Design, Synthesis, and Preclinical Evaluation of a High-Affinity F-Labeled Radioligand for Myocardial Growth Hormone Secretagogue Receptor Before and After Myocardial Infarction.

The peptide hormone ghrelin is produced in cardiomyocytes and acts through the myocardial growth hormone secretagogue receptor (GHSR) to promote cardiomyocyte survival. Administration of ghrelin may have therapeutic effects on post-myocardial infarction (MI) outcomes. Therefore, there is a need to develop molecular imaging probes that can track the dynamics of GHSR in health and disease to better predict the effectiveness of ghrelin-based therapeutics.

Spatial-social familiarity complements the spatial-social interface: evidence from Yellowstone bison.

Social animals make behavioural decisions based on local habitat and conspecifics, as well as memorized past experience (i.e. 'familiarity') with habitat and conspecifics.

Promoting mental health and wellbeing among post-secondary students with the JoyPop™ app: study protocol for a randomized controlled trial.

Background: Technology use may be one strategy to promote mental health and wellbeing among young adults in post-secondary education settings experiencing increasing distress and mental health difficulties. The JoyPop™ app is mobile mental health tool with a growing evidence base. The objectives of this research are to (1) evaluate the effectiveness of the JoyPop™ app in improving emotion regulation skills (primary outcome), as well as mental health, wellbeing, and resilience (secondary outcomes); (2) evaluate sustained app use once users are no longer reminded and determine whether sustained use is associated with maintained improvements in primary and secondary outcomes; (3) determine whether those in the intervention condition have lower mental health service usage and associated costs compared to those in the control condition; and (4) assess users' perspectives on the quality of the JoyPop™ app.

A Modified EMD Technique for Broken Rotor Bar Fault Detection in Induction Machines.

Induction machines (IMs) are commonly used in various industrial sectors. It is essential to recognize IM defects at their earliest stage so as to prevent machine performance degradation and improve production quality and safety. This work will focus on IM broken rotor bar (BRB) fault detection, as BRB fault could generate extra heating, vibration, acoustic noise, or even sparks in IMs.

An Experimental Test of Jealousy's Evolved Function: Imagined Partner Infidelity Induces Jealousy, Which Predicts Positive Attitude Towards Mate Retention.

Jealousy may have evolved to motivate adaptive compensatory behavior in response to threats to a valued relationship. This suggests that jealousy follows a temporal sequence: A perceived relational threat induces state feelings of jealousy which in turn motivates compensatory behavior, such as mate retention effort. Yet to date, tests of this mediation model have been limited to cross-sectional data.

Advancing Measurement-Informed Care in Outpatient Community Behavioral Health.

Measurement-informed care (MIC), also known as measurement-based care or patient-reported outcomes, for behavioral health conditions has had low uptake in the United States. To advance MIC in the near term, the authors reviewed nationally endorsed behavioral health measures and worked with national experts to recommend a core set of outpatient measures to prioritize for use. The resulting set of measures is for common behavioral and comorbid conditions and is outcomes based, low burden, and suitable for value-based payment.

GPT-4 as an X data annotator: Unraveling its performance on a stance classification task.

Data annotation in NLP is a costly and time-consuming task, traditionally handled by human experts who require extensive training to enhance the task-related background knowledge. Besides, labeling social media texts is particularly challenging due to their brevity, informality, creativity, and varying human perceptions regarding the sociocultural context of the world. With the emergence of GPT models and their proficiency in various NLP tasks, this study aims to establish a performance baseline for GPT-4 as a social media text annotator.

Thermal and Cardiovascular Responses during Exertional Heat Stress after Diphenhydramine Use: A Randomized Crossover Trial.

Introduction: Despite sparse systematic evidence, current exercise heat safety recommendations suggest that antihistamines blunt sweating and increase the risk for heat-related injury during exertional heat stress. The primary purpose of the present study was to examine whether diphenhydramine hydrochloride (DPH), a first-generation antihistamine, affects the sweating, core temperature, and heart rate (HR) response during exertional heat stress using a double-blind randomized crossover design.

Methods: On two occasions separated by >48 h, 20 healthy adults (10 females, 23 ± 3 yr, body surface area: 1.

Exploring Student Perspectives of the Dietetics Profession Using a Professional Socialization Lens.

We aimed to explore student perspectives of the dietetics profession using a professional socialization lens. We conducted qualitative semi-structured interviews, virtually or by phone, with 25 dietetic undergraduate/graduate students or interns in 2020/21. Transcripts were thematically analyzed.

An App for Navigating Patient Transportation and Acute Stroke Care in Northwestern Ontario Using Machine Learning: Retrospective Study.

