An analysis of ranibizumab treatment and visual outcomes in real-world settings: the UNCOVER study.

Purpose: To describe intravitreal ranibizumab treatment frequency, clinical monitoring, and visual outcomes (including mean central retinal thickness [CRT] and visual acuity [VA] changes from baseline) in neovascular age-related macular degeneration (nAMD) in real-world settings across three ranibizumab reimbursement scenarios in the Middle East, North Africa, and the Asia-Pacific region.

Methods: Non-interventional multicenter historical cohort study of intravitreal ranibizumab use for nAMD in routine clinical practice between April 2010 and April 2013. Eligible patients were diagnosed with nAMD, received at least one intravitreal ranibizumab injection during the study period, and had been observed for a minimum of 1 year (up to 3 years).

Uteroglobin and FLRG concentrations in aqueous humor are associated with age in primary open angle glaucoma patients.

Background: The pathophysiological changes occurring in the trabecular meshwork in primary open angle glaucoma are poorly understood, but are thought to include increased extracellular matrix deposition, trabecular meshwork cell apoptosis, inflammation, trabecular meshwork calcification and altered protein composition of the aqueous humor. Although many proteins are present in aqueous humor, relatively few have been studied extensively, and their potential roles in primary open angle glaucoma are unknown.

Methods: Analyte concentrations in aqueous humor from 19 primary open angle glaucoma and 18 cataract patients were measured using a multiplex immunoassay.

Genome-Wide Association Shows that Pigmentation Genes Play a Role in Skin Aging.

Loss of fine skin patterning is a sign of both aging and photoaging. Studies investigating the genetic contribution to skin patterning offer an opportunity to better understand a trait that influences both physical appearance and risk of keratinocyte skin cancer. We undertook a meta-analysis of genome-wide association studies of a measure of skin pattern (microtopography score) damage in 1,671 twin pairs and 1,745 singletons (N = 5,087) drawn from three independent cohorts.

Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration.

Primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) are leading causes of irreversible blindness. Several loci have been mapped using genome-wide association studies. Until very recently, there was no recognized overlap in the genetic contribution to AMD and POAG.

Cystoid macular edema after femtosecond laser-assisted versus phacoemulsification cataract surgery.

Purpose: To evaluate the incidence of postoperative clinical cystoid macular edema (CME) associated with femtosecond laser-assisted cataract surgery (Catalys laser system) versus phacoemulsification cataract surgery.

Setting: Launceston Eye Institute, Launceston, Tasmania, Australia.

Design: Nonrandomized, single-surgeon, prospective, comparative cohort case series.

Leucapheresis for management of retinopathy in chronic myeloid leukaemia.

Chronic myeloid leukaemia is a myeloproliferative neoplasm characterised by granulocytic hyperplasia in the bone marrow and the presence of a specific cytogenetic abnormality known as Philadelphia chromosome with fusion of breakpoint cluster region (BCR) and ableson (ABL) genes. Retinopathy is a rare sight-threatening complication of chronic myeloid leukaemia, which occurs due to leucostasis in retinal blood vessels. We report a case of a patient who presented with visual impairment due to leucostasis, who was successfully managed by leucapheresis along with BCR-ABL tyrosine kinase inhibitor.

TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients.

Purpose: Elevated intraocular pressure (IOP) is the only known modifiable risk factor for primary open angle glaucoma (POAG), and it can be caused by reduced aqueous humor outflow from the anterior chamber. Outflow is predominantly regulated by the trabecular meshwork, consisting of specialized cells within a complex extracellular matrix (ECM). An imbalance between ECM-degrading matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs) within the trabecular meshwork is thought to contribute to POAG.

Fifty-year follow-up and Strampelli anterior chamber intraocular lens.

The Strampelli anterior chamber intraocular lens was created in 1953, and was primarily used to treat myopia and aphakia. Due to the positioning of the lens, it was associated with a number of complications, and was later modified to decrease the rate of significant complications, including endothelial cell loss. This paper describes a 62-year-old man, who has had a Strampelli intraocular lens (IOL) in situ for 52 years, with relatively few complications.

Femtosecond laser-assisted cataract surgery versus standard phacoemulsification cataract surgery: outcomes and safety in more than 4000 cases at a single center.

Purpose: To compare the intraoperative complications and safety of femtosecond laser-assisted cataract surgery and conventional phacoemulsification cataract surgery.

Setting: Single center.

Design: Prospective consecutive comparative cohort case series.

Bilateral maculopathy associated with sertraline.

Objective: We report a rare case of bilateral maculopathy that developed with the initiation of sertraline.

Methods: We conducted a case report and review of the literature.

Results: A 23-year-old man rapidly developed maculopathy with associated visual blurring after the initiation of sertraline.

Effect of femtosecond laser-assisted cataract surgery on the corneal endothelium.

Purpose: To compare the effect on the corneal endothelium of femtosecond laser-assisted cataract surgery and conventional phacoemulsification cataract surgery.

Setting: Private clinic, Tasmania, Australia.

Design: Prospective comparative cohort study.

Hypomethylation of the IL17RC promoter in peripheral blood leukocytes is not a hallmark of age-related macular degeneration.

Age-related macular degeneration (AMD) is a leading cause of visual impairment worldwide. Aberrant DNA methylation within the promoter of IL17RC in peripheral blood mononuclear cells has recently been reported in AMD. To validate this association, we examined DNA methylation of the IL17RC promoter in peripheral blood.

Cost-effectiveness of femtosecond laser-assisted cataract surgery versus phacoemulsification cataract surgery.

Purpose: To perform a comparative cost-effectiveness analysis (CEA) of femtosecond laser-assisted cataract surgery (LCS) and conventional phacoemulsification cataract surgery (PCS) DESIGN: Retrospective CEA using computer-based econometric modeling.

Participants: Hypothetical cohort of patients undergoing cataract surgery in the better eye based on a review of the current literature and our direct experience using LCS.

Methods: A cost-effectiveness decision tree model was constructed to analyze the cost-effectiveness of LCS compared with PCS.

Anterior chamber flare after femtosecond laser-assisted cataract surgery.

Purpose: To determine whether postoperative ocular inflammation is less after femtosecond laser-assisted cataract surgery than after conventional phacoemulsification (manual) cataract surgery.

Setting: Private clinic, Launceston, Tasmania, Australia.

Design: Prospective consecutive investigator-masked nonrandomized parallel cohort study.

Bilateral nanophthalmic uveal effusion syndrome: clinical presentation and surgical management.

Purpose: To describe the clinical presentation and surgical management of bilateral uveal effusion syndrome in a type 1 diabetic patient with nanophthalmos.

Methods: A 38-year-old man presented with decreased visual acuity. Fundus examination revealed exudative retinal detachment and choroidal folding.

Intraocular pressure during femtosecond laser pretreatment of cataract.

Purpose: To analyze the course of intraocular pressure (IOP) during femtosecond laser pretreatment to cataract surgery.

Setting: Launceston Eye Institute, Tasmania, Australia.

Design: Interventional prospective study.