Concomitant sutureless scleral fixation of intraocular lens with keratoplasty: Review of surgical techniques.

Sutureless scleral fixation of intraocular lens (sSFIOL) is a commonly employed method of optical rehabilitation of aphakic patients with deficient capsular support, and corneal transplant surgeries can be simultaneously combined with sSFIOL to handle aphakic corneal opacities. A single-stage procedure circumvents the need for repeat intraocular procedures and carries lower risk of graft endothelial damage, endophthalmitis, and macular edema associated with sequential surgeries. However, it mandates surgical expertise and increases the chances of postoperative inflammation.

Effect of inhaled corticosteroids on serum periostin levels in adult patients with mild-moderate asthma.

Periostin is an extracellular matrix protein, and its expression is upregulated in airway epithelial cells in patients with bronchial asthma. Periostin may be a key molecule linked to type 2 T-helper cell inflammation. Inhaled corticosteroids (ICS) may suppress periostin-induced asthmatic inflammation.

A Randomized Controlled Trial to Compare the Efficacy of Intravenous Dexmedetomidine and Clonidine as Adjuvants to Low Dose Opioid in Attenuation of Hemodynamic Response to Laryngoscopy and Tracheal Intubation.

Increase in sympathetic activity as a result of cardiovascular stress response to laryngoscopy can be detrimental to the patient. The primary objective is to compare intravenous dexmedetomidine and clonidine as adjuvants to low dose opioid (fentanyl) for attenuation of hemodynamic response to laryngoscopy and tracheal intubation. The secondary objectives are to compare the perioperative dose requirement of fentanyl and thiopentone, to compare the duration of postoperative analgesia, and to look for side effects in all three groups.

Gender differences in depression and anxiety among atopic dermatitis patients.

Background: Dermatological patients invariably suffer one or the other psychological problems which may escalate to the extent of a mental disorder. One of the most common dermatological disorders is atopic dermatitis (AD), but the literature has limited data on gender differences for psychiatric morbidity in such patients.

Aims: To evaluate and compare gender differences in the prevalence of depression and anxiety in AD.

Attenuation of hemodynamic response to laryngoscopy and orotracheal intubation using intravenous clonidine.

Background And Aims: Alpha-2 agonists are being increasingly used as adjuncts in general anesthesia and the present study was carried out to study the effect of clonidine as an adjuvant to low dose fentanyl in attenuating the hemodynamic response to laryngoscopy and orotracheal intubation.

Materials And Methods: Ninety female patients belonging to American Society of Anesthesiologists (ASA) physical status I, II, and III in age group 25-65 years, body mass index (BMI) 21-26 kg/m(2), and diagnosed as carcinoma breast scheduled for breast surgery were included in this Prospective, randomized, placebo-controlled study. One-way analysis of variance (ANOVA), paired t-test, and chi-square test was applied where deemed appropriate.

Primary thyroid lymphoma: A rare disease.

Primary thyroid lymphomas are rare neoplasms comprising of 1-5% of thyroid malignancies. These are predominantly B-cell in origin. Here, we report a case of 60 years lady, a known case of lymphocytic thyroiditis, diagnosed as thyroid lymphoma (diffuse large B-cell) on fine needle aspiration and confirmed histopathogically and immunohistochemically.

Supervised conventional interferon α2a in combination with ribavirin therapy is the preferred alternative for treatment of chronic hepatitis C.

Objective: To document the significant sustained virological response with supervised conventional interferon α and ribavirin therapy in hepatitis C virus (HCV)-infected patients, this study was planned.

Materials And Methods: Sixty chronic hepatitis C naive patients were included in this study. Complete blood counts, prothrombin time, ALT, AST, and qualitative HCV RNA were done.

The effect of addition of intrathecal clonidine to hyperbaric bupivacaine on postoperative pain after lower segment caesarean section: A randomized control trial.

Background: Intrathecal clonidine prolongs spinal anesthesia but the optimum dose to be used in cesarean delivery is not yet known. We evaluated the effect of addition of intrathecal clonidine to hyperbaric bupivacaine on postoperative pain after lower segment caesarean section.

Methods: A total of 105 parturients carrying a singleton fetus at term, scheduled to undergo elective LSCS under spinal anesthesia were randomized in a double blind fashion to one of the three groups.

Synchronous carcinosarcoma uterus and primary serous carcinoma of bilateral fallopian tubes: a case report.

Background: The coexistence of multiple primary tumors in the female genital tract is very rare. Carcinosarcoma of the uterus is very rarely encountered among multiple genital malignancies.

Case: A 63-year-old woman presented with synchronous carcinosarcoma of the uterus and primary serous carcinoma of bilateral fallopian tubes.

A randomized controlled trial to compare fentanyl-propofol and ketamine-propofol combination for procedural sedation and analgesia in laparoscopic tubal ligation.

Background: Procedural sedation and analgesia is widely being used for female laparoscopic sterilization using combinations of different drugs at varying doses. This study compared the combination of fentanyl and propofol, and ketamine and propofol in patients undergoing outpatient laparoscopic tubal ligation, with respect to their hemodynamic effects, postoperative recovery characteristics, duration of hospital stay, adverse effects, and patient comfort and acceptability.

Settings And Design: Randomized, double blind.

Surrogacy: ethical and legal issues.

Surrogacy refers to a contract in which a woman carries a pregnancy "for" another couple. Number of infertile couples from all over the World approach India where commercial surrogacy is legal. Although this arrangement appears to be beneficial for all parties concerned,there are certain delicate issues which need to be addressed through carefully framed laws in order to protect the rights of the surrogate mother and the intended parents.

