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Proc Natl Acad Sci U S A
April 1997
Department of Medicine, Lakeside Veteran's Administration Hospital and Northwestern University Medical School, Chicago, IL 60611, USA.
The intestinal lamina propria (LP) is a major effector site of the mucosal immune system where antigen-specific and antigen-nonspecific factors shape the functional responses of CD4+ T helper cells. To study the functional differentiation of LP T helper cells we utilized DO11.10 T cell receptor (TCR) transgenic (Tg) mice that expressed a clonotypic TCR specific for a class II major histocompatibility complex-restricted peptide of chicken ovalbumin.
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