3,769 results match your criteria: "Lacrimal Gland Tumors"
Six-year duration of upper respiratory tract signs in a cat secondary to a draining tract from an incomplete enucleation in the left orbit.
Can Vet J
December 2024
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, 1800 Christensen Drive, Ames, Iowa 50011, USA (Diaz); Internal Medicine Department, Ottawa Animal Emergency and Specialty Hospital, 1155 Lola Street #201, Ottawa, Ontario K1K 4C1 (Milaszewska); Antech Diagnostics, 2616 Bank Street, Ottawa, Ontario K1T 1M9 (Labelle).
This case report describes a 10-year-old spayed female domestic medium-hair cat with chronic upper respiratory signs related to a remnant of the left globe in the orbit after incomplete enucleation, causing a draining tract. A CT scan, complete blood (cell) count, biochemical analysis, rhinoscopy, biopsy, culture, histopathologic analysis, and surgical revision of enucleation were done. Complete blood (cell) count was unremarkable.
View Article and Find Full Text PDF[Efficacy of wound exclusion combined with silicone tube bicanalicular intubation in the treatment of pigmented nevi of the lacrimal punctum].
Zhonghua Yan Ke Za Zhi
December 2024
Department of Ophthalmology, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou310004, China.
Article Synopsis
- A total of 15 patients (5 men, 10 women) underwent the procedure, which involved excising the nevus while placing a silicone tube to support the area; surgeries lasted about 22 minutes on average.
- Post-surgery results showed no recurrence of nevi, healthy healing with normal eyelid appearance, and no significant complications observed during follow-up periods ranging from 6 months to 2 years.
Targeted RNA sequencing in diagnostically challenging head and neck carcinomas identifies novel MON2::STAT6, NFATC2::NUTM2B, POC5::RAF1, and NSD3::NCOA2 gene fusions.
Histopathology
December 2024
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Aims: Although molecular tests developed for a growing list of oncogenic alterations have significantly aided in the classification of head and neck carcinomas, tumours in which prototypical histologic and immunophenotypic features are lacking or only partially developed continue to pose diagnostic challenges. Searching for known diagnostic and therapeutic targets by clinical next-generation sequencing (NGS) assays can often lead to new discoveries.
Methods And Results: We present our institutional experience in applying targeted RNA NGS in 36 head and neck carcinomas that were morphologically difficult to classify between 2016 and 2023.
Role of vitamin A on the ocular surface.
Exp Eye Res
January 2025
Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Medical Group), Qingdao, Shandong, 266042, China. Electronic address:
Article Synopsis
[Diverse manifestations of orbital pseudotumor in a six-year-old child (case study)].
Vestn Oftalmol
November 2024
Kazan State Medical University, Kazan, Russia.
Article Synopsis
Adenoid Cystic Carcinoma of the Lacrimal Gland.
J Curr Ophthalmol
October 2024
Department of Ophthalmology, University of Balamand, Balamand, Lebanon.
Purpose: To explore the various aspects of adenoid cystic carcinoma of the lacrimal gland (LACC), including its clinical features, presentations, genetic factors, as well as current and potential future treatment options.
Methods: A thorough exploration of the literature was conducted by extensively searching the PubMed database. A total of 68 articles with a primary focus on adenoid cystic carcinoma were selected.
Presumed Choroidopathy of IgG4-Related Disease Discovered During 16-Year Follow-Up of a Patient With Polycystic Kidney Disease.
Cureus
October 2024
Nephrology, Okayama University Hospital, Okayama City, JPN.
Immunoglobulin G4 (IgG4)-related disease is characterized by infiltration with IgG4-producing plasma cells in different organs and the elevation of serum IgG4. We present a patient with polycystic kidney disease in long-term follow-up who developed bilateral lacrimal gland enlargement and presumed IgG4-related choroidopathy at different time points. A 45-year-old woman developed bilateral upper eyelid swelling.