Effects of different doses of intraumbilical oxytocin on the third stage of labor.

Objective: To determine the optimal dose of oxytocin to be injected intraumbilically after fetal delivery for active management of the third stage of labor.

Methods: A prospective randomized study was carried out with 125 primigravidas to compare the duration of the third stage of labor following the intraumbilical administration of 50 mL of a normal saline solution alone (in a control group), or with 10 IU, 20 IU, or 30 IU of oxytocin. The volumes of blood lost were also compared.

Comparison of levonorgestrel and copper releasing intrauterine contraceptive device on body iron stores and menstrual bleeding patterns: experience on Indian women.

Introduction: The search for an ideal contraceptive device most suited for women of developing countries with anemia poses a challenge.

Aim: This study was conducted to compare the effects of levonorgestrel releasing (LNG) and copper releasing (Cu T) intrauterine contraceptive devices (IUCD) on body iron stores and menstrual bleeding patterns.

Methods: Hundred women desiring contraception were divided into two groups of fifty each where either LNG or Cu T 200 IUCD was inserted.

Preoperative predictors of mortality in adult patients with perforation peritonitis.

Introduction: There is paucity of data from India regarding the etiology, prognostic indicators, morbidity, and mortality patterns of perforation peritonitis. The objective of our study was to evaluate the predictors of mortality, preoperatively, for risk stratification of the patients and institution of an early goal-directed therapy.

Materials And Methods: Eighty-four consecutive patients presenting with perforation peritonitis, in the age group of 14-70 years scheduled for emergency laparotomy were studied prospectively.

Pregnancy outcome of women with gestational diabetes in a tertiary level hospital of north India.

Background: Women with gestational diabetes mellitus (GDM) pose an important public health problem because diabetes not only affects the maternal and fetal outcome, but these women and their fetuses are also at an increased risk of developing diabetes and related complications later in their life.

Objectives: The study was conducted to determine the maternal and fetal outcomes of 50 diabetic vs 50 normoglycemic pregnancies.

Materials And Methods: This was a retrospective analytical record-based study conducted in a tertiary level hospital.

A randomized clinical trial to compare the efficacy of different doses of intravaginal misoprostol with intracervical dinoprostone for cervical ripening and labor induction.

Objectives: To compare the efficacy of 25 vs. 50 microg of intravaginal misoprostol vs. intracervical dinoprostone for cervical ripening and labor induction.

N-Methyl-D-aspartate receptor modulators block hyperalgesia induced by acute low-dose morphine.

1. Following opioid-induced antinociception in mice, hyperalgesic responses may be observed. The present study was designed to evaluate the effect of different N-methyl-d-aspartate (NMDA) receptor modulators (magnesium, dextromethorphan, d-serine) on the development of morphine-induced hyperalgesia in mice.

Spinal anesthesia for lower segment Cesarean section in patients with stable eclampsia.

Study Objective: To report the use of spinal anesthesia in stable eclamptic patients.

Design: Prospective case series.

Setting: Emergency operating room of a metropolitan hospital.

Cytohistomorphologic features of malignant fibrous histiocytoma of the breast: a case report.

Background: Malignant mesenchymal tumors constitute < 1% of all malignant neoplasms of the breast. These include pure primary sarcoma of the breast, metastatic sarcoma and sarcomatous patterns in metaplastic carcinomas. On fine needle aspiration cytology (FNAC), the cellular features can suggest the diagnosis of sarcoma of the breast, although the potential exists for confusion with very poorly differentiated carcinoma.

Possible role of male factors in recurrent pregnancy loss.

To evaluate various causes possibly contributing towards recurrent pregnancy loss (RPL), particularly male factors. Prospective study of 75 couples with history of RPL who were investigated for genetic, anatomic, immunological, infective and systemic causes in both partners. Functional sperm capacity was assessed by the Hypo-osmotic swelling test (HOS), Acrosomal Reaction (AR), Nuclear condensation-decondensation test (NCD) and Seminal Total Leukocyte Count (TLC) along with semen analysis.

Teenage pregnancies and their obstetric outcomes.

This study was conducted to evaluate the obstetric performance of teenage women in India. In total, 13,210 women were included in the study, of whom 840 were teenagers (<19 years) and 12,370 were > or =20 years. Antepartum, intrapartum and postpartum events were recorded and comparative analysis was done.

Early oral hydration and its impact on bowel activity after elective caesarean section--our experience.

Aim: To assess the effects of early oral hydration after elective caesarian section.

Methods: Hundred women were selected from the maternity wards of LHMC and SSK Hospital, and alternately assigned into control and study groups of 50 each. Women with medical complications and antepartum haemorrhage were excluded.

A case of autoimmune myopathy in pregnancy.

Autoimmune diseases are not found frequently with pregnancy in clinical practice. Polymyositis Dermatomyositis have a prevalence of 2.4-10.

Prospective study of saline infusion sonohysterography in evaluation of perimenopausal and postmenopausal women with abnormal uterine bleeding.

Aim: To evaluate saline infusion sonohysterography as an investigative modality in abnormal uterine bleeding in perimenopausal and postmenopausal women.

Methods: Fifty-eight patients, 52 perimenopausal and six postmenopausal women, with abnormal uterine bleeding were selected from the department of Obstetrics and Gynecology of Shrimati Sucheta Kriplani Hospital. After complete work-ups, transvaginal examinations were performed followed by sonohysterographies.