1,907 results match your criteria: "Lehigh Valley Hospital & Health Network[Affiliation]"

RNA in cardiovascular disease: A new frontier of personalized medicine.

Prog Cardiovasc Dis

August 2024

Department of Cardiology, Ochsner Clinic Foundation, New Orleans, LA, United States; The University of Queensland Medical School, Ochsner Clinical School, New Orleans, LA, United States.

Article Synopsis
  • Personalized medicine is advancing with RNA therapy, providing new treatment options for cardiovascular diseases (CVD) by targeting the human genome.
  • Current research shows promise in using RNA therapies for diagnosing and preventing heart-related conditions, but only a few treatments are in clinical trials or FDA-approved.
  • Key challenges include delivering drugs effectively to cells, managing immune responses, and ensuring overall safety, which need to be addressed for RNA therapies to progress.
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Objectives: Galectin-3 is a beta-galactoside-binding lectin and is a marker of cardiovascular disease (CVD) in the general population. It may also play a role in joint inflammation. We asked whether serum galectin-3 is a useful marker of subclinical vascular disease in patients with rheumatoid arthritis (RA).

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Article Synopsis
  • The review highlights the challenges of managing antithrombotic therapy for atrial fibrillation (AF) patients undergoing percutaneous coronary intervention (PCI), emphasizing the need to balance the prevention of ischemic events and minimizing bleeding risks.
  • It spans research from 2010 to October 2023 and calls for personalized treatment strategies to optimize antithrombotic therapy in these patients.
  • The expert opinion favors double antithrombotic therapy (DAT) over triple therapy (TAT) for better safety without compromising effectiveness, recommending NOAC-based DAT post-PCI while addressing ongoing challenges in specific patient groups.
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Introduction: Subsidence is a relatively common consequence after anterior cervical discectomy and fusion (ACDF) surgery. This study aimed to identify the effect of radiological and non-radiological risk factors on subsidence after a single-level ACDF surgery with cage and plate.

Methods: This is a retrospective cohort study of patients who underwent ACDF for radiculopathy or myelopathy at an academic center, University of Kentucky Albert Chandler Hospital, Lexington, Kentucky, United States, between January 2010 and January 2020.

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Article Synopsis
  • The study aimed to evaluate the effectiveness of the IABP-SHOCK II risk score in predicting in-hospital mortality in cardiogenic shock (CS) patients from a North American cohort, comparing its performance to its original European context.
  • The analysis included 5,340 admissions for CS across 35 medical centers, revealing that the IABP-SHOCK II score effectively identified different risk levels of mortality in both AMI-related and non-AMI-related CS patients.
  • Overall, while the risk score demonstrated some predictive capability for in-hospital mortality in various CS types, its correlation with other mortality assessment tools was only moderate, indicating room for improvement in risk stratification methods.
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Intracardiac Thrombus in COVID-19 Inpatients: A Nationwide Study of Incidence, Predictors, and Outcomes.

Angiology

January 2024

Department of Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.

COronaVIrus Disease-2019 (COVID-19) is associated with a hypercoagulable state. Intracardiac thrombosis is a potentially serious complication but has seldom been evaluated in COVID-19 patients. We assessed the incidence, associated factors, and outcomes of COVID-19 patients with intracardiac thrombosis.

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Women and Authorship in Medical Toxicology: Canaries in the Coal Mine.

J Med Toxicol

January 2024

Department of Emergency and Hospital Medicine, Lehigh Valley Health Network/USF Morsani College of Medicine, 2545 Schoenersville Road, 5th Floor, South Building, Bethlehem, PA, 18017, USA.

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Objective: Brain arteriovenous malformations (AVMs) present significant challenges in neurosurgery, requiring detailed planning and execution. In this study, the authors aimed to evaluate the efficacy of mixed reality (MxR), a synergistic application of virtual reality (VR) and augmented reality (AR), in the surgical management of AVMs.

Methods: A retrospective review was conducted on 10 patients who underwent AVM resection between 2021 and 2023.

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Article Synopsis
  • * A study involving 26 medical professionals assessed how consistently they evaluated sepsis risk and discovered significant variations in their judgments, with agreement around clinical actions improving when they reflected on their own cases.
  • * The findings suggest that implementing a new host response sepsis test could enhance the accuracy of sepsis diagnosis and should be standardized to improve overall patient care.
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Background: There has been debate on the use of intravenous thrombolysis (IVT) in patients with ischemic stroke and the recent use of direct oral anticoagulants (DOACs). Studies have compared these patients with non-DOAC groups in terms of outcomes. Herein, we aimed to systematically investigate the association between DOAC use and IVT's efficacy and safety outcomes.