View Article and Find Full Text PDFClinicopathological features of lacrimal gland biopsy lesions in 582 Chinese patients.
Sci Rep
November 2024
Department of Ophthalmology, West China Hospital of Sichuan University, No.37 Guoxue Xiang, Wuhou District, Chengdu, 610041, Sichuan Province, China.
Background This study was conducted to assess the clinicopathological characteristics of biopsy lesions in the lacrimal gland, in response to evolving pathological technologies and the emergence of new diseases. A retrospective review of case notes was conducted for 582 patients with biopsied lacrimal gland lesions at West China Hospital of Sichuan University in China. This study, spanning from January 1, 2010, to December 31, 2021, recorded demographics, clinical features, imaging findings, histopathological diagnoses, and recurrence rates.
View Article and Find Full Text PDFPersonalized Immunotherapy Achieves Complete Response in Metastatic Adenoid Cystic Carcinoma Despite Lack of Conventional Biomarkers.
Curr Oncol
September 2024
Medicana Health Group, Precision Oncology Center, 34750 Istanbul, Türkiye.
Article Synopsis
- * Genomic profiling of ACC shows low tumor mutational burden, a lack of actionable targets, and negative PD-L1, leading to recommendations for a specific combination of anti-PD-1 and anti-CTLA-4 immunotherapy.
- * A successful complete response was noted in a patient with treatment-resistant locally recurrent lacrimal gland ACC through personalized immunotherapy combined with other therapeutic strategies, highlighting the importance of considering patient-specific factors in immune-cold cancers.
Non-invasive miRNAs for early detection and diagnosis of lacrimal adenoid cystic carcinoma.
Discov Oncol
October 2024
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No.639 Zhizaoju Road, Shanghai, 200025, People's Republic of China.
Lacrimal adenoid cystic carcinoma (LACC) is one of the most common malignant epithelial tumors of the lacrimal gland, characterized by high rates of local recurrence, distant metastases, and tumor-related mortality. This malignancy impairs the lacrimal gland's ability to secret tears, thereby disrupting the normal function of the ocular surface. Due to ineffective diagnostic approaches and the complex anatomical location of the lacrimal gland within the orbit, many LACC patients are often diagnosed at the later stages.
View Article and Find Full Text PDFOptimizing surgical approaches for lacrimal gland adenoid cystic carcinoma to minimize cross-organ invasion.
Int J Ophthalmol
October 2024
Department of Ocular Oncology, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China.
Aim: To evaluate the outcomes of eye-sparing surgery for lacrimal gland adenoid cystic carcinoma and the impact on tumor recurrence and orbital integrity.
Methods: The study enrolled four patients with recurrent lacrimal gland adenoid cystic carcinoma. The outcome focused on the relevance of the integrity of the lateral orbital wall to the occurrence of extraorbital metastasis in the local recurrence of lacrimal gland adenoid cystic carcinoma.
Efficacy of Surgical Reconstruction With Rectus Abdominis Flap Following en Bloc Resection of the Orbital Contents for Malignant Lacrimal Gland Cancer: A Case Series.
Cureus
September 2024
Department of Plastic Surgery, Kobe University Graduate School of Medicine, Kobe, JPN.
Article Synopsis
- Surgical excision of advanced lacrimal gland carcinoma often requires removing the orbital contents and reconstructing the anterior skull base with tissue that can withstand radiotherapy; this process involves complex considerations regarding patient quality of life and aesthetics.
- In three cases, a rectus abdominis flap was utilized for reconstruction after en bloc resection, chosen for its reliable structure and blood flow to fill the surgical cavity.
- The flap successfully survived with no complications, but showed notable shrinkage after six months, leading to the recommendation for using a slightly larger flap volume initially to account for future reductions.
Article Synopsis
- Immunoglobulin-G4 (IgG4)-related disease is a rare fibro-inflammatory condition that can impact multiple organs simultaneously or at different times, often presenting with tumor-like organ growth.
