1 results match your criteria: "Laboratory for Cognitive Neurology Leuven Brain Institute[Affiliation]"
Lack of association between bridging integrator 1 () rs744373 polymorphism and tau-PET load in cognitively intact older adults.
Alzheimers Dement (N Y)
February 2022
Department of Neurosciences, Laboratory for Cognitive Neurology Leuven Brain Institute, KU Leuven Leuven Belgium.
Article Synopsis
- The rs744373 risk polymorphism is associated with increased [F]AV1451 signal in non-demented older adults, but its relationship with tau, amyloid beta, and cognitive impairment in early Alzheimer's stages is unclear.
- A study involving 59 cognitively normal participants and 52 mild cognitive impairment patients did not find a significant effect of the rs744373 variant on [F]AV1451 binding, although some differences were noted in the MCI group.
- The findings suggest that the previously reported link between the rs744373 risk allele and elevated [F]AV1451 signal may be influenced by group characteristics, highlighting the need for careful consideration in research on Alzheimer's disease.*