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Alopecia Universalis Treated With Tofacitinib: The Role of JAK/STAT Inhibitors in Hair Regrowth.

Cutis

November 2023

Dr. Schwartzberg is from the Department of Medicine, Lehigh Valley Health Network, Allentown, Pennsylvania. Dr. Spizuoco is from True Dermatology PLLC, New York, New York, and the Department of Dermatology, Mount Sinai Beth Israel Hospital, New York.

Alopecia universalis is alopecia areata (AA) with total-body involvement of hair loss. The disease progression is due to autoimmune T cells. We present a case of a patient with alopecia universalis who was successfully treated with tofacitinib.

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Article Synopsis
  • In acute myeloid leukemia (AML), the interactions between donor KIR and recipient HLA may affect the effectiveness of stem cell transplants, but findings on their impact have been inconsistent, particularly in matched unrelated donor scenarios.
  • A study involving 2025 AML patients found specific KIR/HLA pairs, notably donor-2DL2+/recipient-HLA-C1+, associated with lower relapse rates, while certain KIR genotypes showed a mix of benefits and risks related to relapse.
  • Ultimately, the research did not yield conclusive evidence to support KIR-based strategies for selecting donors in AML, as results were not validated in a separate patient cohort.
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Background: Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) is associated with significant morbidity and mortality. Mechanical circulatory support (MCS) devices increase systemic blood pressure and end organ perfusion while reducing cardiac filling pressures.

Methods And Results: The National Cardiogenic Shock Initiative (NCT03677180) is a single-arm, multicenter study.

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  • This study aimed to assess how many patients with rheumatoid arthritis (RA) can maintain remission or low disease activity (LDA) after stopping tumor necrosis factor inhibitors (TNFi), looking at both induction and maintenance treatments.
  • A systematic review of studies from 2005 to May 2022 found that around 58% of patients in induction studies and about 48% in maintenance studies remained in remission or LDA 37-52 weeks post-discontinuation.
  • The research indicated that while many patients can successfully stop TNFi, those with a longer duration of RA are less likely to maintain remission after discontinuation.
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Developing an International Framework for Informed Consent in Plastic Surgery: A Focus on Cosmetic Breast Augmentation.

Plast Reconstr Surg Glob Open

November 2023

International Confederation of Plastic Surgery Societies, Arlington Heights, Ill.

Background: Informed consent is a fundamental pillar of patient rights and is an essential part of good clinical practice. In 2019, the International Confederation of Plastic Surgery Societies launched a survey to collect feedback on informed consent practices, with an aim to develop an international guideline for cosmetic surgery.

Methods: A 15-question survey was sent to delegates of the International Confederation of Plastic Surgery Societies for dissemination to their national society members.

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Coronary bifurcation lesions are frequent challenging findings during percutaneous coronary intervention (PCI). Contemporary evidence has explored the potential sex-specific differences in patients undergoing PCI. In the present meta-analysis, we compared clinical outcomes of patients undergoing bifurcation PCI between women and men.

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The impact of air quality on cardiovascular health: A state of the art review.

Curr Probl Cardiol

February 2024

Department of Cardiology, Lehigh Valley Health Network, Allentown, PA, USA. Electronic address:

Air pollution is a global health challenge, increasing the risk of cardiovascular diseases such as heart disease, stroke, and arrhythmias. Particulate matter (PM), particularly PM2.5 and ultrafine particles (UFP), is a key contributor to the adverse effects of air pollution on cardiovascular health.

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Importance: Among patients receiving mechanical ventilation, tidal volumes with each breath are often constant or similar. This may lead to ventilator-induced lung injury by altering or depleting surfactant. The role of sigh breaths in reducing ventilator-induced lung injury among trauma patients at risk of poor outcomes is unknown.

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Background In the United States, homelessness is an issue that may affect a significant portion of the adolescent population. There is no consensus on the extent to which this population has been impacted by poor mental health and lack of resources. This study aimed to characterize trends among those who struggle with housing insecurity and mental illness to provide a clearer picture of mental health needs among this population.

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