1,613 results match your criteria: "Lagos University[Affiliation]"

Analysis of the Factors Affecting the Male-Female Sex Ratio of Babies Born through Assisted Reproductive Technology.

West Afr J Med

July 2024

Clinical Reader, Director Surgical Skills; Co-Lead MSc Human Clinical Embryology and Assisted Conception, Consultant Gynaecologist, School of Medicine; University of Dundee/Ninewells Hospital, United Kingdom.

Background: Until now, the sex ratio in a population is believed to be relatively stable with no male/female preponderance. There has been an increasing amount of evidence to suggest that assisted conception may significantly impact on sex ratio (SR). Several factors have been suggested to affect SR such as parental variables (paternal race, maternal age, and body mass index-(BMI), methods of fertilisation (in-vitro fertilisation/intracytoplasmic sperm injection), stage of embryo transfer (cleavage/blastocyst), type of IVF cycle (fresh/cryopreserved), medications used for controlled ovarian stimulation, poor sperm motility, and even culture media.

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Introduction: Hematologic inflammatory biomarkers derived from a full blood count (FBC) are elevated in Type 2 diabetes mellitus (DM). In low- and middle-income countries like Nigeria, a FBC is an affordable and easily available test, even in rural areas. Glycated hemoglobin (HbA1c), a measure of glycemic control, has been found to correlate with hematologic inflammatory markers.

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Purpose: Managing patients' health information is one of the building blocks of the health system and the adoption of health information technologies like electronic health records (EHRs) is expected to reduce the various challenges in keeping and accessing quality health-care data that aid decision-making among medical practitioners. This study aims to investigate how leadership styles and change management affected the job performance of health information management practitioners on their adoption of EHRs in tertiary hospitals in Nigeria.

Design/methodology/approach: The study used primary data collected using a Likert scale questionnaire from 117 health information management officers and health information technicians in selected tertiary hospitals in South-Eastern Nigeria.

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Effect of adequacy of empirical antibiotic therapy for hospital-acquired bloodstream infections on intensive care unit patient prognosis: a causal inference approach using data from the Eurobact2 study.

Clin Microbiol Infect

December 2024

OUTCOMEREA Research Group, Drancy, France; Institut National de la Santé et de la Recherche Medicale, Infection Antimicrobial Modelisation Evolution, U1137, Team Decision Science in Infectious Diseases, Paris, France; Assistance Publique Hôpitaux de Paris, Bichat hospital, Medical and infectious diseases ICU, F75018, Paris France. Electronic address:

Article Synopsis
  • Hospital-acquired bloodstream infections (HA-BSI) in ICU patients can be life-threatening, and this study aimed to see how early adequate antibiotic treatment affects 28-day mortality rates for patients who survive at least one day after infection onset.
  • Using data from a multicenter study with 2,418 patients, researchers found that those who received adequate treatment within 24 hours had a lower 28-day mortality rate (32.8%) compared to those who were inadequately treated (40%).
  • The study concluded that inadequate antibiotic therapy within 24 hours contributes significantly to 28-day mortality, indicating that quicker treatment could greatly improve patient outcomes in cases of HA-BSI.
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  • Researchers studied strokes from 1990 to 2021 to understand how many people get them and how they are affected around the world.
  • In 2021, strokes caused about 7.3 million deaths and were a major cause of health problems, especially in specific regions like Southeast Asia and Oceania.
  • There are differences in stroke risks based on where people live and their age, and some areas actually saw more strokes happening since 2015.
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Fragile X syndrome (FXS) is a significant cause of intellectual disability and autism, while Fragile X Premutation -Associated Conditions (FXPAC) are a significant cause of morbidity and mortality globally. This study assessed the level of knowledge and perceptions about FXS and FXPAC among doctors in Nigeria. It was a web-based, cross-sectional study conducted among a cohort of doctors in Nigeria.

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Giant "Hydra Headed" Uterine Fibroid in a Nullipara: A Case Report.

Clin Med Insights Case Rep

September 2024

Department of Obstetrics and Gynecology, Bayelsa Medical University, Yenagoa, Bayelsa State, Nigeria.

Background: Uterine fibroids, or Leiomyoma is a type of Smooth Muscle Tumors of the uterus (SMTs) and are common in the black race. Giant uterine fibroids, on the other hand, are uncommon and may occur during patient dissimulation. Dissimulation may occur because of a dread of surgery and hospitals visits, fear of surgical death, chronic intake of herbal concussion, and a religio-traditional strong belief system on instant healing following prayers, among others.

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Nasal Carriage, Antimicrobial Susceptibility Profile, and Enterotoxin Genes of Isolated from Children with Asthma.

Indian J Microbiol

September 2024

Department of Biological Sciences, College of Science and Technology, Covenant University, Canaan Land, KM 10 Idiroko Rd, Ota, 112104 Ogun State Nigeria.

Unlabelled: Asthma is a chronic respiratory disease that affects children worldwide. Increasing evidence suggests that contributes to the pathology of asthma. The aim of this study was to evaluate the nasal carriage, antimicrobial susceptibility profile, and presence of enterotoxin genes from isolated from children with asthma.

