624 results match your criteria: "La Rabta Hospital.[Affiliation]"

This case report describes a rare instance of intraperitoneal rupture in a redegenerated uterine fibroid during pregnancy. A 38-year-old woman at 38 weeks gestation, with a history of a single pregnancy, presented with mild pelvic pain persisting through late pregnancy. An emergency caesarean section was performed due to acute fetal distress during labor.

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Olive mill wastewater (OMWW), a byproduct of olive oil extraction, constitutes a natural resource of phenolic compounds. Hydroxytyrosol (HT), the predominant compound, exhibits antioxidant, anti-inflammatory, and neuroprotective effects. This research aims to evaluate the effect of OMWW bioproduct rich in HT on retinal glial function, glutamate metabolism and synaptic transmission alterations mediated by hyperglycemia and dyslipidemia in high-calorie diet (HCD) induced diabetic retinopathy (DR) in Psammomys obesus.

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Retroperitoneal leiomyosarcoma diagnosis and management in a chronic kidney disease context: A case report.

Int J Surg Case Rep

January 2025

Department of Surgery A La Rabta Hospital, Tunis, Tunisia; Faculty of medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.

Introduction And Importance: While the treatment approach for sarcomas seems straightforward and well-defined, we often encounter several diagnostic or therapeutic challenges in clinical practice. This article presents a case of retroperitoneal leiomyosarcoma in a patient with chronic kidney disease, highlighting the complexity of managing such cases.

Case Report: A 63-year-old woman with a history of chronic kidney disease presented with a progressively enlarging mass in her right flank.

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Objectives: Evaluate diabetic patients' knowledge, practices, and the prevalence of complications during Ramadan fasting (RF) before and after an education program.

Methods: We conducted a prospective study including 140 consecutive diabetic patients (DP) who intended to observe RF in 2023. Patients underwent a questionnaire and received pre-Ramadan education (PRE) according to the IDF-DAR 2021 recommendations.

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Magnetic resonance imaging (MRI) is used for diagnosing placenta accreta spectrum disorders (PASDs) because of its advanced soft-tissue contrast and spatial resolution capabilities, offering better contrast, improved spatial resolution, and a wider field of view compared with ultrasound. Using a 1.5-Tesla MRI protocol with multiple sequences, MRI can detect indicative signs of PASD such as placental signal heterogeneity, interruption of the myometrium-placenta interface, and abnormal vascularization.

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Introduction And Importance: Ipsilateral proximal and distal radius fractures without elbow dislocation are extremely rare injuries and a few cases have been reported. Currently, there is no well-established consensus regarding their optimal management.

Case Presentation: We report the case of a 57-year-old woman who had a right bipolar radius fracture after falling from a standing height.

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Fœtal sacrococcygeal teratoma type I: A case report.

Radiol Case Rep

February 2025

Pediatric Surgery Department, Tunis Faculty of Medicine El Manar University, Béchir Hamza Children's Hospital, Tunis, Tunisia.

Sacrococcygeal teratoma (SCT) is a rare congenital tumor typically diagnosed in neonates, with management challenges arising from the size of the tumor and associated delivery complications. In this case, a 32-year-old gravida 5 para 5 woman with a history of three prior cesarean sections was diagnosed with a giant type I SCT at 30 weeks of gestation through prenatal ultrasound, confirmed by fetal MRI. At 34 weeks, an emergency cesarean section was performed due to acute fetal distress, resulting in a newborn with transient respiratory distress.

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Pre-sacral glomangioma: a rare localization of glomus tumors: case report.

Ann Med Surg (Lond)

December 2024

General Surgery Department "B", La Rabta Hospital, The Faculty of Medicine, The University of Tunis El Manar, Tunis, Tunisia.

Introduction And Importance: Deep-located glomangiomas are rarely reported. Because of their scarcity, treatment strategy is hard to establish. Herein, the authors report the first case to our knowledge of pre-sacral glomangioma.

