1 results match your criteria: "Lanzhou University Lanzhou 730000 China zhangbx@lzu.edu.cn.[Affiliation]"
Unveiling the anticancer potential of plumbagin: targeting pyruvate kinase M2 to induce oxidative stress and apoptosis in hepatoma cells.
RSC Med Chem
September 2024
State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University Lanzhou 730000 China
Article Synopsis
- Pyruvate kinase M2 (PKM2) is an important enzyme that is often overexpressed in cancer cells, making it a target for cancer treatments aimed at blocking glycolysis.
- The study identifies plumbagin, a compound from a plant, as a novel inhibitor of PKM2, which decreases its activity and leads to reduced expression of related downstream genes in HepG2 cancer cells.
- Plumbagin also induces oxidative stress and mitochondrial damage, resulting in increased apoptosis, while simultaneously decreasing cell migration and proliferation, highlighting its potential as an anticancer therapeutic.