Anti-Inflammatory and Antioxidant Effects of Aqueous Extract on the Liver and Kidney of PCOS Mice.

Background: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder associated with increased risk of kidney and liver damage. Current treatments have shown contradictory outcomes, and their long-term use causes unwanted side effects. could serve as a complementary medicine to current PCOS treatments.

Health-related physical fitness in children among five Mediterranean countries: a cross-cultural study from the DELICIOUS project.

Background: Health-related fitness (HRF) components are essential for supporting healthy growth and reducing long-term health risks in children. This study explored cross-cultural variations in HRF among children from five Mediterranean countries-Egypt, Italy, Lebanon, Portugal, and Spain-within the framework of the DELICIOUS project.

Methods: A total of 860 children participated in the study, including 204 from Egypt ( = 204, 11.

Influenza vaccine hesitancy and its determinants among Lebanese public transportation drivers.

Introduction: According to the National Institute for Occupational Safety and Health, ensuring influenza vaccination for public transportation drivers is considered a public health objective, given that these drivers are at high risk of contracting influenza. The main purpose of this cross-sectional study is, thus, to evaluate influenza vaccine hesitancy (VH) and its determinants among a representative sample of Lebanese public transportation drivers.

Methods: A survey questionnaire is conducted between January and March 2023, with the participation of a proportionate purposeful sample of 509 drivers from various regions in Lebanon.

Association between the Taq1A polymorphism and problematic media use in preadolescent children.

Objective: Problematic media use (PMU) is addiction-like media use. No study has examined if genetic factors for addiction relate to PMU during childhood. This study tested the association between genetic risk factors for addiction and PMU among 9-to-12-year-olds.

Emerging contaminants in the Mediterranean Sea endangering Lebanon's Palm Islands Natural Reserve.

The Mediterranean Sea is an intercontinental marine environment renowned for its biodiversity and ecological significance. However, it is also one of the most polluted seas globally with significant levels of microplastics and heavy metals among other emerging contaminants. In Lebanon, inadequate waste management infrastructure and unregulated industrial discharges have exacerbated water quality deterioration by introducing these complex contaminants into surface and seawater.

Defying the Odds: A Case of Successfully Treated Harlequin Ichthyosis in Lebanon.

Harlequin ichthyosis is a rare skin disorder affecting newborns characterized by a scaly skin, flexed limbs, ectropium, and eclabium. The overall incidence of HI is 1 in 300,000 births, with approximately only 200 cases reported worldwide. Some studies uncovered a TH17 immune skewing in patients with HI, which is also seen in psoriasis.

Lessons From Implementing Research-Supported Practices to Address Psychiatric Illnesses in Two Countries.

Across the globe, psychiatric illnesses are common, painful, often disabling, and sometimes deadly. Although well-researched practices exist to address these disorders, most people with psychiatric illnesses do not have access to care that has been demonstrated to be effective. Practical clinical leadership experience and engagement in evidence-based practice (EBP) implementation research in Colombia and the United States have demonstrated that multisite EBP implementation is possible and that effective implementation improves outcomes for people who develop psychiatric illnesses.

Exploring the Intersection of Gender Diversity and Intellectual Disability: A Scoping Review With a Focus on Clinical Care.

Background: Little research has been conducted solely exploring gender diversity in people with intellectual disabilities. This review explores the literature, discusses the prevalence, and identifies clinical best practices for people at the intersection of gender diversity and intellectual disability.

Method: A scoping review was conducted utilising PRISMA methodology of the following databases: PubMed, CINAHL Complete (EBSCO), Cochrane Library (Wiley), Dissertations & Theses Global (ProQuest), PsycInfo (EBSCO), Scopus and Web of Science.

Cost-effectiveness of watchful waiting versus immediate emergency department transfer after epinephrine autoinjector use in Canada.

Background: Until recently, immediate emergency department (ED) transfer after food-related anaphylactic reactions was recommended regardless of symptom resolution following use of an epinephrine autoinjector (EAI). We evaluated the cost-effectiveness of delayed ED transfer after EAI use in non-medical settings (watchful waiting) compared to immediate ED transfer among pediatric patients with food allergies in Canada.