Background: A coordinated care system helps provide timely access to treatment for suspected acute stroke. In Northwestern Ontario (NWO), Canada, communities are widespread with several hospitals offering various diagnostic equipment and services. Thus, resources are limited, and health care providers must often transfer patients with stroke to different hospital locations to ensure the most appropriate care access within recommended time frames.

Physics-informed scaling laws for the performance of pitching foils in schooling configurations.

This study introduces novel physics-based scaling laws to estimate the propulsive performance of synchronously pitching foils in various schooling configurations. These relations are derived from quasi-steady lift-based and added mass forces. Hydrodynamic interactions among the schooling foils are considered through vortex-induced velocities imposed on them, constituting the ground effect.

Increasing interprofessional collaboration in community-based palliative care: a pilot study of the CAPACITI education program for primary care providers.

Interprofessional collaboration in palliative care is essential to ensuring high-quality care for seriously ill patients. Education interventions to increase competency in palliative care should incorporate team-building skills to encourage an interprofessional approach. We developed and piloted a virtual educational program named CAPACITI for interprofessional teams to promote a community palliative approach to care.

Bimanual Coordination in Individuals Post-stroke: Constraints, Rehabilitation Approaches and Measures: Systematic Review.

To couple or not to couple is a dilemma for the CNS when performing bimanual goal-directed actions. Numerous interacting individual and task-related constraints contribute to the issue of effective movement coordination, and their impact on the emerging actions must be inferred from valid methodologies. This is particularly important when examining coordination in individuals with stroke undergoing rehabilitation.

Helping Others Facilitates Well-Being for Indigenous Peoples Living With HIV/AIDS in Canada.

Research has found that helping others facilitates well-being for Indigenous peoples living with HIV and AIDS, but limited research exists that investigates the mechanism(s) underlying this relationship. Indigenous perspectives posit that helping others facilitates well-being through the development of an individual's spiritual, physical, emotional, and mental aspects (four aspects). Similarly, self-determination theory posits that helping others facilitates well-being by satisfying basic psychological needs.

Omission of alcohol skin cleansing and risk of adverse events in long-term care residents undergoing COVID-19 vaccination: A cohort study.

Despite a lack of clinical data demonstrating the effectiveness of alcohol swab cleansing prior to vaccinations as a prophylactic measure to prevent skin infections, it is recommended for vaccine administration by the Canadian Immunization Guide. The objective of this study was to evaluate the risk of adverse events after omitting alcohol skin cleansing in long-term care (LTC) residents receiving vaccinations during the COVID-19 pandemic. Two medium-sized LTC homes participated in a cohort study, whereby one LTC used alcohol swab cleansing prior to resident vaccinations and the other did not.

An environmental scan of mental health services for indigenous youth in Canada.

Background: There is an urgent need for culturally and contextually relevant mental health support for First Nations, Inuit and Métis youth.

Objective: Our aim was to identify mental health and wellness services that are currently available to Indigenous youth across Canada.

Methodology: As a first step, we conducted a web-based environmental scan of services tailored to Indigenous youth.

Nature prescribing: emerging insights about reconciliation-based and culturally inclusive approaches from a tricultural community health centre.

This commentary highlights the importance of social and nature prescribing programs reflecting culturally diverse perspectives and practices. Creating and holding space for Indigenous and other worldviews should be a key priority of nature prescribing, a relatively recent practice in Canada that recognizes and promotes health benefits associated with engaging in a variety of activities in natural settings. Central to designing and delivering nature prescribing that is culturally inclusive and grounded in fulfilling obligations of reconciliation is recognizing the ongoing dominance of Western worldviews and their associated implications for decolonizing and Indigenizing nature-based programming.

Impact of a Remote Patient Monitoring Platform on Outcomes Following a Total Hip or Knee Arthroplasty.

Background: The coronavirus pandemic highlighted the need for remote patient monitoring to deliver and provide access to patient care and education. A mobile-based app providing interactive tools for patient education and monitoring was piloted at Thunder Bay Regional Health Sciences Centre (TBRHSC) in November 2020. We aimed to examine the platform's impact on postoperative length of stay, hospital readmissions, and emergency department (ED) visits 60 days postsurgery in total hip and knee arthroplasty patients in Northwestern Ontario.

The role, the risk, and the reciprocity: creating positive early rural placements in medical education.

Introduction: The Northern Ontario School of Medicine University seeks to address rural physician shortages in Northern Ontario. One key strategy the school employs is the use of experiential learning placements embedded throughout its undergraduate curriculum. In second year, students embark on two 4-week placements in rural and remote communities.