Age-related hearing loss: how to screen for it, and when to intervene.

Hearing loss is prevalent among older adults and is associated with depression, cognitive decline, reduction in functional status, and emotional and social handicaps. Screening by physicians is important, because older adults tend to underestimate the degree of their hearing impairment. The most important predictor of hearing aid candidacy is not the severity of hearing loss but rather the patient's motivation and perception of the handicapping effects of his/her hearing impairment.

Irreversible inhibition of a monoclonal antibody by a nitrophenyl ester.

TEPC-15 is a phosphorylcholine-binding mouse myeloma protein which reacts with an ester-containing phosphorylcholine, the p-nitrophenyl ester of 6-(phosphorylcholine)hexanoic acid (PEPCH). The rate of nitrophenolate release mediated by the antibody is pH-dependent and increases with increasing pH. The antibody becomes inactive during the reaction with the ester.

AIDS mortality among Puerto Ricans and other Hispanics in New York City, 1981-1987.

Analysis of AIDS mortality data for New York City for 1981-1987 reveals that Puerto Ricans represent the racial/ethnic group most severely affected by this city's AIDS epidemic. Cumulative age-adjusted AIDS mortality rates among Puerto Rico-born males are significantly higher (362 per 100,000) than among blacks (267), whites (182), or other Hispanic (217) males, and cumulative age-specific mortality rates for males are highest for the Puerto Rico-born in every adult age group. AIDS proportional mortality analysis indicates that in 1987 the proportion of all deaths due to AIDS was 10% among those Puerto Rican-born, 12% among other Hispanics (which includes at least 50% United States-born Puerto Ricans), 6% among blacks, and 2% among whites.