Methods: We developed a probabilistic Markov model of individuals starting at age of one year who are at risk of severe food-related allergic reactions requiring epinephrine.

Burden of pertussis in infants in the Eastern Mediterranean Region and the impact of maternal vaccination: a systematic review.

Background: Despite vaccine availability, Pertussis remains a global public health challenge, especially among infants. The Eastern Mediterranean Region (EMR) presents a diverse epidemiological landscape with varying vaccination coverages and healthcare infrastructures. This systematic review aimed to assess the burden of pertussis in infants < 1 year of age in the EMR and evaluate the use and impact of pertussis vaccination during pregnancy.

Satiety: a gut-brain-relationship.

Many hormones act on the hypothalamus to control hunger and satiety through various pathways closely associated with several factors. When food is present in the gastro intestinal (GI) tract, enteroendocrine cells (EECs) emit satiety signals such as cholecystokinin (CCK), glucagon like peptide-1 (GLP-1) and peptide YY (PYY), which can then communicate with the vagus nerve to control food intake. More specifically, satiety has been shown to be particularly affected by the GLP-1 hormone and its receptor agonists that have lately been acknowledged as a promising way to reduce weight.

A comparison of objective and subjective measures of physical activity, sedentary and sleep behaviors between persons with and without depressive symptoms.

Background: Major Depressive Disorder (MDD) is characterized by negative recall biases, which may impact how individuals with depressive symptoms report physical activity (PA), sedentary, and sleep behaviors. Additionally, there are discrepancies between subjective and objective behaviors in MDD. Thus, the current study investigated whether individuals with depressive symptoms differ in their subjective and objective PA, sedentary, and sleep behaviors, and whether the magnitude of these discrepancies differ from those in individuals without depressive symptoms.

Exploring risk factors and antimicrobial susceptibility patterns associated with bacteriuria among Syrian refugees in makeshift camps.

Background: The health and well-being of refugees are critically compromised by harsh living conditions, which foster the emergence of infectious diseases and the misuse of antimicrobial agents. This multicentre cross-sectional community-based study investigated the prevalence of urine carriage of bacteria and the associated antimicrobial resistance patterns among Syrian refugees living in makeshift camps in Lebanon, an East Mediterranean country.

Methods: We used multivariable logistic regression models to identify the risk factors associated with bacteriuria in this vulnerable population.

Treatment of vision-threatening branch retinal artery occlusion following coronary angioplasty with surgical displacement of embolus.

Purpose: To report a successful case of vision restoration and macular reperfusion following branch retinal artery occlusion (BRAO) using pars plana vitrectomy with undermining the artery off the retinal bed.

Methods: This case report involves a 75-year-old patient who was diagnosed immediately with BRAO following cardiac catheterization procedure. An embolus at the superior retinal artery bifurcation was noted.

Life satisfaction around the world: Measurement invariance of the Satisfaction With Life Scale (SWLS) across 65 nations, 40 languages, gender identities, and age groups.

The Satisfaction With Life Scale (SWLS) is a widely used self-report measure of subjective well-being, but studies of its measurement invariance across a large number of nations remain limited. Here, we utilised the Body Image in Nature (BINS) dataset-with data collected between 2020 and 2022 -to assess measurement invariance of the SWLS across 65 nations, 40 languages, gender identities, and age groups (N = 56,968). All participants completed the SWLS under largely uniform conditions.

A Comprehensive Systematic Review and Meta-Analysis on the Prevalence of Aflatoxin M1 in Dairy Products in Selected Middle East Countries.

Background: Human consumption of dairy products contaminated with aflatoxin (AF) M1 can lead to severe health issues. This AF's significance and impact on health necessitate a thorough investigation of its prevalence in dairy products.

Objectives: This study aims to determine the prevalence of AFM1 in dairy products through a systematic review and meta-analysis, focusing on data from Middle Eastern countries.

Dementia incidence among a cohort of lebanese older adults: first incidence estimates from the Middle East and North Africa region.

Objective: To provide the first estimates of dementia incidence rates among elderly in Lebanon.

