1 results match your criteria: "Laboratory of Immunopharmacology and Shanghai Institute of Materia Medica[Affiliation]"
WSS45, a sulfated alpha-D-glucan, strongly interferes with Dengue 2 virus infection in vitro.
Acta Pharmacol Sin
May 2010
Laboratory of Immunopharmacology and Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Aim: To investigate the mode of action of WSS45, one sulfated derivative of an alpha-D-glucan from the Gastrodia elata Bl, on the multiplication cycle of dengue virus serotype 2 (DV2), including initial infection and intracellular replication.
Methods: Virus multiplication in BHK cells were monitored by qRT-PCR, plaque reduction assay, and flow cytometry. Initial virus infection was dissected into adsorption and penetration steps by converting temperature and treating by acid glycine.