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MicroRNA-455-5p exerts inhibitory effect in cervical carcinoma through targeting S1PR1 and blocking mTOR pathway.
Arch Gynecol Obstet
May 2020
Department of Gynaecology and Obstetrics, Laiwu Central Hospital of Shandong Energy Xinwen Mining Group, Laiwu, 271100, Shandong, People's Republic of China.
Article Synopsis
- MicroRNA-455-5p (miR-455-5p) has been found to be downregulated in cervical carcinoma, which correlates with worse patient outcomes.
- The study utilized various laboratory methods to confirm that miR-455-5p suppresses cell growth and metastasis in cervical cancer, with S1PR1 identified as a direct target.
- Additionally, miR-455-5p promotes cell death and inhibits the mTOR signaling pathway, suggesting its potential as a therapeutic target in cervical cancer treatment.