Ovarian adenomyoma: a case report.

Introduction: Ovarian adenomyoma is a rare gynecological tumor with a high misdiagnosis rate, leading many patients to undergo unnecessary surgeries that may affect fertility. Menstrual abdominal pain is the most common symptom, and auxiliary examinations often cannot clarify its nature. It often relies on intraoperative diagnosis, and surgical resection can achieve good therapeutic effects.

Development and validation of a diagnostic nomogram model for osteoporosis in the elderly using 3D multi-echo Dixon sequence combined with magnetization transfer imaging.

Objective: To develop a novel combined nomogram based on 3D multi-echo Dixon (qDixon), magnetization transfer imaging (MTI) and clinical risk factors for the diagnosis of osteoporosis.

Materials And Methods: A total of 287 subjects who underwent MR examination with qDixon and MTI sequences participated in this study. These participants were randomly assigned to a training cohort and a validation cohort at a ratio of 7:3.

Removal of mixed PhACs by combined UV/HO and biologically activated carbon process: Toxicity assessment, transformation products and microbial community.

This study examined the removal and toxicity reduction of mixed pharmaceutically active compounds (PhACs), including carbamazepine, erythromycin, gemfibrozil, and diclofenac, in the UV/HO tandem with biologically activated carbon (UV/HO-BAC) process and explored potential detoxification mechanisms. Results indicated that the combined process effectively removed the mixed PhACs, with the UV/HO segment being the primary contributor. As distinct from concentration removal, the effluent toxicity significantly increased after UV/HO treatment.

Bradykinin attenuates NiSO-induced autophagy in MIN6 cells and protects islet function in mice by regulating the PI3K/AKT/mTOR signaling pathway.

Previous studies have shown that nickel sulfate (NiSO) increases autophagy in thyroid cells and tissues. As an important organ of the endocrine system, the pancreas not only contributes to the exocrine function of digestion but also has the endocrine function of regulating blood sugar. However, it remains unknown whether NiSO increases pancreatic autophagy.

Synthesis of bioisosteres of caffeic acid phenethyl ester: 1,3,4-oxadiazole derivatives containing a catechol fragment with anti-inflammatory activities in vitro and in vivo.

Aimed to enhance the anti-inflammatory activity of caffeic acid phenethyl ester (CAPE), the oxadiazole derivatives were synthesized by substituting its ester group. The structure-activity relationships revealed that the electron-withdrawing group in the phenethyl moiety enhanced anti-inflammatory activity. The order of activity potency was F ≥ CF > Cl > NO > CN.

Maackiain induces apoptosis and autophagy via ROS-mediated endoplasmic reticulum stress in endometrial cancer.

Endometrial cancer (EC) is a common gynecological cancer, characterized by increasing incidence and mortality rates. Maackiain (MA), a natural flavonoid compound, has multiple biological activities, but little is known about how it affects EC cells. In the present study, CCK-8, EdU, colony formation, and flow cytometry assays were used to evaluate the effects of MA on EC cell proliferation, apoptosis, and reactive oxygen species (ROS) levels.

Isolation and identification of the causal agent of gummy stem blight disease in Cucumis sativus caused by a bacterial pathogen in China.

Recently, a new bacterial disease was detected on cucumber stalks. In order to study the pathogenesis of this disease, the pathogenic bacteria were isolated and identified on the basis of morphological and molecular characteristics, and further analyzed for pathogenicity and antagonistic evaluation. Pathogenicity analysis showed that HlJ-3 caused melting decay and cracking in cucumber stems, and the strain reisolated from re-infected cucumber stalks was morphologically identical to HlJ-3 colonies, which is consistent with the Koch's postulates.

Analysis of full length transcriptome and resistance characteristics of Atraphaxis bracteata under drought.

Drought is one of the main environmental factors affecting plant survival and growth. Atraphaxis bracteata is a common desert plant mainly utilized in afforestation and desertification control. This study analyzed the morphological, physiological and molecular regulatory characteristics of different organs of A.

Earthworm inspired lubricant self-pumping hydrogel with sustained lubricity at high loading.