- Key affected organs include the lacrimal glands, salivary glands, pancreas, and more, with distinctive histopathological features like dense IgG4-positive plasma cells and storiform fibrosis.
- The disease has an estimated incidence of less than 1 in 100,000 people globally, and a specific case of IgG4-related vasculitis was diagnosed through lung fine needle aspiration biopsy, highlighting its rarity in medical literature.
Magnetic resonance diffusion-weighted imaging in lacrimal gland lymphoma versus inflammation: A comparative study.
Indian J Ophthalmol
October 2024
School of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Article Synopsis
- - The study aimed to assess how diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) can differentiate between inflammation and malignant lymphoma of the lacrimal gland.
- - Researchers analyzed 28 patients over a 10-year period, finding that 61% had inflammation (dacryoadenitis) while 21% had lymphoma, with ADC values being significantly lower for lymphoma cases compared to inflammation.
- - The results indicate that DWI can be a valuable imaging tool to help distinguish between these two conditions in the lacrimal gland.
Article Synopsis
- * The study presents a case of a 42-year-old woman with HER-2 positive primary ductal adenocarcinoma, detailing her treatment journey, which included surgery, radiotherapy, chemotherapy, and targeted therapy, leading to a favorable outcome.
- * The report highlights the importance of early diagnosis and a multimodal treatment approach for such aggressive tumors, emphasizing the need for documenting individual cases to improve patient management.
Unveiling a distinctive presentation: Benign manifestation of primary ductal adenocarcinoma of the lacrimal gland.
J Fr Ophtalmol
November 2024
Department of Ophthalmology, Fujian Medical University Union Hospital, Fuzhou, Fujian, 350001, China. Electronic address:
Article Synopsis
- The case involves a man diagnosed with primary ductal adenocarcinoma of the right lacrimal gland, initially presenting as a well-defined cystic lesion.
- The patient underwent total resection of the mass, which showed distinct histopathological features and marked tumor heterogeneity, along with successful local treatment with radiotherapy.
- Primary ductal adenocarcinoma of the lacrimal gland is rare, and its presentation can vary, with treatment methods tailored to specific tumor characteristics.
Orbital Lesions: A bird's eye view of series of 2068 cases in 27 years in a tertiary care hospital in Pakistan.
Pak J Med Sci
September 2024
Imran Ahmad, MBBS, DOMS, MPH. Principal Medical Officer, Institute of Ophthalmology, King Edward Medical University, Mayo Hospital Lahore, Pakistan.
Objective: To determine the relative frequency of orbital lesions based on the site of origin and histopathology at a Tertiary care hospital (Mayo Hospital, Lahore Pakistan) from 1996 till 2022 (27 years).
Methods: This descriptive case series included 2651 patients of all age groups presenting with orbital lesions who initially got enrolled at Institute of Ophthalmology Mayo Hospital, Lahore from 1996 till 2022. Of these, 583 patients left against medical advice.
[Polymorphic lymphoproliferative disorder, lymphomatoid granulomatosis-type, in a patient with iatrogenic immunosuppression, an unusual entity].
Rev Med Chil
November 2023
Sección Hematología, Unidad de Hematología Clínica, Hospital del Salvador, Chile.
Article Synopsis
- Patients with immunodeficiency are at a higher risk of developing certain cancers, particularly mature lymphoid neoplasms and lymphoproliferative disorders.
- A 50-year-old woman on immunosuppressive therapy for dermatomyositis presented with swollen lacrimal glands, weight loss, and night sweats, leading to an elective biopsy.
- Post-surgery, she experienced acute abdominal issues that revealed multiple organ lesions and ultimately led to a diagnosis of polymorphic B-lymphoproliferative disorder resembling lymphomatoid granulomatosis, a rare condition linked to immunosuppression.