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To explore the association between COVID-19-related cancer treatment cancellations and the psychological health of cancer patients in Nigeria. We analyzed data collected from 15 outpatient cancer clinics, comprising 1,097 patients between April to July 2020. Study outcome was ten psychological impacts, including feeling down, stressed, and unable to access treatment due to COVID-19 (used as continuous and categorical variable (0-3,4-7,8+ events).

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Article Synopsis
  • Nigeria has the highest global rate of peripartum cardiomyopathy, leading to a clinical trial that compared usual care with AI-guided screening for left ventricular systolic dysfunction (LVSD) in pregnant and postpartum women.
  • The study involved 1,232 women, using digital stethoscopes and 12-lead electrocardiograms to identify LVSD, which was confirmed by echocardiography.
  • Results showed that AI screening enhanced the detection rates of LVSD (4.1% vs. 2.0% for stethoscope AI; 3.4% vs. 2.0% for electrocardiogram AI), with no serious adverse events reported during the trial.
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Introduction: The urinary bladder undergoes morphological and functional changes in patients with symptomatic benign prostatic enlargement (BPE). These detrusor changes reflect chronically increased intravesical pressure as a result of outlet obstruction. This study aims to determine the relationship between the Pre- and Post-op detrusor wall thickness (DWT), international prostate symptom score (IPSS), and duration of lower urinary tract symptoms (LUTS) in patients who had open simple prostatectomy (OSP).

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Background And Objectives: Prevalence of prediabetes and undiagnosed diabetes are different in rural and urban dwellings, with varying driving factors. This study aimed to determine the differences in risk factors of prediabetes and undiagnosed diabetes among Yoruba speaking adult dwellers in selected rural and urban communities in Nigeria using haemoglobin A1c.

Methods: A cross-sectional study was conducted in five selected states in Southwestern Nigeria.

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Background: Early childhood caries (ECC), a type of tooth decay that affects preschool children, is a complex chronic disease resulting from an imbalance of multiple risk factors and protective factors of tooth decay, over time. The antioxidant system in saliva is one of its defense mechanisms against disease agents. The pH of saliva also affects the integrity of the oral cavity, hence caries susceptibility.

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Background: Limited research capacity has contributed to the lack of high-quality research from low-and middle-income countries. This is compounded by limited research training opportunities. Research capacity scale-up training was deployed as part of the implementation of the National Surgical, Obstetrics, Anaesthesia, and Nursing Plan for Nigeria.

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Background: Palliative care evolution focuses on education and medication accessibility. As little as 12% of palliative care needs are met. Assessment of the domains of Palliative care and patients' and families' experience are essential in life-limiting conditions.

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Introduction: Postpartum anaemia is often caused by iron deficiency with onset during the antepartum period and can be exacerbated by excessive blood loss at birth. Its prevalence is estimated as 50-80% in low-income and middle-income countries. It poses adverse consequences on the mother and negatively impacts her ability to care for her newborn.

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Prcis: Patients' acceptance of glaucoma therapy was high overall in this study, but lower for surgery than for laser or medical therapy. Fear and cost were the leading reasons why patients declined recommended therapy and they were treatment-specific. Cost was the primary reason for declining medical and laser therapy, while fear was the most common reason for declining surgical therapy.

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Article Synopsis
  • There's a lack of information about inflammatory bowel disease (IBD) in Africa.
  • To tackle this, a network of doctors working on IBD was created in sub-Saharan Africa.
  • The report covers 175 cases from 12 different countries collected over a span of 2 years.
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  • - Prostate cancer mortality is high in Nigeria due to poor quality care and the need for early detection and effective management, prompting a study to identify barriers and facilitators affecting detection and treatment.
  • - Six focus group discussions with patients, caregivers, and healthcare providers highlighted barriers such as limited knowledge, misperceptions, and issues with centralized screening, while facilitators included the role of religious institutions in promoting health-seeking behavior.
  • - In terms of management, barriers included inconsistent clinical guidelines, financial constraints, and lack of patient support systems, whereas facilitators consisted of structured guidelines and support from peers and healthcare professionals to provide accurate information.
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Objective: To compare the weight, height, BMI and nutritional status of patients with and without cleft lip and/or cleft palate (CLP).

Design: Cross-sectional study.

Setting: Lagos University Teaching Hospital.

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1.7 billion children lack access to surgical care worldwide. The emergency, critical, and operative care (ECO) resolution represents a call to action to reinvigorate the efforts to address these disparities.

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Article Synopsis
  • Immunological therapies, including immune checkpoint inhibitors (ICIs) and cell-based therapies like CAR-T, have transformed cancer treatment by enabling the immune system to target cancer cells.
  • While these therapies are generally effective, they can cause immune-related adverse events (irAEs) that vary in severity and timing, from mild skin rashes to serious complications such as myocarditis or cytokine release syndrome.
  • The statement discusses the growing understanding of cardiovascular toxicities associated with these therapies, outlines their diagnosis and management, and identifies gaps in current research that need further exploration.
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