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Article Synopsis
  • Lichen Planus is an inflammatory skin condition linked to diseases like Inflammatory Bowel Disease and medication use, particularly sulfasalazine.* -
  • A 62-year-old patient with ulcerative colitis developed worsening rashes after three years on sulfasalazine, which were later confirmed as lichen planus through a tissue examination.* -
  • Discontinuing sulfasalazine led to some improvement in the skin lesions, emphasizing the need for careful patient assessments regarding medication and disease symptoms.*
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Gangliocytic paragangliomas are benign neuro-endocrine tumors of the ampulla of Vater. Their preoperative diagnosis is hampered by the low yield of biopsies and non-specific imaging. Their management relies then on resection.

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Plasma levels and diagnostic utility of VEGF, MMP-9 and TIMP-2 in the diagnosis of psoriasis forms.

Growth Factors

October 2024

Laboratory of Biochemistry, La Rabta Hospital Tunis and LR99ES11, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.

Article Synopsis
  • Psoriasis is a common autoimmune skin disease, but its exact cause is still unclear; this study explores whether specific biomarkers can indicate the presence and severity of the condition.
  • The research focuses on the relationship between serum levels of VEGF, MMP-9, and TIMP-2 in 115 psoriatic patients compared to 51 controls, using ELISA methods for measurement.
  • Findings show that while VEGF has low effectiveness in distinguishing between psoriasis variants, the combination of TIMP-2 and inflammation Z-score significantly improves discriminative power, highlighting the role of inflammation and tissue damage in the disease's progression.
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Anorectal melanoma: A case report of an unusual localization.

Int J Surg Case Rep

December 2024

Department of Surgery A La Rabta Hospital, Tunis, Tunisia; Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.

Introduction And Importance: Primary anorectal melanoma (ARM) is a rare neoplasm with an extremely poor prognosis. It represents less than 1 % of all melanomas and accounts for less than 1 % of anorectal malignancies. We report a case of anorectal primary melanoma treated surgically.

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Article Synopsis
  • Penile fractures, caused by trauma to the erect penis, require quick surgical treatment to prevent long-term issues like erectile dysfunction.
  • A study on 87 patients revealed that 51% experienced erectile dysfunction post-surgery, with factors like smoking, surgical method, and delay in treatment increasing risks.
  • The study highlights the need for immediate care after a penile fracture and stresses the importance of sexual education to reduce such injuries, particularly among younger individuals.
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Hook-shaped distal common bile duct due to peptic ulcer mimicking cholangiocarcinoma.

Int J Surg Case Rep

December 2024

Department of Surgery A La Rabta Hospital, Tunis, Tunisia; Faculty of Medicine of Tunis, Tunis El Manar University, Tunis, Tunisia.

Introduction And Importance: Internal and spontaneous bilio-digestive fistulas, without primary biliary disease, are an infrequent complication of the upper digestive tract. We report a case of a Hook-shaped distal common bile duct due to peptic ulcer mimicking cholangiocarcinoma.

Case Report: A 63-year-old patient, with no medical history, presented to the emergency department with recent jaundice.

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Background: Synchronous abscesses of the prostate and seminal vesicles represent a rare but clinically significant form of purulent retention. They pose diagnostic and therapeutic challenges and are associated with considerable morbidity and a high risk of sepsis.

Case Presentation: We present the case of a 60-year-old Caucasian man with a history of insulin-dependent diabetes mellitus, who had a voluminous prostatic abscess associated with a right seminal vesicle abscess due to compression of the right ejaculatory duct, and who presented to our department with sepsis.

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Introduction: This study aims to investigate the efficacy and tolerance of biologic disease-modifying anti-rheumatic drug (bDMARDs) in the current management of rheumatoid arthritis (RA) by identifying the retention time and survival rate of bDMARDs.

Materials And Methods: We conducted a retrospective cohort study including Tunisian patients initiating bDMARD treatment between 2016 and 2018 whose data were collected from the National Health Insurance Fund (NHIF). The NHIF is the national office which organises and centralises patients under bDMARDs from all over the country.

