Magnetic Resonance Imaging Findings of Placenta Accreta Spectrum Disorder: A Pictorial Review.

Magnetic resonance imaging (MRI) is used for diagnosing placenta accreta spectrum disorders (PASDs) because of its advanced soft-tissue contrast and spatial resolution capabilities, offering better contrast, improved spatial resolution, and a wider field of view compared with ultrasound. Using a 1.5-Tesla MRI protocol with multiple sequences, MRI can detect indicative signs of PASD such as placental signal heterogeneity, interruption of the myometrium-placenta interface, and abnormal vascularization.

Fœtal sacrococcygeal teratoma type I: A case report.

Sacrococcygeal teratoma (SCT) is a rare congenital tumor typically diagnosed in neonates, with management challenges arising from the size of the tumor and associated delivery complications. In this case, a 32-year-old gravida 5 para 5 woman with a history of three prior cesarean sections was diagnosed with a giant type I SCT at 30 weeks of gestation through prenatal ultrasound, confirmed by fetal MRI. At 34 weeks, an emergency cesarean section was performed due to acute fetal distress, resulting in a newborn with transient respiratory distress.

Giant prostatic adenocarcinoma revealed by bilateral edema of the lower limbs.

Adenocarcinoma of the prostate affects up to 70 % of men over 80 and is the second leading cause of cancer related death in men. We reported an unusual case of a giant prostatic adenocarcinoma compressing bilaterally the 2 external and internal iliac veins that was revealed by a bilateral edema of the lower limbs after histological confirmation the patient was treated by radiotherapy and hormone therapy with a clinical amelioration.

Fibrous pseudo tumor of the tunica vaginalis mimicking paratesticular cancer.

Fibrous pseudo tumor of the tunica vaginalis is a rare lesion affecting men representing a challenge in its diagnosis and treatment. We reported the case of a 17 year old male patient who presented for a right scrotal mass. Surgical resection of the mass was performed and the histological diagnosis was a fibrous pseudo tumor of the tunica vaginalis.

Isolated hydatic cyst of seminal vesicle: A new case.

We present a rare case of a hydatid cyst involving the seminal vesicle of a 39-year-old man. Left lumbar pain was the initial symptom. CT-scan and MRI revealed a retro vesical cystic mass arising from the seminal vesicle.

Dilated Cardiomyopathy due to the Novel Missense Mutation m.14757T>C.

Mitochondrial DNA (mtDNA) mutations frequently manifest with multisystem disease, including cardiomyopathy (CM). Various studies described mutations in protein-encoding mtDNA genes, such as cytochrome-b, manifesting with CM. A detailed clinical, biochemical, and molecular genetic analysis was performed in a 40-year-old male with dilated CM (DCM) to detect the underlying mtDNA defect.

Enterosalpingeal fistula complicating Crohn's disease: Report of two cases and review of the literature.

Introduction And Importance: Reports of enterosalpingeal fistulae complicating Crohn's disease are scarce. They involve the last ileal loop and lead to a progressive destruction of the salpinx. Usually, no genital symptoms are found.

Immune-enrichment of non-small cell lung cancer baseline biopsies for multiplex profiling define prognostic immune checkpoint combinations for patient stratification.

Background: Permanence of front-line management of lung cancer by immunotherapies requires predictive companion diagnostics identifying immune-checkpoints at baseline, challenged by the size and heterogeneity of biopsy specimens.

Methods: An innovative, tumor heterogeneity reducing, immune-enriched tissue microarray was constructed from baseline biopsies, and multiplex immunofluorescence was used to profile 25 immune-checkpoints and immune-antigens.

Results: Multiple immune-checkpoints were ranked, correlated with antigen presenting and cytotoxic effector lymphocyte activity, and were reduced with advancing disease.

CARD14 alterations in Tunisian patients with psoriasis and further characterization in European cohorts.

Background: Rare highly penetrant gain-of-function mutations in caspase recruitment domain family, member 14 (CARD14) can lead to psoriasis, a chronic inflammatory disease of the skin and other organs.

Objectives: To investigate the contribution of rare CARD14 variants to psoriasis in the Tunisian population and to expand knowledge of CARD14 variants in the European population.

Methods: CARD14 coding exons were resequenced in patients with psoriasis and controls from Tunisia and Europe, including 16 European cases with generalized pustular psoriasis (GPP).

Ureteral spread of a primary cutaneous diffuse large B-cell lymphoma, leg type.

We report a case of 76-year-old man, with a past medical history of primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), who presented with ureteral tumor diagnosed as urothelial carcinoma on imaging investigations. Histological examination showed an unusual finding. The tumor was a ureteral localization of the PCDLBCL-LT previously diagnosed.