2,313 results match your criteria: "Lawrenceville; Georgia Trauma Commission D.A.; and Doctors Hospital C.H.F.[Affiliation]"

Article Synopsis
  • * Autologous conditioned serum (ACS) therapy uses a patient's own blood to produce growth factors and anti-inflammatory substances, showing significant promise in reducing pain and improving knee function in patients with OA, based on a review of 18 clinical studies.
  • * Findings indicate that ACS therapy can be as effective or better than conventional treatments like platelet-rich plasma and steroids, with minimal adverse effects reported and potential benefits for tissue repair and disease modification.
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Review of dose justifications for antibody-drug conjugate approvals from clinical pharmacology perspective: A focus on exposure-response analyses.

J Pharm Sci

December 2024

Pharmacokinetic Sciences, Biomedical Research, Novartis, East Hanover, NJ, 07936, USA. Electronic address:

Article Synopsis
  • - Antibody-drug conjugates (ADCs) offer targeted cancer treatment, improving drug effectiveness while reducing side effects, but they can still cause toxicities from unintended targeting and payload release.
  • - Optimizing dosing regimens for ADCs requires a careful risk-benefit analysis, with exposure-response (E-R) analysis being essential for finding the right dose while managing safety and efficacy.
  • - The article reviews E-R analyses for all 12 FDA-approved ADCs in the U.S., highlighting shared safety and efficacy metrics and discussing dose optimization strategies crucial for developing cancer therapies.
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Objective: To evaluate the effectiveness of 2 interventions for caregivers of patients with acquired brain injury (ABI) transitioning home after inpatient rehabilitation, to prepare them for the role of caregiving and reduce stress and depression.

Design: Controlled trial with participants randomly assigned to (1) usual care (UC), (2) clinician-delivered Problem-Solving Training (PST), or (3) peer-led Building Better Caregivers (BBC) training; both experimental interventions initiated during the inpatient rehabilitation stay, delivered virtually, of similar intensity (six 60-minute sessions), and focused on managing stress and building skills related to caregiving.

Setting: Nonprofit rehabilitation hospital specializing in care of persons with acquired brain and spinal cord injuries.

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Article Synopsis
  • Water scarcity in California is worsening due to drought, climate change, pollution, and population growth, particularly impacting drinking water in socially disadvantaged communities.
  • A study collected tap water samples from various regions, focusing on low-income areas with high breast cancer rates, analyzing a total of 251 organic and 32 inorganic contaminants.
  • Results revealed frequent mixtures of contaminants exceeding safety levels across all regions, underscoring the need for further research to link these exposures to health risks like breast cancer in vulnerable populations.
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Editorial: Interactions between bioactive food ingredients and intestinal microbiota, volume II.

Front Microbiol

September 2024

Department of Biological Sciences, School of Science and Technology, Georgia Gwinnett College, Lawrenceville, GA, United States.

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Platelet Lysate and Osteoarthritis of the Knee: A Review of Current Clinical Evidence.

Pain Ther

December 2024

Department of Trauma and Orthopaedic Surgery, Faculty of Medicine and Psychology, University La Sapienza, 00185, Rome, Italy.

Introduction: Osteoarthritis (OA) of the knee affects millions of people with sizable socioeconomic burden. Conventional treatment modalities are prioritized, turning to surgical intervention only when they have failed. However, these traditional modalities have shortcomings, only aiming to reduce pain rather than targeting the underlying pathophysiology.

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Research into the disequilibrium of microglial phenotypes has become an area of intense focus in neurodegenerative disease as a potential mechanism that contributes to chronic neuroinflammation and neuronal loss in Parkinson's disease (PD). There is growing evidence that neuroinflammation accompanies and may promote progression of alpha-synuclein (Asyn)-induced nigral dopaminergic (DA) degeneration. From a therapeutic perspective, development of immunomodulatory strategies that dampen overproduction of pro-inflammatory cytokines from chronically activated immune cells and induce a pro-phagocytic phenotype is expected to promote Asyn removal and protect vulnerable neurons.