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Introduction: Children undergoing long-term hemodialysis (HD) face a reduction in life expectancy mostly due to cardiovascular mortality. Effects of HD on cardiac function have not been fully elucidated in pediatric population.

Aim: This study aimed to assess HD session impact on cardiac function in pediatric patients using conventional and strain echocardiography.

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Mucopolysaccharidosis type I: founder effect of the p.P533R mutation in North Africa.

BMC Genomics

October 2024

Research Laboratory of Human Genome and Multifactorial Diseases (LR12ES07), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.

Background: Mucopolysaccharidosis type I is a lysosomal storage disease resulting from a deficiency in alpha-L-iduronidase (IDUA), which causes the accumulation of partially degraded dermatan sulfate and heparan sulfate. This retrospective study, spanning eight years, analyzed data from 45 MPSI patients. The report aimed to explore the potential origin of the p.

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Article Synopsis
  • Many faculties worldwide are implementing mentoring programs to enhance student learning, skills, belonging, and well-being.
  • This review aims to discuss the principles and recommendations of effective mentoring projects in academic settings.
  • It also presents the Faculty of Medicine of Tunis's perspective on adopting this mentoring approach.
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Objective: To scrutinize the progression of clinical reasoning and theoretical knowledge by comparing the impact of Clinical Reasoning-Based Learning (CRBL) sessions with interactive lectures (IL).

Methods: In this experimental study conducted from November 15, 2021, to May 7, 2022, we focused on second-year students in the second cycle of medical studies. Four specific urologic emergency scenarios (nephritic colic, macroscopic hematuria, acute scrotal pain, and urinary incontinence in men) were selected for interactive teaching sessions.

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Adenocarcinoma of the prostate affects up to 70 % of men over 80 and is the second leading cause of cancer related death in men. We reported an unusual case of a giant prostatic adenocarcinoma compressing bilaterally the 2 external and internal iliac veins that was revealed by a bilateral edema of the lower limbs after histological confirmation the patient was treated by radiotherapy and hormone therapy with a clinical amelioration.

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Article Synopsis
  • Spinal cavernomas represent about 5% of spinal vascular malformations, with intradural cases making up only 3% and often occurring intramedullary.
  • A 58-year-old woman experienced progressive neuralgia and extremity paresthesia; MRI indicated a C2-C4 lesion causing spinal cord compression.
  • After a midline laminectomy for tumor removal, the lesion was identified as a cavernoma, and follow-up MRI confirmed complete resection four months later.
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Objective: Tuberculosis remains a major global health challenge, with delayed diagnosis contributing to increased transmission and disease burden. While microbiological tests are the gold standard for confirming active tuberculosis, many cases lack microbiological evidence, necessitating additional clinical and laboratory data for diagnosis. The complete blood count (CBC), an inexpensive and widely available test, could provide a valuable tool for tuberculosis diagnosis by analyzing disturbances in blood parameters.

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Article Synopsis
  • The increasing rates of obstetric complications, like post-partum hemorrhage from placenta accreta spectrum, necessitate new treatment methods, highlighting the effectiveness of internal iliac artery embolization for managing obstetric bleeding.
  • Two case studies demonstrate successful outcomes: a 38-year-old patient experienced persistent bleeding after a subtotal hysterectomy and was saved by arterial embolization, while a 35-year-old patient with placenta accreta after a hysterectomy also benefited from the procedure.
  • The discussion emphasizes the importance of interventional radiology in treating postpartum hemorrhage and suggests that consulting a specialized radiologist can be crucial for improving patient outcomes post-surgery.
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Article Synopsis
  • Endocarditis related to medical care can be particularly dangerous for hemodialysis patients due to their weakened immune systems and various types of vascular access.
  • A 38-year-old hemodialysis patient presented with fever and neurological symptoms, ultimately diagnosed with infective mitro-aortic endocarditis and associated complications like subarachnoid hemorrhage.
  • Despite initial treatment showing promise, the patient's condition deteriorated, leading to fatal septic shock and multiple organ failure, highlighting the risks faced by this vulnerable population.
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