799 results match your criteria: "Lancashire Teaching Hospitals NHS Foundation[Affiliation]"
BMJ
July 2024
Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Royal Preston Hospital, Preston, UK
Clin Med (Lond)
July 2024
Department of Neurology, Lancashire Teaching Hospitals NHS Foundation Trust, PR2 9HT, United Kingdom; University of Central Lancashire, Preston, PR1 2HE, United Kingdom.
Motor neuron disease (MND) is an uncommon but invariably fatal condition, with a median survival of 24-48 months from symptom onset. Although there is no cure at the moment, early diagnosis is crucial to enable timely access to multidisciplinary care, and enrolment in clinical trials utilising investigational therapies. Unfortunately, diagnostic delays remain common, and the average delay between symptom onset and diagnosis is 12 months.
View Article and Find Full Text PDFFront Neurosci
June 2024
Department of Psychology, Lancaster University, Lancaster, United Kingdom.
Introduction: Cognitive dysfunction is commonplace in Motor Neurone Disease (MND). However, due to the prominent motor symptoms in MND, assessing patients' cognitive function through traditional cognitive assessments, which oftentimes require motoric responses, may become increasingly challenging as the disease progresses. Oculomotor pathways are apparently resistant to pathological degeneration in MND.
View Article and Find Full Text PDFEur Urol
December 2024
Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Int J Retina Vitreous
July 2024
Lancashire Eye Centre, Lancashire Teaching Hospitals NHS Foundation Trust, Preston Rd, Chorley, PR7 1PP, UK.
Background: Dislocated IOL exchange conventionally involves manipulation within the anterior chamber which risks secondary injury to anterior chamber structures. We describe and evaluate a 4-haptic IOL rescue technique that avoids entering the anterior chamber and thus minimizes post operative inflammation, astigmatism and recovery time relative to conventional IOL explantation and replacement techniques.
Methods: Retrospective, non-randomized, interventional study of all patients undergoing 4-haptic IOL rescue performed by two independent vitreoretinal surgeons at a single UK centre over two years.
Cureus
June 2024
Intensive Care, Blackpool Victoria Hospital, Blackpool, GBR.
A woman in her 60s initially presented with rapid-onset left-sided hemiparesis with later development of slurred speech and left-sided facial droop. Despite ruling out common causes, her condition rapidly progressed with the development of bilateral proximal weakness, ophthalmoplegia, ataxia, and pyramidal signs eventually leading to a cardiorespiratory arrest. Extensive investigations, including computerised tomography (CT), magnetic resonance imaging (MRI), and lumbar puncture (LP), were negative for infectious or vascular aetiologies.
View Article and Find Full Text PDFEpilepsy Behav
September 2024
Cornwall Intellectual Disability Equitable Research (CIDER), Cornwall Partnership NHS Foundation Trust, United Kingdom; CIDER, Peninsula School of Medicine, University of Plymouth, United Kingdom. Electronic address:
Introduction: In England, nearly a quarter of people with intellectual disability (PwID) have epilepsy. Though 70 % of PwID have pharmaco-resistant seizures only 10 % are prescribed anti-seizure medication (ASMs) licenced for pharmaco-resistance. Brivaracetam (BRV) licenced in 2016 has had nine post-marketing studies involving PwID.
View Article and Find Full Text PDFNeurol Int
May 2024
Global Health Neurology Lab, Sydney, NSW 2150, Australia.
: This study aims to develop and validate the Futile Recanalization Prediction Score (FRPS), a novel tool designed to predict the severity risk of FR and aid in pre- and post-EVT risk assessments. : The FRPS was developed using a rigorous process involving the selection of predictor variables based on clinical relevance and potential impact. Initial equations were derived from previous meta-analyses and refined using various statistical techniques.
View Article and Find Full Text PDFBackground: Palliative care provision should be driven by high quality research evidence. However, there are barriers to conducting research. Most research attention focuses on potential patient barriers; staff and organisational issues that affect research involvement are underexplored.
View Article and Find Full Text PDFJ Clin Oncol
August 2024
Alison Birtle, MBBS, MRCP, FRCR, MD, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK, University of Manchester, Manchester, UK, University of Central Lancashire, Preston, UK; Robert Jones, MBChB, PhD, University of Glasgow, Glasgow, UK, Beatson West of Scotland Cancer Centre, Glasgow, UK; and Fay H. Cafferty, PhD , Katie Biscombe, MSc, and Emma Hall, PhD, The Institute of Cancer Research, London, UK.
Br J Neurosci Nurs
August 2023
NIHR Applied Research Collaboration North West Coast (ARC NWC), Methodological Innovation, Development, Adaptation and Support (MIDAS) Theme.
