Polysaccharide from Helianthus tuberosus L. as a potential radioprotector.

Introduction: Radioprotectors help to protect the body or at least minimize the negative consequences of radiation exposure. The present study aimed to assess the radioprotective potential of Helianthus tuberosus L. polysaccharide (HTLP) in vitality and micronuclei tests.

Study of Radiosensitivity and Induction of Radiation Adaptive Response in Peripheral Blood Lymphocytes of Patients with Oncological Diseases Using the Micronuclear Test.

Radiosensitivity to low and medium doses of X-ray radiation and the ability to induce a radiation adaptive response (RAR) of lymphocytes during in vitro irradiation of peripheral blood of patients with cancer were studied. The criterion for cytogenetic damage was the frequency of micronuclei (MN) in cytochalasin-blocked binucleate lymphocytes in culture. It was found that the spontaneous level of cytogenetic damage in the lymphocytes of patients was 2.

Shock-ignition effect in indirect-drive inertial confinement fusion approach.

Shock-ignition effect in indirect-drive thermonuclear target is demonstrated on the base of numerical simulations. Thermonuclear gain (in relation to laser pulse energy) of a shock-ignited indirect-drive thermonuclear capsule is obtained, which is 22.5 times higher than that at a traditional spark ignition of the capsule with the same DT-fuel mass, wherein the shock-ignition laser pulse energy is 1.

Interactions of peroxy radicals from monoterpene and isoprene oxidation simulated in the radical volatility basis set.

Isoprene affects new particle formation rates in environments and experiments also containing monoterpenes. For the most part, isoprene reduces particle formation rates, but the reason is debated. It is proposed that due to its fast reaction with OH, isoprene may compete with larger monoterpenes for oxidants.

Multi-Wavelength Raman Differentiation of Malignant Skin Neoplasms.

Raman microspectroscopy has become an effective method for analyzing the molecular appearance of biomarkers in skin tissue. For the first time, we acquired in vitro Raman spectra of healthy and malignant skin tissues, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), at 532 and 785 nm laser excitation wavelengths in the wavenumber ranges of 900-1800 cm and 2800-3100 cm and analyzed them to find spectral features for differentiation between the three classes of the samples. The intensity ratios of the bands at 1268, 1336, and 1445 cm appeared to be the most reliable criteria for the three-class differentiation at 532 nm excitation, whereas the bands from the higher wavenumber region (2850, 2880, and 2930 cm) were a robust measure of the increased protein/lipid ratio in the tumors at both excitation wavelengths.

Mutual Transformations of Polysulfide Chromophore Species in Sodalite-Group Minerals: A DFT Study on S Decomposition.

It is known that various polysulfide species determine the color of sodalite-group minerals (haüyne, lazurite, and slyudyankaite), and that heating induces their transformations and color change, but the mechanisms of the transitions are unknown. A prominent example is the decay of cyclic S molecule. Using density-functional simulations, we explore its main decay pathways into the most probable final reaction products (the pairs of radical anions S⋅+S⋅ and S⋅+S⋅).

Even and Odd Cat States of Two and Three Qubits in the Probability Representation of Quantum Mechanics.

We derive the probability representation of even and odd cat states of two and three qubits. These states are even and odd superpositions of spin-1/2 eigenstates corresponding to two opposite directions along the axis. The probability representation of even and odd cat states of an oscillating spin-1/2 particle is also discussed.

Strong diffraction effects accompany the transmission of a laser beam through inhomogeneous plasma microstructures.

In the study we thoroughly analyze diffraction effects accompanying the laser beam transmission through inhomogeneous plasma microstructures and simulate their diffraction patterns at the object output and in the near field. For this we solve the scalar Helmholtz wave equation in the first Rytov approximation and compute the diffraction spreading of the transmitted beam in free space. Diffraction effects are found to arise within the beam passage through inhomogeneous plasma microstructures even in the simplest approximations of the laser beam interaction with plasma.

Fluorescence saturation imaging microscopy: molecular fingerprinting with a standard confocal microscope.

Molecular specificity in fluorescence imaging of cells and tissues can be increased by measuring parameters other than intensity. For instance, fluorescence lifetime imaging became a widespread modality for biomedical optics. Previously, we suggested using the fluorescence saturation effect at pulsed laser excitation to map the absorption cross-section as an additional molecular contrast in two-photon microscopy [Opt.

Quinoxaline-based azamacrocycles: synthesis, AIE behavior and acidochromism.

The development of luminescent molecular materials has advanced rapidly in recent decades, primarily driven by the synthesis of novel emissive compounds and a deeper understanding of excited-state mechanisms. Herein, we report a streamlined synthetic approach to light-emitting diazapolyoxa- and polyazamacrocycles NCOQ and NCQ ( = 3-10; = 2, 3; = 2-5), incorporating a 2,3-diphenylquinoxaline residue (DPQ). This synthetic strategy based on macrocyclization through Pd-catalyzed amination reaction yields the target macrocycles in good or high yields (46-92%), enabling precise control over their structural parameters.

A Set of New Promising Solid Chalcogenides for Na-Ion Batteries: Yield from the Crystal Chemical, Monte-Carlo and Quantum-Chemical Calculations.

Free crystal space in more than 600 chalcogenide structures taken out from the ICSD has been theoretically analyzed. As a result, wide voids and channels accessible for Na-ion migration were found in 236 structures. Among them, 165 compounds have not been described in the literature as Na-conducting materials.

