Bioorthogonal chemistry of polyoxometalates - challenges and prospects.

Bioorthogonal chemistry has enabled scientists to carry out controlled chemical processes in high yields while minimizing hazardous effects. Its extension to the field of polyoxometalates (POMs) could open up new possibilities and new applications in molecular electronics, sensing and catalysis, including inside living cells. However, this comes with many challenges that need to be addressed to effectively implement and exploit bioorthogonal reactions in the chemistry of POMs.