Advanced Parkinson's disease affects patients with existing Parkinson's disease by further deteriorating their physical and cognitive functions. In this commentary we critically assess an economic evaluation which compared the cost-effectiveness of levodopa/carbidopa intestinal gel against standard of care in treating patients with Advanced Parkinson's disease. While the economic evaluation indicated that levodopa/carbidopa intestinal gel could be cost-effective within the UK parameters, we highlight important limitations related to its design, modelling and analysis.
View Article and Find Full Text PDFBr J Card Nurs
August 2023
University of Central Lancashire, Preston, UK.
There is a long history of BAME under-representation in medical research. Underrepresentation of minority ethnic groups have been assessed by several studies, showing that black and minority ethnic groups were less likely to participate and engage in medical research when compared to white British groups (in relation to education, occupation, health, belief, and attitudes to medical research).There may be several strategies that improve inclusivity, including translation of participant information, culturally specific recruitment, and adaptations to the invitation process.
View Article and Find Full Text PDFPulm Ther
June 2024
Department of Respiratory Paediatrics, Alder Hey Children's Hospital, Liverpool, UK.
Worldwide, over 2 billion children under the age of 5 experience stunting, wasting, or are underweight. Malnutrition contributes to 45% of all deaths in this age group (approximately 3.1 million deaths) [1].
View Article and Find Full Text PDFLancet
June 2024
Division of Psychiatry, University College London, London, UK.
Background: Motor neuron disease is a progressive, fatal neurodegenerative disease for which there is no cure. Acceptance and Commitment Therapy (ACT) is a psychological therapy incorporating acceptance, mindfulness, and behaviour change techniques. We aimed to evaluate the effectiveness of ACT plus usual care, compared with usual care alone, for improving quality of life in people with motor neuron disease.
View Article and Find Full Text PDFSurgeon
August 2024
Department of Trauma and Orthopaedic Surgery, Lancashire Teaching Hospitals NHS Foundation Trust, UK.
Background: Total hip replacement (THR)is typically cemented, cementless or hybrid depending on patient factors and surgeon preference. To date no studies have evaluated waste generated with each of these procedures in relation to implant choice, and particularly waste related to consumables. We aimed to quantify the volume; type and ability to recycle this waste and suggest potential strategies for reducing the overall waste related to consumables in THR.
View Article and Find Full Text PDFJ Med Microbiol
May 2024
University of Central Lancashire, Fylde Rd, Preston PR1 2HE, UK.
The term 'diagnostic stewardship' is relatively new, with a recent surge in its use within the literature. Despite its increasing popularity, a precise definition remains elusive. Various attempts have been made to define it, with some viewing it as an integral part of antimicrobial stewardship.
View Article and Find Full Text PDFClin Kidney J
May 2024
Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, Lancashire, UK.
Br J Oral Maxillofac Surg
June 2024
Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.
Temporomandibular disorders include a wide spectrum of extra-articular and intra-articular conditions affecting the temporomandibular joint (TMJ). In salvage cases involving intra-articular end-stage disease, alloplastic temporomandibular joint replacement (TMJR) is a management option which can be utilised to rehabilitate a disabled joint's function and form. Whilst post-TMJR infection is rare, it is one of the most serious complications.
View Article and Find Full Text PDFFuture Healthc J
March 2024
Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, U.K.
Eur J Surg Oncol
June 2024
Department of Upper Gastrointestinal Surgery, Queen Elizabeth Hospital Birmingham, Birmingham, UK. Electronic address:
Background: Both anastomotic leak (AL) and conduit necrosis (CN) after oesophagectomy are associated with high morbidity and mortality. Therefore, the identification of preoperative, modifiable risk factors is desirable. The aim of this study was to generate a risk scoring model for AL and CN after oesophagectomy.
View Article and Find Full Text PDFBrain Spine
March 2024
Department of Neurosurgery, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.
Introduction: Leptomeningeal melanocytomas are rare tumours originating from neural crest derived melanocytes. They are usually solitary and presentation with multifocal meningeal melanocytoma is very rare and indicative of potentially more aggressive behaviour. This case report and scoping review sought to evaluate the presentation, and key radiological features that can help differentiate multifocal meningeal melanocytoma from other differentials and provide a discussion of the key management and prognostic points once these tumours are diagnosed.
View Article and Find Full Text PDFDiabetologia
July 2024
Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Aims/hypothesis: The risk of dying within 2 years of presentation with diabetic foot ulceration is over six times the risk of amputation, with CVD the major contributor. Using an observational evaluation of a real-world implementation pilot, we aimed to assess whether for those presenting with diabetic foot ulceration in England, introducing a 12-lead ECG into routine care followed by appropriate clinical action was associated with reduced mortality.
Methods: Between July 2014 and December 2017, ten multidisciplinary diabetic foot services in England participated in a pilot project introducing 12-lead ECGs for new attendees with foot ulceration.
Am J Clin Nutr
June 2024
Nutritional Epidemiology Observatory, Josué de Castro Nutrition Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
PLoS One
March 2024
Manchester Centre for Health Psychology, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.