Model-Based Nanoengineered Pharmacokinetics of Iron-Doped Copper Oxide for Nanomedical Applications.

The progress in nanomedicine (NM) using nanoparticles (NPs) is mainly based on drug carriers for the delivery of classical chemotherapeutics. As low NM delivery rates limit therapeutic efficacy, an entirely different approach was investigated. A homologous series of engineered CuO NPs was designed for dual purposes (carrier and drug) with a direct chemical composition-biological functionality relationship.

Microstructure Adjustment of Spherical Micro-samples for High-Throughput Analysis Using a Drop-on-Demand Droplet Generator.

High-throughput methods for the development of structural materials require samples which are comparable in geometric dimensions and microstructure. Molten metal droplet generators produce thousands of droplets and microspheres from specific alloys with very good reproducibility. In this study, droplet generation experiments were conducted with two alloys and their microstructure was analyzed regarding secondary dendrite arm spacing (SDAS) in order to determine cooling rates during solidification.

Parameter Optimization in High-Throughput Testing for Structural Materials.

High-throughput screenings are established evaluation methods in the development of functional materials and pharmaceutical active ingredients. The transfer of this approach to the development of structural materials requires extensive adaptations. In addition to the investigation of new test procedures for the determination of material properties and the treatment of metallic materials, the design of experiments is a research focus.

A High Temperature Drop-On-Demand Droplet Generator for Metallic Melts.

In this study we present the design and functionality of a pneumatic drop-on-demand droplet generator that produces metallic micro particles with a size range of 300 µm to 1350 µm at high temperatures of up to 1600 °C. Molten metal droplets were generated from an EN 1.3505 (AISI 52100) steel which solidified during a falling distance of 6.

Asymmetrical Double Flame Spray Pyrolysis-Designed SiO/CeZrO for the Dry Reforming of Methane.

Silica has the potential to enhance the performance of ceria-zirconia as a support for the dry reforming of methane; however, controlling the integration of silica with the ceria-zirconia using flame spray pyrolysis (FSP) is a significant challenge. To address this challenge, an asymmetrically variable double-FSP (DFSP) system was established to control the SiO interaction with CeZrO. The engineered materials were then utilized as supports for Ni for the dry reforming of methane.

Analysis of the Downscaling Effect and Definition of the Process Fingerprints in Micro Injection of Spiral Geometries.

Microinjection moulding has been developed to fulfil the needs of mass production of micro components in different fields. A challenge of this technology lies in the downscaling of micro components, which leads to faster solidification of the polymeric material and a narrower process window. Moreover, the small cavity dimensions represent a limit for process monitoring due to the inability to install in-cavity sensors.

Structuring of Bioceramics by Micro-Grinding for Dental Implant Applications.

Metallic implants were the only option for both medical and dental applications for decades. However, it has been reported that patients with metal implants can show allergic reactions. Consequently, technical ceramics have become an accessible material alternative due to their combination of biocompatibility and mechanical properties.

Influence of Process Fluctuations on Residual Stress Evolution in Rotary Swaging of Steel Tubes.

Infeed rotary swaging is a cold forming production technique to reduce the diameter of axisymmetric components. The forming is achieved discontinuously by a series of radial strokes that are spread over the shell of the part. Due to tolerances within the rotary swaging machine, these strokes perform individually and the resulting stroke pattern is not homogeneous with regards to circumferential and longitudinal distribution.

The impact of nanoparticle-driven lysosomal alkalinization on cellular functionality.

Background: The biomedical use of nanosized materials is rapidly gaining interest, which drives the quest to elucidate the behavior of nanoparticles (NPs) in a biological environment. Apart from causing direct cell death, NPs can affect cellular wellbeing through a wide range of more subtle processes that are often overlooked. Here, we aimed to study the effect of two biomedically interesting NP types on cellular wellbeing.

Conformational state and charge determine the interfacial stabilization process of beta-lactoglobulin at preoccupied interfaces.

Amphiphilic properties enable proteins like β-lactoglobulin to stabilize oil/water-interfaces and provide stability in food-related emulsions. During emulsification, the protein undergoes three stages: (I) migration through bulk phase, (II) adsorption, and (III) interfacial rearrangement at the oil/water-interface - the kinetics of which require further research. Therefore, the aim of our study was the analytical and computational investigation of stage (I) and (II) as a function of the interfacial preoccupation, conformational state and charge of β-lactoglobulin.

Electrochemical Behavior of Single CuO Nanoparticles: Implications for the Assessment of their Environmental Fate.

The electrochemical behavior of copper oxide nanoparticles is investigated at both the single particle and at the ensemble level in neutral aqueous solutions through the electrode-particle collision method and cyclic voltammetry, respectively. The influence of Cl and NO anions on the electrochemical processes occurring at the nanoparticles is further evaluated. The electroactivity of CuO nanoparticles is found to differ between the two types of experiments.

Optical Spectroscopy for Analysis and Monitoring of Metalworking Fluids.

For various industrial manufacturing processes, water-based metalworking fluids (MWFs) are of high relevance due to their cooling and lubricating ability. They commonly form oil-in-water emulsions or solutions and hence their composition and stability is crucial for their performance in the metalworking process. To ensure a long service life of the MWF, intense monitoring is obligatory.