Prognostic Impact of Notch1 Intracellular Domain, P63, and c-MYC in Lacrimal Gland Adenoid Cystic Carcinoma.
Invest Ophthalmol Vis Sci
September 2024
Orbital Oncology & Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States.
Purpose: We assessed whether NICD1 expression, c-MYC expression, and P63 expression by immunohistochemistry (IHC) correlate with prognosis and high-risk clinicopathological features in lacrimal gland adenoid cystic carcinoma (ACC).
Methods: Records of patients with lacrimal gland ACC who underwent surgery between 1998 to 2018 were reviewed. Clinicopathologic and treatment data were collected.
23-year review of spheno-orbital meningioma: clinical, radiological, and pathological insights from 100 cases.
BMC Ophthalmol
September 2024
Senior Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, Beijing, 100080, China.
Background: Spheno-orbital meningioma (SOM) represents a unique variant of sphenoid wing meningiomas, distinguished by its propensity for bone infiltration and cranio-orbital involvement. SOM exhibits a considerable incidence of misdiagnosis and recurrence.
Purposes: To elucidate the clinical, radiological, and pathological characteristics of SOM.
Population-Based Incidence and Clinical Characteristics of Ocular Adnexal Tumors in Olmsted County, Minnesota.
Ophthalmic Epidemiol
August 2024
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.
Article Synopsis
- The study analyzed the occurrence and features of ocular adnexal tumors in Olmsted County, Minnesota, over a decade from 2006 to 2015.
- During this period, 717 patients were diagnosed with ocular adnexal tumors, predominantly benign eyelid lesions, with an incidence rate of 59.7 per 100,000 individuals per year.
- The findings highlighted that while most tumors were benign, a significant number of malignant cases were also identified, particularly basal and squamous cell carcinomas, underscoring the need for awareness in clinical practice for diagnosis and referrals.
Molecular Analysis of Salivary and Lacrimal Adenoid Cystic Carcinoma.
Cancers (Basel)
August 2024
National Ophthalmic Pathology Laboratory, D04 T6F6 Dublin, Ireland.
Adenoid cystic carcinoma (ACC) of head and neck origin is associated with slow but relentless progression and systemic metastasis, resulting in poor long-term survival rates. ACC does not respond to conventional chemotherapy. Determination of molecular drivers may provide a rational basis for personalized therapy.
View Article and Find Full Text PDFCanalicular Cyst After Punctal Plug Insertion.
J Craniofac Surg
October 2024
Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine.
Article Synopsis
- - A 73-year-old male developed a canalicular cyst on his right lower eyelid after having absorbable punctal plugs inserted for dry eye syndrome 8 years earlier.
- - The cyst was found on the medial side of the eyelid, causing ectropion but showing no signs of inflammation; surgical incision and drainage reduced its size.
- - Imaging studies indicated cystic dilation and obstruction in the canaliculus, highlighting that canalicular cysts should be considered when similar patients present with masses in the eye area.
Surgical Challenges in the Management of Respiratory Epithelial Cyst Involving the Lacrimal Sac.
Ophthalmic Plast Reconstr Surg
November 2024
Respiratory epithelial cysts are uncommon lesions that can be congenital or acquired cystic malformations. Beyond the respiratory system, the location of the respiratory epithelial cyst has been described in the central nervous system, orbits, and the maxillofacial region. The common etiology is believed to be sequestration or entrapment of the epithelial cells of the paranasal sinus.
View Article and Find Full Text PDFPrognostic factors for lacrimal gland adenoid cystic carcinoma: a retrospective study in Chinese patients.
Int J Ophthalmol
August 2024
Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Aim: To explore the prognostic factors for lacrimal gland adenoid cystic carcinoma (LGACC) in Chinese patients.
Methods: Clinical and histopathological data were reviewed in patients with pathologically confirmed LGACC. Local recurrence, metastasis, and disease-specific death were the main outcome measures.