Binary Proton Therapy of Ehrlich Carcinoma Using Targeted Gold Nanoparticles.

Proton therapy can treat tumors located in radiation-sensitive tissues. This article demonstrates the possibility of enhancing the proton therapy with targeted gold nanoparticles that selectively recognize tumor cells. Au-PEG nanoparticles at concentrations above 25 mg/L and 4 Gy proton dose caused complete death of EMT6/P cells in vitro.

Studies of Fractal Microstructure in Nanocarbon Polymer Composites.

The in situ study of fractal microstructure in nanocarbon polymers is an actual task for their application and for the improvement in their functional properties. This article presents a visualization of the bulk structural features of the composites using pulsed acoustic microscopy and synchrotron X-ray microtomography. This article presents details of fractal structure formation using carbon particles of different sizes and shapes-exfoliated graphite, carbon platelets and nanotubes.

Deceleration of fast ion rarefied beam due to Cherenkov interaction with ion-acoustic waves.

The deceleration of a low-density beam of ions in plasma with developed ion-acoustic turbulence arising in strong electric field is described. The time and length of beam deceleration along and across the anisotropy axis of the wave number distribution of ion-acoustic waves are found. It is shown to what extent an increase in the strength of the electric field that generates turbulence is accompanied by a decrease in the time and length of braking.

Predicting Diffusion Coefficients in Nafion Membranes during the Soaking Process Using a Machine Learning Approach.

Nafion, a versatile polymer used in electrochemistry and membrane technologies, exhibits complex behaviors in saline environments. This study explores Nafion membrane's IR spectra during soaking and subsequent drying processes in salt solutions at various concentrations. Utilizing the principles of Fick's second law, diffusion coefficients for these processes are derived via exponential approximation.

Excited States in Single-Stranded and i-Motif DNA with Silver Ions.

We have studied the excited states and structural properties for the complexes of cytosine (dC) chains with silver ions (Ag) in a wide range of the Ag to DNA ratio () and pH conditions using circular dichroism, steady-state absorption, and fluorescence spectroscopy along with the ultrafast fluorescence upconversion technique. We also calculated vertical electronic transition energies and determined the nature of the corresponding excited states in some models of the cytosine-Ag complexes. We show that (dC) chains in the presence of silver ions form a duplex stabilized by C-Ag-C bonds.

From a humorous post to a detailed quantum-chemical study: isocyanate synthesis revisited.

Isocyanates play an essential role in modern manufacturing processes, especially in polyurethane production. There are numerous synthesis strategies for isocyanates both under industrial and laboratory conditions, which do not prevent searching for alternative highly efficient synthetic protocols. Here, we report a detailed theoretical investigation of the mechanism of sulfur dioxide-catalyzed rearrangement of phenylnitrile oxide into phenyl isocyanate, which was first reported in 1977.

High-magnification Faraday rotation imaging and analysis of X-pinch implosion dynamics.

An X-pinch load driven by an intense current pulse (>100 kA in ∼100 ns) can result in the formation of a small radius, runaway compressional micro-pinch. A micro-pinch is characterized by a hot (>1 keV), current-driven (>100 kA), high-density plasma column (near solid density) with a small neck diameter (1-10 µm), a short axial extent (<1 mm), and a short duration (≲1 ns). With material pressures often well into the multi-Mbar regime, a micro-pinch plasma often radiates an intense, sub-ns burst of sub-keV to multi-keV x rays.

Electromagnetic and gravitational radiation of blazar OJ 287.

Based on long-term monitoring data of the blazar, a new model for determining the parameters of this close binary supermassive black hole (SMBH) is proposed. The model uses the laws of celestial mechanics and results of harmonic analysis of observational data obtained mainly in the radio and optical wavelength ranges. Within the framework of the proposed model, the masses of SMBH companions, the values of their orbital elements, the parameters of the accretion disk, and its dimensions and thickness were determined.

Not All Probability Density Functions Are Tomograms.

This paper delves into the significance of the tomographic probability density function (pdf) representation of quantum states, shedding light on the special classes of pdfs that can be tomograms. Instead of using wave functions or density operators on Hilbert spaces, tomograms, which are the true pdfs, are used to completely describe the states of quantum systems. Unlike quasi-pdfs, like the Wigner function, tomograms can be analysed using all the tools of classical probability theory for pdf estimation, which can allow a better quality of state reconstruction.

Characterization of the fiber-like cortical cells in moss gametophytes.

Fiber-like cells with thickened cell walls of specific structure and polymer composition that includes (1 → 4)-β-galactans develop in the outer stem cortex of several moss species gametophytes. The early land plants evolved several specialized cell types and tissues that did not exist in their aquatic ancestors. Of these, water-conducting elements and reproductive organs have received most of the research attention.

Cytotoxicity of Laser-Synthesized Nanoparticles of Elemental Bismuth.

High X-ray absorption combined with photothermal properties make bismuth nanoparticles (Bi NP) a promising agent for multimodal cancer theranostics. However, the synthesis of Bi NP by the "classical" chemical methods has numerous limitations, including potential toxicity of the produced nanomaterials. Here we studied in vitro toxicity of laser-synthesized Bi NP coated with Pluronic F-127 on mouse fibroblast cell line L929.