The development of mechanically robust super-lubrication hydrogel materials with sustained lubricity at high contact pressures is challenging. In this work, inspired by the durable lubricity feature of the earthworm epidermis, a multilevel structural super-lubrication hydrogel (MS-SLH) system, the so-called lubricant self-pumping hydrogel, is developed. The MS-SLH system is manufactured by chemically dissociating a double network hydrogel to generate robust and wrinkled lubrication layer, and then laser etching was used to generate cylindrical texture pores as gland-like pockets for storing lubricants.

Identification and resolution of drug-related problems in the cardiovascular surgery unit of a tertiary hospital in China: a retrospective study.

Objective: The prevalence and characteristics of drug-related problems (DRPs) in the cardiovascular surgery unit have not been adequately explored, leaving a gap in our understanding of this critical issue. This study aimed to address this gap by determining the prevalence, characteristics of DRPs and identifying factors associated with their occurrence.

Methods: During a non-consecutive 48-month study period, a retrospective analysis was conducted to investigate DRPs and the interventions carried out by pharmacists for patients undergoing cardiovascular surgery.

Heparin rebound in patients undergoing off-pump coronary artery bypass grafting surgery: a single-center retrospective study.

Background: Heparin, an anticoagulant used in cardiac surgery, can result in heparin rebound (HR), where it returns postoperatively despite being neutralized with protamine. This study was designed to investigate the prevalence of HR in patients undergoing off-pump coronary artery bypass grafting (OPCAB) and evaluate the impact of HR on their short-term outcomes.

Methods: HR was defined by a 10% increase in activated coagulation time (ACT) following two hours of heparin neutralization with protamine, bleeding over 200 mL/h, and abnormal laboratory coagulation examination results.

Design and implication of a breast cancer-targeted drug delivery system utilizing the Kisspeptin/GPR54 system.

Kisspeptins function as endogenous ligands for the G protein-coupled receptor GPR54. While the primary role of the Kisspeptin/GPR54 signaling pathway pertains to reproduction, several studies have shown that GPR54 is highly expressed in breast cancer, and we further confirmed this result that GPR54 expression is significantly upregulated in breast cancer cells. Based on this finding, we developed a liposomal drug delivery system utilizing the Kisspeptin/GPR54 system to treat breast cancer after confirming the safety of Kp-10-228.

The specific extraction of glabridin from licorice residues using molecular imprinting technique.

The large-scale production of glycyrrhizic acid inevitably generates a large amount of licorice residues waste, which contains a wealth of active ingredients, especially glabridin, a natural preservative. However, traditional extraction methods for glabridin are often limited by bottlenecks such as time-consuming, inefficient, and insufficient specificity. To overcome these challenges, this study innovatively introduced 2-phenylimidazole as a functional monomer by computer simulations and successfully developed magnetic molecularly imprinted polymers (MMIPs) for glabridin.

Ancient engineers: The role of plateau pika in shaping ecological uniqueness and guiding plant diversity conservation in alpine grasslands.

Small burrowing herbivores play a crucial role in maintaining structure and function of grassland ecosystems. To date, our understanding of whether practicing ecological uniqueness can enhance plant diversity conservation under small herbivore disturbances remains limited. Here, we investigate the ecological uniqueness of plant communities, which include habitats disturbed and undisturbed by plateau pikas.

High-Strength Anisotropic Fluorescent Hydrogel Based on Solvent Exchange for Patterning.

Aggregation-induced emission (AIE)-active fluorescent hydrogel materials have found extensive applications in soft robotics, wearable electronics, information encryption, and biomedicine. Nevertheless, it continues to be difficult to create hydrogels that are both highly luminescent and possess strong mechanical capabilities. This study introduces a combined approach of prestretching and solvent exchange to create anisotropic luminous hydrogels made of poly(methacrylic acid-methacrylamide).

Investigating the Current-Carrying Friction Mechanism of n-Type and p-Type Two-Dimensional TMD under a Positive Electric Field.

Nanofriction plays an important role in the performance and lifetime of n-type or p-type TMD-based semiconductor nanodevices. However, the mechanism of nanofriction in n-type and p-type TMD semiconductors under an electric field is still blurry. In this paper, monolayers of n-MoSe and p-WSe materials were prepared by chemical vapor deposition (CVD), and their nanofriction behavior under positive electric field was investigated.