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Article Synopsis
  • Heme is a crucial compound for cells, offering iron and potential uses in food and medicine, which was explored using a model cyanobacteria, sp. PCC6803, for its synthesis.
  • Researchers engineered sp. PCC6803 by modifying its heme synthesis pathway and optimizing culture conditions, leading to significant increases in heme production—up to 10.25 times more than the wild type.
  • The study highlights sp. PCC6803's potential as a microbial cell factory for producing heme efficiently, paving the way for future research and engineering targets in this area.
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Choosing ankle tourniquets in foot and ankle surgery: Beyond postoperative pain considerations.

World J Orthop

September 2024

Department of Orthopaedics and Regenerative Medicine, Future Biologics, Lawrenceville, GA 30043, United States.

This editorial critically explores the use of ankle thigh tourniquets in foot and ankle surgery based on a recent study that found no significant difference in postoperative pain between the two placement techniques. Despite these findings, we argue for the preferential use of ankle tourniquets, highlighting their potential benefits in reducing venous blood stasis and minimizing soft tissue injury. This approach underscores the importance of considering long-term patient outcomes and vascular health beyond immediate postoperative pain.

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Background: The minimal important difference (MID) is a useful tool to interpret changes in patients' health-related quality of life. This study aims to estimate MIDs for interpreting within-patient change for both components of the EQ-5D-5L questionnaire [EQ-Visual Analogue Scale (EQ-VAS) and utility index] and domains of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) for cancer patients.

Methods: Data were obtained from the Cancer 2015 dataset, a longitudinal cohort of Australian cancer patients.

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Article Synopsis
  • The study evaluates the Palmer algorithm, which aids in selecting flexible survival models for extrapolating long-term survival data from immuno-oncology trials.
  • The algorithm was applied to data from the CheckMate-649 trial, comparing survival estimates from various models against actual observed survival over 48 months.
  • Results showed that while the algorithm systematically identifies models, only certain flexible parametric models accurately predicted long-term survival, with recommendations for minor improvements to enhance its usability.
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At JADPRO Live 2023, presenters discussed the implications of biomarker testing, pivotal clinical trials leading to recent FDA approvals, and evidence-based best practices for monitoring and managing adverse events associated with molecular targeted and combination therapies for patients with metastatic non-small cell lung cancer.

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A primer on method effects on observed correlations with examples.

Int J Psychol

December 2024

Organizational Research & Development, University of the Western Cape, Lawrenceville, GA, USA.

I use a path/confirmatory factor analytic framework to present an under-the-hood introduction to (a) the effects of measurement error and method variance on observed measures, (b) the effects of common latent Trait and Method factors on relationships between observed measures in the presence of measurement error and (c) examine implications of developments presented here for the possible reinterpretation of Campbell and Fiske's original criteria for convergent and discrimainat validity and presence of common method bias. I use results from one previously published and often-cited primary study and four meta-analyses of multitrait-multimethod studies to provide empirical examples to illustrate points made here. I show analytically that (a) some common interpretations of method effects are correct, (b) others are incorrect and (c) still others are more nuanced than is usually recognised.

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Background: Psoriasis, a chronic, immune-mediated, inflammatory disease, affects 2‒3% of the population. Tyrosine kinase 2 (TYK2) mediates cytokine signaling involved in adaptive [interleukin (IL)-12, IL-23] and innate (type-I interferons) immune responses; IL-23-driven T-helper (Th)17 pathways play a key role in chronic inflammation in psoriasis. In a phase 2 trial, deucravacitinib, an oral, selective, allosteric TYK2 inhibitor, reduced IL-23/Th17 and type-I interferon pathway expression in the skin of patients with moderate to severe plaque psoriasis, reductions that were accompanied by clinical improvement of psoriatic lesions.

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Objective: The All of Us Evenings with Genetics (EwG) Research Program at Baylor College of Medicine (BCM), funded to engage research scholars to work with the All of Us data, developed a training curriculum for the Researcher Workbench, the platform to access and analyze All of Us data. All of Us EwG developed the curriculum so that it could teach scholars regardless of their skills and background in programming languages and cloud computing. All of Us EwG delivered this curriculum at the first annual All of Us EwG Faculty Summit in May 2022.

