1 results match your criteria: "Lahore University of Management Sciences Lahore 54792 Pakistan Muhammad.saeed@lums.edu.pk.[Affiliation]"
Facile synthesis of substituted 2-aroylbenzo[]thiophen-3-ols to form novel triazole hybrids using click chemistry.
RSC Adv
March 2024
Department of Chemistry and Chemical Engineering, Syed Babar Ali School of Science and Engineering, Lahore University of Management Sciences Lahore 54792 Pakistan
Article Synopsis
- - A new, efficient one-pot method for creating 2-aroylbenzo[]thiophen-3-ols is developed using 2-mercaptobenzoic acid and various aryl bromomethyl ketones with triethylamine as a catalyst.
- - The reaction likely involves a nucleophilic attack by the sulfhydryl group on the bromomethyl ketone, resulting in a cyclization that produces the target compound in high yield.
- - This process also allows for the introduction of an alkyne at the 3-hydroxy position, leading to the formation of unique benzothiophene-triazole hybrids, expanding possibilities for new biological and pharmaceutical discoveries.