Methods: The cohort established in 2013 consisted of 470 elderly from Beirut and Mount Lebanon, who consented to be followed-up. In 2017, we reached 341 participants/informants, achieving a response rate of 72.

Reconstruction of Back Defect from Giant Congenital Melanocytic Nevus Using Dermal Substitute Matrix.

Giant congenital melanocytic nevi are large pigmented premalignant lesions present at birth that have an associated risk of malignant transformation. Full-thickness excision of these lesions would be required to eliminate this risk. However, giant nevi can leave behind large defects that can be challenging to reconstruct.

Examining the integration of refugees into the national health system in Uganda: an analysis using the policy triangle framework.

Background: Uganda has been confronted with a sustained influx of refugees for decades. This prompted the government to explore opportunities to integrate refugees into local service structures including its national health system. This paper chronicles the history of policies and strategies that have influenced the integration of refugees into the national health system in Uganda and investigates factors that impacted policy evolution and progression.

Infant and young child feeding practice status and its determinants in UAE: results from the MISC cohort.

Background: To evaluate breastfeeding and complementary feeding practices and their determinants among infants and young children in the United Arab Emirates using the 2021 WHO/UNICEF IYCF guidelines.

Methods: The Mother and Infant Study Cohort (MISC), is a prospective study of mothers recruited in their third gestational trimester and followed with their infants up to 18 months of age (n = 167). Data were collected at 3rd trimester, delivery, 2, 6, 12, and 18 months postpartum via questionnaires, review of medical records, anthropometric measurements, and 24-hour dietary recalls of the child's intake at 6, 12, and 18 months.

Coronin1A regulates the trafficking of alpha synuclein in microglia.

Microglia respond to cytotoxic protein aggregates associated with the progression of neurodegenerative disease. Pathological protein aggregates activate the microglial NLRP3 inflammasome resulting in proinflammatory signaling, secretion, and potentially pyroptotic cell death. We characterized mixed sex primary mouse microglia exposed to microbial stressors and alpha synuclein preformed fibrils (αsyn PFFs) to identify cellular mechanisms related to Parkinson's disease.

Radiation Exposure Analysis on 274 Patients With Vertebral Augmentation Using the Surgivisio Intraoperative Navigation System.

Background: Surgeons' reliance on intraoperative fluoroscopy during vertebroplasty procedures has raised concerns regarding the level of patient and surgeon radiation. Navigation systems have shown a potential to reduce the overall patient and medical staff exposure during dose exposure studies. The main objective of this study was to determine whether the Surgivisio platform (eCential Robotics, France), a unified imaging and navigation platform, lowers the patient dose during routine clinical usage as compared with published fluoroscopy and other navigation options that are published in the literature.

Can household energy efficiency dampen crude oil price volatility in the United States?

Even though the effect of oil price shocks on macroeconomics has been extensively investigated, the literature on how efficiency in household energy use affect crude oil price volatility is yet explored. This study unveils whether household energy efficiency lower crude oil price volatility asymmetrically in the United States using the historical and forecast dataset that spans from 1970:Q1-2040:Q1. Applying the multivariate case of Quantile-on-Quantile Regression, the empirical results show that household energy efficiency dampens crude oil price volatility with a stronger connection in quantiles before the median quantiles of crude oil price volatility.

Increased rate of multidrug-resistant gram-negative bacterial infections in hospitalized immunocompromised pediatric patients.

Introduction: Multidrug resistant Gram-negative bacterial infections are considered a major public health threat. Immunocompromised pediatric patients are at a great risk of severe or overwhelming infections. The aim of this study was to describe the frequency of infections with multidrug resistant (MDR) Gram-negative bacteria (GNB) in immunocompromised pediatric patients and to determine the risk factors.

Alopecia Management Potential of Rosemary-Based Nanoemulgel Loaded with Metformin: Approach Combining Active Essential Oil and Repurposed Drug.

Introduction: Androgenetic alopecia (AGA) is a multifactorial and age-related dermatological disease that affects both males and females, usually at older ages. Traditional hair repair drugs exemplified by minoxidil have limitations such as skin irritation and hypertrichosis. Thus, attention has been shifted to the use of repurposing drugs.