5 results match your criteria: "Le Bonheur Children's HospitalMemphis[Affiliation]"

Altered Rich-Club and Frequency-Dependent Subnetwork Organization in Mild Traumatic Brain Injury: A MEG Resting-State Study.

Front Hum Neurosci

August 2017

Biomedical Imaging Lab, Departments of Engineering Technology, Computer Science, Biomedical Engineering, and Electrical and Computer Engineering, University of HoustonHouston, TX, United States.

Functional brain connectivity networks exhibit "small-world" characteristics and some of these networks follow a "rich-club" organization, whereby a few nodes of high connectivity (hubs) tend to connect more densely among themselves than to nodes of lower connectivity. The Current study followed an "attack strategy" to compare the rich-club and small-world network organization models using Magnetoencephalographic (MEG) recordings from mild traumatic brain injury (mTBI) patients and neurologically healthy controls to identify the topology that describes the underlying intrinsic brain network organization. We hypothesized that the reduction in global efficiency caused by an attack targeting a model's hubs would reveal the "true" underlying topological organization.

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Though fairly well-studied in adults, less is known about the manifestation of resting state networks (RSN) in children. We examined the validity of RSN derived in an ethnically diverse group of typically developing 6- to 7-year-old children. We hypothesized that the RSNs in young children would be robust and would reliably show significant concordance with previously published RSN in adults.

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Article Synopsis
  • Chromosome 15q11-q13.1 duplication is a common genetic variation linked to autism spectrum disorder (ASD), mostly inherited from the mother, and often results in ASD.* -
  • The study investigates a family with a unique maternal duplication and somatic mosaicism, where the mother shows mild ASD and has a rare case of unilateral renal carcinoma, along with congenital anomalies.* -
  • The research findings indicate that the mother has varying degrees of the duplication in different tissues and suggest a potential growth advantage linked to this specific duplication in her case, which may not apply broadly to others with the same genetic variation.*
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Greater Repertoire and Temporal Variability of Cross-Frequency Coupling (CFC) Modes in Resting-State Neuromagnetic Recordings among Children with Reading Difficulties.

Front Hum Neurosci

May 2016

Division of Clinical Neurosciences, Department of Pediatrics, University of Tennessee Health Science CenterMemphis, TN, USA; Le Bonheur Neuroscience Institute, Le Bonheur Children's HospitalMemphis, TN, USA.

Cross-frequency, phase-to-amplitude coupling (PAC) between neuronal oscillations at rest may serve as the substrate that supports information exchange between functionally specialized neuronal populations both within and between cortical regions. The study utilizes novel algorithms to identify prominent instantaneous modes of cross-frequency coupling and their temporal stability in resting state magnetoencephalography (MEG) data from 25 students experiencing severe reading difficulties (RD) and 27 age-matched non-impaired readers (NI). Phase coherence estimates were computed in order to identify the prominent mode of PAC interaction for each sensor, sensor pair, and pair of frequency bands (from δ to γ) at successive time windows of the continuous MEG record.

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