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Thermal transformations of perfluorooctanoic acid (PFOA): Mechanisms, volatile organofluorine emissions, and implications to thermal regeneration of granular activated carbon.

J Hazard Mater

November 2024

Department of Environmental Sciences, University of California, Riverside, CA 92521, United States; Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521, United States. Electronic address:

Article Synopsis
  • Thermal treatment effectively removes perfluorooctanoic acid (PFOA), but the impacts of temperature, heating methods, and granular activated carbon (GAC) on its breakdown and emission risks are still not completely understood.
  • Research showed that PFOA decomposes differently on quartz and GAC, producing various byproducts, including perfluoro-1-heptene and long-chain volatile organic fluorine (VOF) compounds, depending on the temperature during pyrolysis.
  • Key processes like decarboxylation and further decomposition of PFOA occur at different temperature ranges, with decarboxylation starting at 120°C and more complex transformations needing over 200°C, which can help improve methods for
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Objective: Educational offerings to fill the bioinformatics knowledge gap are a key component to enhancing access and use of health data from the All of Us Research Program. We developed a Train the Trainer-based, innovative training series including project-based learning, modular on-demand demonstrations, and unstructured tutorial time as a model for educational engagement in the All of Us community.

Materials And Methods: We highlight our training modules and content, with training survey data informing cycles of development in the creation of a 6-module training series with modular demonstrations.

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Per- and polyfluoroalkyl substances (PFAS) are persistent chemicals of increasing concern to human health. PFAS contamination in water systems has been linked to a variety of sources including hydrocarbon fire suppression activities, industrial and military land uses, agricultural applications of biosolids, and consumer products. To assess PFAS in California tap water, we collected 60 water samples from inside homes in four different geographic regions, both urban and rural.

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Children born small for gestational age (SGA) may be at risk for earlier puberty and adverse long-term health sequelae. This study investigates associations between SGA and age at menarche using secondary data on 1,027 female children in a population-based U.S.

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Article Synopsis
  • - The discovery of biomarkers for drug development is constrained by limited tissue samples from core needle biopsies, which can hinder the analysis of tissue heterogeneity and cell interactions due to standard 'omics platforms consuming large amounts of tissue.
  • - Current spatial transcriptomics technologies have low throughput and limited transcriptome coverage, while the Digital Spatial Profiling (DSP) method allows for scalable analysis of the entire transcriptome and high-plex protein analysis from a single tissue slide.
  • - The DSP Scientific Consortium has established best practices to enhance the use of spatial biology tools in drug discovery, aiming to optimize tissue analysis across various research fields to better understand disease biology and discover potential therapeutic targets.
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Potential implications of natural compounds on aging and metabolic regulation.

Ageing Res Rev

November 2024

Key Laboratory of Geriatric Nutrition and Health of Ministry of Education, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China. Electronic address:

Article Synopsis
  • * Natural compounds have shown significant promise in slowing down aging by influencing metabolic processes and pathways.
  • * Future research should aim to discover new natural compounds and utilize metabolomics to better understand how to effectively regulate metabolism to extend lifespan.
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Formaldehyde has been found to decrease virus concentrations in feed and ingredient matrices. Continued research is needed to identify the appropriate inclusion levels and application time for different viruses in these matrices. The objective was to evaluate different inclusion levels of formaldehyde when applied either pre- or postinoculation of porcine epidemic diarrhea virus (), type 2 porcine reproductive and respiratory syndrome virus (), and Seneca Valley virus 1 () to complete feed or soybean meal.

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Background: Bone defects, especially critical-size bone defects, and their repair pose a treatment challenge. Osteoinductive scaffolds have gained importance given their potential in bone tissue engineering applications.

Methods: Polycaprolactone (PCL) scaffolds are used for their morphological, physical, cell-compatible and osteoinductive properties.

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Treatment effect waning (TEW) refers to the attenuation of treatment effects over time. Assumptions of a sustained immuno-oncologic treatment effect have been a source of contention in health technology assessment (HTA). We review how TEW has been addressed in HTA and in the wider scientific literature.

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