Electroacupuncture improves postoperative cognitive dysfunction by inhibiting ferroptosis via the TFR1-DMT1-FPN pathway.

Objective: The aim of this study was to investigate the role of ferroptosis in the occurrence of postoperative cognitive dysfunction (POCD) using a mouse model and to elucidate whether electroacupuncture (EA) can improve POCD by suppressing ferroptosis via the transferrin receptor 1 (TFR1)-divalent metal transporter 1 (DMT1)-ferroportin (FPN) pathway.

Methods: The experiment involved three groups: the control group, the POCD group and the POCD + EA group. The POCD animal model was established using sevoflurane anesthesia and tibial fracture.

Source Causal Connectivity Noninvasively Predicting Surgical Outcomes of Drug-Refractory Epilepsy.

Aims: Drug-refractory epilepsy (DRE) refers to the failure of controlling seizures with adequate trials of two tolerated and appropriately chosen anti-seizure medications (ASMs). For patients with DRE, surgical intervention becomes the most effective and viable treatment, but its success rate is unsatisfactory at only approximately 50%. Predicting surgical outcomes in advance can provide additional guidance to clinicians.

A Crystalline 3D Supramolecular Polymer Constructed by Clamparene-Based Controllable Self-Assembly and Its Application in Photothermal Conversion.

The development of well-defined three-dimensional supramolecular polymers presents significant challenges, particularly in achieving crystalline state structures. This study addresses this challenge by presenting the construction of a crystalline three-dimensional supramolecular polymer through the self-assembly of clamparene () and a naphthalene diimide derivative () in the solid state. The hierarchical self-assembly progresses from one-dimensional linear supramolecular polymers to two-dimensional supramolecular polymers and ultimately to a crystalline three-dimensional supramolecular polymer.

Long afterglow hybrid nanoplatform for integrated NIR-Ⅱ imaging diagnosis and triple-synergistic treatment of choroidal melanoma.

The key to the treatment of choroidal melanoma (CM) is to improve diagnostic efficiency and find a high-performance treatment to replace the traditional treatment of radiotherapy and enucleation. In this paper, for the first time, long afterglow luminescence material was applied to the integrated diagnosis and treatment of eyes, with its unique advantages in photoluminescence and afterglow luminescence to solve the bottleneck problem of real-time irradiation required for photothermal and photodynamic therapy (PTT and PDT). Based on the excellent photoluminescence and afterglow properties of ZnGaGeO:CrYbEr (ZGGO) nanoparticles, a nanoplatform ZGGO@Au@UiO-66@ZnPc:Dox-FA (GAUZD-FA) for NIR-Ⅱ imaging and triple-synergistic therapy (PTT, PDT and sustained-release drug) was constructed.

The association between perceived student gratitude and teacher family role performance: A moderated mediation model.

Objective: In recent years, numerous studies have highlighted the positive impact of student gratitude on individual development. However, a significant gap remains in the literature concerning how student gratitude influences teachers' family behavioral performance in their daily lives. This paper introduces Conservation of Resources (COR) Theory to examine the mediating effect of work-family enrichment on the relationship between student gratitude and teachers' family role performance, while also investigating whether intrinsic motivation moderates this relationship.

A nested case-control study on the effect of sarcopenia on mild cognitive impairment using the CHARLS database.

Objective: This study aimed to assess the influence of sarcopenia on mild cognitive impairment (MCI) through a nationally representative survey.

Method: Participants in this nested case-control study were from the China Health and Retirement Longitudinal Study (CHARLS) cohort. In 2015, 3222 participants were included, with 2304 participants were followed up in 2018.

Arbuscular mycorrhizal fungi mitigate cadmium stress in maize.

Soil cadmium (Cd) pollution poses a significant environmental threat, impacting global food security and human health. Recent studies have highlighted the potential of arbuscular mycorrhizal (AM) fungi to protect crops from various heavy metal stresses, including Cd toxicity. To elucidate the tolerance mechanisms of maize in response to Cd toxicity under AM symbiosis, this study used two maize genotypes with contrasting Cd tolerance: Zhengdan958 (Cd-tolerant) and Zhongke11 (Cd-sensitive).