
Article Synopsis
- Pediatric patients with gastrointestinal (GI) polyposis and cancer often have hereditary cancer risk syndromes that necessitate ongoing cancer screening.
- Recognizing at-risk individuals through family history and clinical features aids in effective cancer risk assessment and management from childhood onward.
- The 2024 updates to hereditary GI cancer screening guidelines emphasize collaboration between pediatric and adult gastroenterology to enhance management practices, focusing on conditions like familial adenomatous polyposis, Peutz-Jeghers syndrome, and juvenile polyposis syndrome.